Angiotensin converting enzyme‐inhibitory activity and antimicrobial effect of fermented camel milk (<i>Camelus dromedarius</i>)

Alhaj, Omar A.; Metwalli, Ali; Ismail, Elsayed A.; Ali, Hatem S.; Al‐Khalifa, Abdulrahman S.; Kanekanian, Ara

doi:10.1111/1471-0307.12383

Cited by 36 publications

(16 citation statements)

References 35 publications

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“…rhamnosus. The ACE inhibitions of camel milk fermented by Lc.K782 were greater than those reported by Alhaj et al (2017), who fermented camel milk by Lb. acidophilus and Streptococcus thermophiles or Lactobacillus helveticus.…”

Section: Ace-inhibition Activitycontrasting

confidence: 64%

“…Australia has half a million wild camels, especially in the Northern Territory. Worldwide, there are 2 wellknown species of camels: 1-humped Arabian camels or dromedaries (Camelus dromedarius; the camels of the plains) and 2-humped Bactrian camels (Camelus bac-901 2013; Alhaj et al, 2017). Few attempts have been made to compare the health-promoting benefits of fermented camel milk with the benefits of other fermented mammalian milks, particularly fermented bovine milk (Mymensingh, 2007;Moslehishad et al, 2013;Shori, 2013), with an emphasis on ACE inhibition, antioxidant, and proteolytic activities.…”

Section: Introductionmentioning

confidence: 99%

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In vitro investigation of anticancer, antihypertensive, antidiabetic, and antioxidant activities of camel milk fermented with camel milk probiotic: A comparative study with fermented bovine milk

Ayyash

Dhaheri

Mahadin

et al. 2018

Journal of Dairy Science

130

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This study aimed to investigate in vitro anticancer activity by antiproliferative activity, antihypertensive activity by angiotensin-converting enzyme inhibition, antidiabetic activity by α-amylase and α-glucosidase inhibitions, and antioxidant activities of camel milk fermented with camel milk probiotic compared with fermented bovine milk. The camel milk probiotic strain Lactococcus lactis KX881782 (Lc.K782) and control Lactobacillus acidophilus DSM9126 (La.DSM) were used to prepare fermented camel and bovine milks separately. The proteolytic activities of water-soluble extract (WSE) in all fermented camel milk were higher than those in fermented bovine milk. The α-glucosidase inhibitions in both milk types fermented by Lc.K782 ranged from 30 to 40%. Camel milk fermented by Lc.K782 had the highest antioxidant activity by 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulphonic acid). The highest angiotensin-converting enzyme inhibition of WSE in camel milk fermented by Lc.K782 was >80%. The proliferations of Caco-2, MCF-7, and HELA cells were more inhibited when treated with WSE of fermented camel milk extracts.

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Section: Ace-inhibition Activitycontrasting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

In vitro investigation of anticancer, antihypertensive, antidiabetic, and antioxidant activities of camel milk fermented with camel milk probiotic: A comparative study with fermented bovine milk

Ayyash

Dhaheri

Mahadin

et al. 2018

Journal of Dairy Science

130

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“…Unhydrolyzed CWP showed ACE-IA, which could be due to the presence of some bioactive peptides liberated by the bacterial contamination of the raw camel milk or by the endogenous proteolytic enzymes [ 22 ]. Similarly, Alhaj et al [ 23 ] and Jafar et al [ 24 ] reported ACE-IA for the untreated camel milk and the unhydrolyzed CWP. The hydrolysis of the CWP with papain significantly ( p ˂ 0.05) enhanced its ACE-IA as a result of the augmented release of multiple bioactive peptides with ACE-IA.…”

Section: Resultsmentioning

confidence: 87%

Angiotensin-I Converting Enzyme Inhibition and Antioxidant Activity of Papain-Hydrolyzed Camel Whey Protein and Its Hepato-Renal Protective Effects in Thioacetamide-Induced Toxicity

