Angiotensin I-converting enzyme inhibitor from Grifola frondosa

Choi, Hye-Jin; Cho, H.Y; Yang, Hua; Ra, Kircher; Suh, Hyung Joo

doi:10.1016/s0963-9969(00)00149-6

Cited by 99 publications

(64 citation statements)

References 24 publications

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“…[22][23][24][25] In addition, there have also been a few reports on non-peptidyl ACE inhibitors such as polyphenol, which is found in foods such as mushroom, ashitaba, and garlic. [26][27][28] FBE contains a high level of polyphenol, 850 mg/100 mL. 10) FBEP exhibited angiotensin I-converting enzyme inhibitory activity with an IC50 value 68.3 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats

Ardiansyah

Shirakawa

Giriwono

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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We studied the effects of fermented barley extract P (FBEP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male 10-week-old SHRSP were divided into three groups that were fed: an AIN-93M diet (control), a low dose of FBEP (4 g/kg; FBEP1), and a high dose of FBEP (20 g/kg; FBEP2) for three weeks. Hypertension was significantly improved by the use of FBEP supplementation. The FBEP diet improved plasma triglyceride, insulin sensitivity, enhanced plasma catalase, and superoxide dismutase activities, and decreased plasma 8-hydroxy-2′-deoxyguanosine levels. In addition, the FBEP diet upregulated hepatic antioxidative genes and modulated Nrf2 protein levels in the liver. Furthermore, a single oral dose of FBEP (2 g/kg body weight) was able to lower blood pressure in SHRSP. In conclusion, our data suggest that increased expression of hepatic antioxidative genes and modulation of Nrf2 may play a role in the regulation of metabolic diseases in SHRSP consuming a FBEP diet.

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Section: Discussionmentioning

confidence: 99%

Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats

Ardiansyah

Shirakawa

Giriwono

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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“…Effect of some digestive enzymes on the ACE inhibitory peptide Theeffect of trypsin and pepsin on the activity of the ACE inhibitory peptidewas determined as described by Choi et al (2001).…”

Section: Effect Of Ph and Temperature On Ace Inhibitory Peptidementioning

confidence: 99%

“…This may be attributed to variations in the type of ACE-inhibitory peptides liberated after treating with different enzymes (Barbana and Boye, 2011). Studies have shown that a decrease in ACE inhibitory activity of a peptide after treatment with gastrointestinal enzymes does not make it ineffective, as they may still maintain their inhibitory activity (Choi et al, 2001). Fujita and Yoshikawa (1999) attributed this to the fact that other factors such as route of administration, food matrix and intestinal absorption play a significant role in the activity of the peptide.…”

Section: K+ Edta Ca2+mentioning

confidence: 99%

Partial purification and characterization of angiotensin converting enzyme inhibitory peptide from scarlet runner beans (<i>Phaseolus coccineus</i>) seeds

Abdulazeez¹,

Osumeje²,

Kurfi³

2017

Bayero J. Pure App. Sci.

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In the present study, an angiotensin seedpods of scarlet runner beans (Phaseolus coccineus) was partially process: acetone precipitation and gel filtration chromatography. The ACE inhibitory activities of all fractions were determined by a spectrophotometric method. The amino acid composition, effect of temperature, pH, digestive enzymes and metal ions on the activity of the partially were determined. From the results, the crude proteins from seedpod specific inhibitoryactivity of 0.064±0.004μmol/min/mg after acetone precipitation. Gel filtration chromatography with sephadex G-50 further increased the specific inhibitory activity purification fold of 3.40 and yield of Glutamic acid at 13.63g/100g protein being highest. The optimum pH and temperature of the peptide was 7.0 and 40 0 C, respecti inhibited by Na + , Mg 2+ , K + , and Ca (p<0.05) decreased the activity of the partially shown that angiotensin-converting enzyme coccineus, but the purification steps needs to be modified to obtain a peptide with higher yield.

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“…Crude ACE solution was stored in a freezer at −70C until the experiment. ACE inhibitory activity was determined by modifying the method of Choi et al (2001). A mixture of 100 mM sodium borate buffer (pH 8.3), 300 mM sodium chloride (NaCl), crude ACE solution and an appropriate amount of sample was preincubated for 10 min at 37C.…”

Section: Ace Inhibition Assaymentioning

confidence: 99%

In Vitro Inhibitory Potential Against Key Enzymes Relevant for Hyperglycemia and Hypertension of Red Pepper (Capsicum annuum L.) Including Pericarp, Placenta, and Stalk

Chen

Kang

2013

Journal of Food Biochemistry

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Extracts from the pericarp, placenta and stalk of red pepper (Capsicum annuum L) were investigated to determine their antioxidant and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension. We examined the total phenolic and capsaicin content in red pepper extract. Anti-hyperglycemia relevant in vitro α-glucosidase inhibitory activity correlated strongly to the antioxidant activity measured by the 1, 1-diphenyl-2-picrylhydrazyl method. The high phenolic and capsaicin content-containing red pepper stalk was found to have strong α-amylase and strong α-glucosidase inhibitory effects. The pericarp and placenta had high angiotensin I-converting enzyme (ACE) inhibitory activity and also had good α-glucosidase inhibitory profiles. Inhibition of these enzymes provides a strong biochemical basis for the management of type 2 diabetes by controlling glucose absorption and reducing associated hypertension, respectively. PRACTICAL APPLICATIONSThe inhibitory effect on key enzymes relevant for hyperglycemia (α-glucosidase and α-amylase) and hypertension (ACE) of the red pepper pericarp, placenta and stalk was investigated in this study. The in vitro inhibitory activities of α-amylase, α-glucosidase and ACE provide a strong biochemical rationale for further in vivo studies for type 2 diabetes through the control of glucose absorption and for the reduction of the associated hypertension. Furthermore, red pepper stalk, which has always been considered as an agricultural waste product, was an effective inhibitor of α-glucosidase and α-amylase. This study shows the potential of this agricultural waste product as a food additive and therapeutic agent for clinical applications.

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Angiotensin I-converting enzyme inhibitor from Grifola frondosa

Cited by 99 publications

References 24 publications

Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats

Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats

Partial purification and characterization of angiotensin converting enzyme inhibitory peptide from scarlet runner beans (<i>Phaseolus coccineus</i>) seeds

In Vitro Inhibitory Potential Against Key Enzymes Relevant for Hyperglycemia and Hypertension of Red Pepper (Capsicum annuum L.) Including Pericarp, Placenta, and Stalk

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