Angiotensin II, aldosterone and arterial pressure: a quantitative approach. Arthur C. Corcoran Memorial Lecture.

Brown, J. J.; Casals-Stenzel, J.; Cumming, A. M. M.; Davies, D. L.; Fraser, Robert; Lever, A. F.; Morton, J. J.; Semple, P. F.; Tree, M.; Robertson, J. I. S.

doi:10.1161/01.hyp.1.3.159

Cited by 66 publications

(13 citation statements)

References 124 publications

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“…They interpreted this to indicate that BP was maintained by a slowly developing hypersensitivity to angiotensin II. 17 In this and previous work," we found no evidence of such a slow reversal of hypertension. Although the BP did fall following unclipping or nephrectomy during more prolonged inhibition of the renin-angiotensin system in the present experiments, this fall was similar to that observed in animals undergoing infusion with dextrose alone.…”

Section: Discussioncontrasting

confidence: 42%

Surgical reversal of two-kidney one clip hypertension during inhibition of the renin-angiotensin system.

Russell¹,

Bing²,

Thurston³

et al. 1982

Hypertension

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SUMMARY Conscious rats with two-kidney one dip Goldblatt hypertension had the constricting dip removed during continuous infusion of either dextrose, saralasin, or captopril. Other dextrose-infused animals underwent removal of the ischemic kidney or a sham procedure. Direct arterial blood pressure (BP) was recorded throughout the 15-hour preoperative and subsequent 24-hour postoperative period. Rats were studied in the "early" phase (1-3 weeks duration) or "chronic" phase (> 4 months) of hypertension. Animals subjected to a sham procedure returned to preoperative BP values. The BP of animals undipped or nephrectomlzed did not return to previous hypertensive levels. Instead, a biphasic response was seen where BP partially recovered from an operative fall and then slowly declined to normal at 24 hours; this effect occurred in both stages of hypertension. At 24 hours, removal of the ischeraic kidney was as effective as removal of the constricting dip in the correction of both eariy and chronic phase hypertension. Rats infused with saralasin or captopril demonstrated an acute (within 2 hours) and sustained fall in BP, but not to nonnotensive levels. This fall was significant In all animals (p < 0.01) apart from chronic phase rats infused with saralasin where no significant fall was seen. Although animals infused with saralasin or captopril commenced at a lower preoperative BP, the biphasic pattern of response to undipping was identical to that of dextrose-infused undipped rats. Thus, sustained inhibition of the renin-angiotensin system did not modify the correction of hypertension produced by removal of the constricting clip, and the response to surgical correction did not appear to be entirely mediated by changes in the activity of the renin-angiotensin system, particularly in the chronic stage. Equally, the rapidity of correction is not consistent with a role for vascular hypertrophy. (Hypertension 4: 69-76, 1982)

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Section: Discussioncontrasting

confidence: 42%

Surgical reversal of two-kidney one clip hypertension during inhibition of the renin-angiotensin system.

Russell¹,

Bing²,

Thurston³

et al. 1982

Hypertension

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show abstract

“…Several procedures have been proposed with the aim of provoking renin secretion and thus enhancing both peripheral renin levels and the renal vein renin differential." However, we deliberately did not employ such maneuvers because we wanted quantitative data that could be related to similar measurements made in other recumbent patients and normal volunteers 5 under comparable circumstances.…”

Section: Discussionmentioning

confidence: 99%

Renal artery stenosis with normal angiotensin II values. Relationship between angiotensin II and body sodium and potassium on correction of hypertension by captopril and subsequent surgery.

Atkinson¹,

Brown²,

Davies³

et al. 1981

Hypertension

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SUMMARYThe case is reported of a young woman with severe hypertension, unilateral renal artery stenosis, variously normal or marginally high plasma concentrations of active renin, angiotensin II, aldosterone, sodium, and potassium; and normal total exchangeable and total body sodium and potassium. Arteriograms and ureter catheterization showed the stenosis to be severe, but the unstimulated renal vein renin and angiotensin II differential to be modest. Captopril caused an initial fall in angiotensin II and arterial pressure. During prolonged captopril treatment, plasma angiotensin II and aldosterone remained depressed; exchangeable and total body sodium and potassium were unaltered. Blood pressure fell further to normal levels during prolonged captopril treatment, while subsequent surgical correction of the renal artery stenosis was curative; absolute values of blood pressure and plasma angiotensin II were similar in both situations.

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“…Ang II regulates circulating blood volume (41) and stimulates neovascularization (42) and cell proliferation (21). Renin, an enzyme that produces angiotensin, is found in cancer blood vessels (43), and long-term administration of angiotensin-converting enzyme (ACE) inhibitors, antihypertensive agents (44), reduces morbidity and mortality in cancer patients (45). A recent study reports that specific COX-2 inhibitors and ACE inhibitors synergistically reduce tumor growth in an in vivo mouse model for colon cancer (46).…”

mentioning

confidence: 99%

Angiotensin II and Epidermal Growth Factor Induce Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Small GTPases Using Distinct Signaling Pathways

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Chiu

Rozengurt

2005

Journal of Biological Chemistry

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Angiotensin II, aldosterone and arterial pressure: a quantitative approach. Arthur C. Corcoran Memorial Lecture.

Cited by 66 publications

References 124 publications

Surgical reversal of two-kidney one clip hypertension during inhibition of the renin-angiotensin system.

Surgical reversal of two-kidney one clip hypertension during inhibition of the renin-angiotensin system.

Renal artery stenosis with normal angiotensin II values. Relationship between angiotensin II and body sodium and potassium on correction of hypertension by captopril and subsequent surgery.

Angiotensin II and Epidermal Growth Factor Induce Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Small GTPases Using Distinct Signaling Pathways

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