Osman

El-Hadary

Korish

et al. 2021

Foods

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Papain hydrolysis of camel whey protein (CWP) produced CWP hydrolysate (CWPH). Fractionation of CWPH by the size exclusion chromatography (SEC) generated fractions (i.e., SEC-F1 and SEC-F2). The angiotensin- converting- enzyme inhibitory activity (ACE-IA) and free radical scavenging actions were assessed for CWP, CWPH, SEC-F1, and SEC-F2. The SEC-F2 exerted the highest ACE-IA and scavenging activities, followed by CWPH. The protective effects of CWPH on thioacetamide (TAA)-induced toxicity were investigated in rats. The liver enzymes, protein profile, lipid profile, antioxidant enzyme activities, renal functions, and liver histopathological changes were assessed. Animals with TAA toxicity showed impaired hepatorenal functions, hyperlipidemia, and decreased antioxidant capacity. Treatment by CWPH counteracted the TAA-induced oxidative tissue damage as well as preserved the renal and liver functions, the antioxidative enzyme activities, and the lipid profile, compared to the untreated animals. The current findings demonstrate that the ACE-IA and antioxidative effects of CWPH and its SEC-F2 fraction are worth noting. In addition, the CWPH antioxidative properties counteracted the toxic hepatorenal dysfunctions. It is concluded that the hydrolysis of CWP generates a wide range of bioactive peptides with potent antihypertensive, antioxidant, and hepatorenal protective properties. This opens up new prospects for the therapeutic utilization of CWPH and its fractions in the treatment of oxidative stress-associated health problems, e.g., hypertension and hepatorenal failure.

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“…Bioactive peptides derived from Lactobacillus acidophilus and Streptococcus thermophilus fermented camel milk showed ACE inhibitory and antimicrobial activities against Bacillus cereus, Salmonella Typhimurium, and Staphylococcus aureus. Bioactivities were time and strain-dependent wherein microbial inhibition activity was observed after 12 h of incubation till 15 days (Alhaj et al 2018). Camel milk fermented by Leuconostoc lactis, isolated from traditional fermented camel milk (Chal),had antioxidant activity as revealed by significantly higher ABTS and DPPH activity (Soleymanzadeh et al 2016).…”

Section: Fermented Milk (Yoghurt)mentioning

confidence: 99%

A comprehensive review on bioactive peptides derived from milk and milk products of minor dairy species

Guha

Sharma

Deshwal

et al. 2021

Food Prod Process and Nutr

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Milk from different species has been exploited for the isolation of various functional ingredients for decades. Irrespective of the source, milk is considered as a complete food, as it provides essential nutrients required by the human body. Proteins and their fractions are valuable sources of bioactive peptides that might exert a health beneficial role in the human body such as immune-modulation, antioxidant activity, ACE-inhibitory activity, anti-neoplastic, anti-microbial, etc. In milk, bioactive peptides may either be present in their natural form or released from their parental proteins due to enzymatic action. The increasing interest in bioactive peptides among researchers has lately augmented the exploration of minor dairy species such as sheep, goat, camel, mithun, mare, and donkey. Alternative to cow, milk from minor dairy species have also been proven to be healthier from infancy to older age owing to their higher digestibility and other nutritive components. Therefore, realizing the significance of milk from such species and incentivized interest towards the derivatization of bioactive peptides, the present review highlights the significant research achievements on bioactive peptides from milk and milk products of minor dairy species. Graphical abstract

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Angiotensin converting enzyme‐inhibitory activity and antimicrobial effect of fermented camel milk (Camelus dromedarius)

Cited by 36 publications

References 35 publications

In vitro investigation of anticancer, antihypertensive, antidiabetic, and antioxidant activities of camel milk fermented with camel milk probiotic: A comparative study with fermented bovine milk

In vitro investigation of anticancer, antihypertensive, antidiabetic, and antioxidant activities of camel milk fermented with camel milk probiotic: A comparative study with fermented bovine milk

Angiotensin-I Converting Enzyme Inhibition and Antioxidant Activity of Papain-Hydrolyzed Camel Whey Protein and Its Hepato-Renal Protective Effects in Thioacetamide-Induced Toxicity

A comprehensive review on bioactive peptides derived from milk and milk products of minor dairy species

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