Angiotensin-converting Enzyme Inhibition Improves the Effectiveness of Transcutaneous Carbon Dioxide Treatment

Abstract

The short- and long-term decrease of ADMA levels suggests that CO is not only a vasodilator, but also has a beneficial effect on the NO pathway. ACE inhibition seems to enhance the effect of CO treatment.

Transcutaneous Carbon Dioxide Treatment Affects Heart Rate Variability – A Pilot Study

“…Consequently, an increase in both sympathetic and parasympathetic activity can occur during CO 2 treatment, resulting in unchanged heart rate, systolic and diastolic blood pressure. In line with our previous finding, the changes in overall HRV suggest that CO 2 is not simply a vasodilator but is capable of altering the function of the cardiovascular system, possibly by activating endogenous mechanisms leading to vasodilatation (18). Bickel et al found increased sympathetic activity during positive pressure CO 2 pneumoperitoneum by HRV analysis possibly due to hypercarbia and tension of the peritoneum; however, in the present study there was no peritoneal tension (19).…”

Transcutaneous Carbon Dioxide Treatment Is Capable of Reducing Peripheral Vascular Resistance in Hypertensive Patients

“…The results of our previous study partly confirmed this hypothesis. Our study showed that CO 2 treatment has beneficial effects on the NO pathway (7). NO-related vasodilatation may be an explanation for the delayed response of AIXao.…”

“…Informed written consent was obtained from every patient. This patient selection protocol was used in a previous study investigating the effects of CO 2 treatment on the nitric oxide system (7).…”

“…However, Veselá and Wilhelm found CO 2 to play a protective role in scavenging free radicals and suppressing oxidative metabolism (6). A recent study demonstrated that CO 2 treatment is capable of reducing the level of asymmetric dimethylarginine, which is a marker of oxidative stress (7). Another study suggested that the transcutaneous application of CO 2 could have therapeutic effects on muscle atrophy (8).…”

Facial application of high-concentration carbon dioxide prevents epidermal impairment associated with environmental changes

“…This study was prompted by the fact that naturally occurring CO 2 springs have long been used to improve health conditions and have a wide variety of applications. CO 2 bathing and transdermal administration of CO 2 are reported to be effective in improving circulatory and immunological disorders, such as hypertension, artery occlusion, intermittent claudication, and Raynaud’s syndrome 8–15. CO 2 -induced changes in hemodynamics, microcirculation, vasomotion, and thermoregulation in human skin (healthy or disordered) have been confirmed using near-infrared spectroscopy, magnetic resonance imaging, blood flow meters, and thermography.…”