Angiotensin II stimulates sperm motility

Vinson, Gavin P.; Mehta, Jayant; Evans, Stephen; Matthews, Sarah; Puddefoot, J. R.; Sarıdoğan, Ertan; Holt, William V.; Djahanbakhch, O.

doi:10.1016/s0167-0115(96)00118-8

Cited by 42 publications

(40 citation statements)

References 15 publications

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“…The motility-influencing abilities of endogenous peptides such as angiotensin (Vinson et al, 1995(Vinson et al, , 1996 and substance P (Sastry et al, 1991) have been established, whereas corresponding effects of Bk are discussed controversially. The motility-influencing abilities of endogenous peptides such as angiotensin (Vinson et al, 1995(Vinson et al, , 1996 and substance P (Sastry et al, 1991) have been established, whereas corresponding effects of Bk are discussed controversially.…”

Section: Discussionmentioning

confidence: 99%

Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes

Siems¹,

Maul²,

Wiesner³

et al. 2003

Andrologia

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Effects of kinins, mainly bradykinin (Bk), and other components of the kallikrein-kinin system on sperm motility and further fertility-related functions have been described repeatedly. However, reported data are in part controversial and the mechanism of kinin effects on sperm motility is not yet understood. In the present report we describe a significant promoting effect of Bk on sperm motility at subnanomolar concentrations. This effect was stabilized and even increased by suppression of Bk hydrolysis in semen samples. As sperm membrane-bound angiotensin-converting enzyme and neutral metalloendopeptidase are mainly involved in Bk hydrolysis, an effective cocktail of enzyme inhibitors promoting the sperm motility consists of phosphoramidon and lisinopril (both at 10-7 m). The effects of Bk on sperm cells are not mediated by the B2 Bk receptor. Using several biochemical, molecular and genetic methods we could not detect any Bk receptor on spermatozoa.

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Section: Discussionmentioning

confidence: 99%

Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes

Siems¹,

Maul²,

Wiesner³

et al. 2003

Andrologia

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“…AngII induced acrosomal exocytosis only in capacitated sperm. AngII has been shown to maintain sperm motility via an AT 1 receptor-mediated mechanism (Vinson et al 1995(Vinson et al , 1996. However, some studies with ACE inhibitors or AngII receptor antagonists have reported no effect on fertility in rats (Dostal et al 1991, Spence et al 1995.…”

Section: Ras and Male Fertilitymentioning

confidence: 99%

The renin-angiotensin system and male reproduction: new functions for old hormones

Leung¹,

Sernia²

2003

Journal of Molecular Endocrinology

105

101

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The blood-borne renin-angiotensin system (RAS) is known best for its role in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, numerous tissues show intrinsic angiotensin-generating systems that cater for specific local needs through actions that add to, or differ from, the circulating RAS. The male reproductive system has several sites of intrinsic RAS activity. Recent focus on the epididymis, by our laboratories and by others, has contributed important details about the local RAS in this tissue. The RAS components have been localized morphologically and topographically; they have been shown to be responsive to androgens and to hypoxia; and angiotensin has been shown to influence tubular, and consequently, fluid secretion. Components of the RAS have also been found in the testis, vas deferens, prostate and semen. Angiotensin II receptors, type 1 and, to a lesser extent, type 2 are widespread, and angiotensin IV receptors have been localized in the prostate. The roles of the RAS in local processes at these sites are still uncertain and have yet to be fully elucidated, although there is evidence for involvement in tubular contractility, spermatogenesis, sperm maturation, capacitation, acrosomal exocytosis and fertilization. Notwithstanding this evidence for the involvement of the RAS in various important aspects of male reproduction, there has so far been a lack of clinical evidence, demonstrable by changes in fertility, for a crucial role of the RAS in male reproduction. However, it is clear that there are several potential targets for manipulating the activity of the male reproductive system by interfering with the locally generated angiotensin systems.

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“…Somatic ACE and other components of the RAS are also found in male reproductive tissues (Leydig cells, seminiferous tubules, epididymis, testis and prostate gland) with the prostate being a likely source of the angiotensin II that has been found in human seminal fluid (Leung and Sernia, 2003;O'Mahony et al, 2005;O'Mahony et al, 2000). Angiotensin II might affect fertility in the human male because of its ability to stimulate sperm motility, induce the acrosome reaction and increase oocyte penetration (Kohn et al, 1997;Kohn et al, 1998;Vinson et al, 1996;Vinson et al, 1995). By contrast, the pronounced male infertility of mice lacking germinal ACE is independent of the RAS and probably results from failure to cleave a peptide distinct from angiotensin I (Fuchs et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Male accessory glands of Drosophila melanogaster make a secreted angiotensin I-converting enzyme (ANCE), suggesting a role for the peptide-processing enzyme in seminal fluid

Rylett

Walker

Howell

et al. 2007

Journal of Experimental Biology

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SUMMARY Angiotensin I-converting enzyme (ACE) expressed on the surface of endothelial cells is responsible for the last step in the synthesis of circulating angiotensin II and the inactivation of bradykinin. Mammalian ACE is also expressed in the prostate with other components of the renin–angiotensin system, and in developing spermatids, where the peptidase activity is known to be critical for normal sperm function. The importance of an ACE gene to male fertility has also been demonstrated in Drosophila melanogaster, where Ance is expressed in spermatids, and hypomorphic alleles of Ance cause a defect in spermiogenesis. Here we show that ANCE, which shares many enzymatic properties with mammalian ACE, is also a product of the male accessory gland of D. melanogaster. It is expressed in the secondary cells and is associated with the electron dense granule within the large vesicles of these cells. ACE proteolytic activity is lost from the accessory glands during mating,consistent with transfer to the mated female in the seminal fluid. The accessory gland ACE-like activity might have an evolutionarily conserved function processing biologically active peptides with a role in male fertility.

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Angiotensin II stimulates sperm motility

Cited by 42 publications

References 15 publications

Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes

Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes

The renin-angiotensin system and male reproduction: new functions for old hormones

Male accessory glands of Drosophila melanogaster make a secreted angiotensin I-converting enzyme (ANCE), suggesting a role for the peptide-processing enzyme in seminal fluid

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