Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with vasoocclusive complications of sickle cell anemia

Mahjoub, Sana; Abdelrhman, Enaam; El-Deen, Mohammed Elfatih Mohy; Mustafa, Mustafa Sharf Eldin; Ali, Elshazali Widaa

doi:10.4103/2229-516x.192594

Cited by 2 publications

References 14 publications

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Evaluation of Current Clinical Research Spectrum of Sickle Cell Anemia to Approach New Innovative Developmental Techniques for Enhancing Sudanese Health Systems

Salih

Saad

Eldouch³

et al. 2022

Preprint

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Background Sickle cell Anemia and/or Disease (SCA/SCD) is an autosomal recessive disease leading to abnormal hemoglobin with global prevalence in general and tribal burden in sub-Saharan Africa particularly. Methods Recent patients’ assessments were done using routine diagnostic protocols for SCA monitoring and manifestations. Insight of the physicians towards innovative techniques at the molecular level were done to enhance medical performance of the disease investigations. The online questionnaire showed the response and acceptance levels of the physicians to introduced innovative techniques in integration with current clinical and laboratory’s spectrums. Data interpretation and statistical analysis were done using IBM-SPSS ver 25 and MS. Excel 2019. Results Clinical manifestation showed painful crises, (Hand and food syndrome) and enuresis were observed in more than half of the patients, while stroke observed only in 5.5%. A strong association was observed in males regarding Hb vs RBC and MCV vs HbA2.However. females show an association between MCV vs HbA2 only. SCA current spectrum include CBC, BF and Solubility Sickling Test showed significant results in Hemoglobin P < 0.05 and Strong association was observed between Hb vs RBC, MCV vs HbA2 for males and MCV vs HbA2 for female only. Polymerase Chain Reaction (PCR) was introduced to detect inherited polymorphic traits in infants and parents beside the flow cytometry gave a detailed informatic image for the up normal blood cells shape and amounts comparing with normal ones. The high response of the online questionnaire (100%) showed the attitude of doctors and related staff accepting innovative techniques for enhancing current health system. Conclusions Although the current clinical and laboratory diagnostic protocols are effective for diagnosing SCA, the follow-up and treatment but the approach of innovative techniques is highly demanded for detecting un-seen symptoms and hidden polymorphic traits, beside monitoring all patients with including other family members.

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Evaluation of Current Clinical Research Spectrum of Sickle Cell Anemia to Approach New Innovative Developmental Techniques for Enhancing Sudanese Health Systems

Salih

Saad

Eldouch³

et al. 2022

Preprint

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Angiotensin Converting Enzyme Insertion/Deletion Polymorphism is Associated with Breast Cancer Risk: A Meta-Analysis

Moghimi

Kargar

Jafari

et al. 2018

Asian Pac J Cancer Prev

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Background:A number of case-control studies were conducted to investigate the association of angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism with breast cancer. But the results remain controversial. This meta-analysis aims to comprehensively evaluate the association of ACE I/D polymorphism with breast cancer.Method:A comprehensive literature search on PubMed, Google Scholar, SCOPUS and ISI Web of Knowledge databases for studies published up to June 01, 2018 was performed. Summary odds ratios (ORs) and 95% confidence intervals (CI) were estimated. Publication bias of literatures was evaluated using funnel plots and Egger’s test.Results:A total of 20 studies including 2846 breast cancer cases 9299 controls meeting the predefined criteria were involved in the meta-analysis. Overall, the ACE I/D polymorphisms was significantly associated with breast cancer under the allele model (I vs. D: OR= 0.803, 95% CI 0.647-0.996, p=0.046), the homozygote model (II vs. DD: OR= 0.662, 95% CI 0.462-0.947, p=0.024), the heterozygote model (ID vs. DD: OR= 0.707, 95% CI 0.528-0.946, p=0.020), the dominant model (II+ID vs. DD: OR= 0.691, 95% CI 0.507-0.941, p=0.019). In the subgroup analysis by ethnicity, a significant association was found among Asian and Caucasian populations, but not among mixed populations.Conclusions:This meta-analysis suggests that ACE I/D polymorphism may be associated with increased risk of breast cancer, especially among Asian and Caucasians. However, well-designed studies with larger sample size and more ethnic groups are needed to further validate the results.

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Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with vasoocclusive complications of sickle cell anemia

Cited by 2 publications

References 14 publications

Evaluation of Current Clinical Research Spectrum of Sickle Cell Anemia to Approach New Innovative Developmental Techniques for Enhancing Sudanese Health Systems

Evaluation of Current Clinical Research Spectrum of Sickle Cell Anemia to Approach New Innovative Developmental Techniques for Enhancing Sudanese Health Systems

Angiotensin Converting Enzyme Insertion/Deletion Polymorphism is Associated with Breast Cancer Risk: A Meta-Analysis

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