Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue

Ohki, Kohji; Wakui, Hiromichi; Kishio, Nozomu; Azushima, Kengo; Uneda, Kazushi; Haku, Sona; Kobayashi, Ryu; Haruhara, Kotaro; Kinguchi, Sho; Yamaji, Takahiro; Yamada, Takayuki; Minegishi, Shintaro; Ishigami, Tomoaki; Toya, Yoshiyuki; Yamashita, Akio; Imajo, Kento; Nakajima, Atsushi; Kato, Ikuo; Ohashi, Kenichi; Tamura, Kouichi

doi:10.1038/s41598-018-21270-8

Cited by 20 publications

(16 citation statements)

References 49 publications

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“…Immunoblot analysis was performed as described previously 48,51 . Briefly, total protein extract was performed from kidney tissues with sodium dodecyl sulfate-containing sample buffer.…”

Section: Methodsmentioning

confidence: 99%

Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice

Azushima

Uneda

Wakui

et al. 2019

Sci Rep

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The underlying pathogenesis of chronic kidney disease involves an activated renin-angiotensin system and systemic inflammation which ultimately develop renal injury. Rikkunshito (RKT) has been reported to exert anti-fibrotic and anti-inflammatory effects through enhancement of ghrelin signaling pathway. In this study, we investigated the effects of RKT on renal fibrosis and inflammation in angiotensin II (Ang II)-induced renal injury model. Ang II-infused mice exhibited hypertension, cardiac hypertrophy, increases in blood urea nitrogen and serum creatinine, moderate albuminuria and renal pathological changes such as mild urinary cast, interstitial macrophage infiltration and modest interstitial fibrosis. RKT had no evident effects on the Ang II-induced renal functional insufficiency and fibrosis, but attenuated renal interstitial macrophage infiltration. In addition, RKT significantly restored the Ang II-induced alteration in the expression of renal fibrosis- and inflammation-related genes such as type 3 collagen, transforming growth factor-β, monocyte chemoattractant protein-1 and interleukin-6. Furthermore, although RKT did not affect the expression of renal ghrelin receptor, an Ang II-induced decrease in renal sirtuin 1 expression, a critical down-stream pathway of the ghrelin receptor, was restored by RKT. These findings suggest that RKT potentially has a renal anti-inflammatory effect in the development of renal injury, and this effect could be mediated by the ghrelin signaling pathway.

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“…Immunoblot analysis was performed as described previously 48,51 . Briefly, total protein extract was performed from kidney tissues with sodium dodecyl sulfate-containing sample buffer.…”

Section: Methodsmentioning

confidence: 99%

Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice

Azushima

Uneda

Wakui

et al. 2019

Sci Rep

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“…Moreover, FA binding protein 4 (FABP4) inhibitor reduces FA-induced ER stress-associated inflammation in skeletal muscles by reducing p38 MAPK activation [202]. Additionally, angiotensin II induces insulin resistance in skeletal muscle by a mechanism dependent on oxidative stress and activation of p38, which results in decreased function of glucose transporter type 4 [203]. On the other hand, the deletion of MKP-1, which results in the activation of p38s and JNKs, leads to increased oxidative metabolism in muscles and elevated energy expenditure in mice and thus prevents obesity and insulin resistance [204].…”

Section: P38s In Regulation Of Skeletal Muscle Functionmentioning

confidence: 99%

Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases

Kassouf

Sumara

2020

Biomolecules

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The family of mitogen-activated protein kinases (MAPKs) consists of fourteen members and has been implicated in regulation of virtually all cellular processes. MAPKs are divided into two groups, conventional and atypical MAPKs. Conventional MAPKs are further classified into four sub-families: extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK1, 2 and 3), p38 (α, β, γ, δ), and extracellular signal-regulated kinase 5 (ERK5). Four kinases, extracellular signal-regulated kinase 3, 4, and 7 (ERK3, 4 and 7) as well as Nemo-like kinase (NLK) build a group of atypical MAPKs, which are activated by different upstream mechanisms than conventional MAPKs. Early studies identified JNK1/2 and ERK1/2 as well as p38α as a central mediators of inflammation-evoked insulin resistance. These kinases have been also implicated in the development of obesity and diabetes. Recently, other members of conventional MAPKs emerged as important mediators of liver, skeletal muscle, adipose tissue, and pancreatic β-cell metabolism. Moreover, latest studies indicate that atypical members of MAPK family play a central role in the regulation of adipose tissue function. In this review, we summarize early studies on conventional MAPKs as well as recent findings implicating previously ignored members of the MAPK family. Finally, we discuss the therapeutic potential of drugs targeting specific members of the MAPK family.

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“…Similarly, RAMP2 (fold change = 1.69) that complex with calcitonin receptor-like receptor is important to regulate the activity of adrenomedullin, a hypotensive compound [50, 51]. AGTRAP overexpression has also been associated with insulin resistance [52]. This is particularly intriguing knowing that chickens are less sensitive to high plasma glucose concentration as compared with mammals, while maintaining similar insulin plasma levels [53].…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis of transcriptomic data related to the liver of laying hens: from physiological basics to newly identified functions

et al. 2019

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BackgroundAt sexual maturity, the liver of laying hens undergoes many metabolic changes to support vitellogenesis. In published transcriptomic approaches, hundreds of genes were reported to be overexpressed in laying hens and functional gene annotation using gene ontology tools have essentially revealed an enrichment in lipid and protein metabolisms. We reanalyzed some data from a previously published article comparing 38-week old versus 10-week old hens to give a more integrative view of the functions stimulated in the liver at sexual maturity and to move beyond current physiological knowledge. Functions were defined based on information available in Uniprot database and published literature.ResultsOf the 516 genes previously shown to be overexpressed in the liver of laying hens, 475 were intracellular (1.23–50.72 fold changes), while only 36 were predicted to be secreted (1.35–66.93 fold changes) and 5 had no related information on their cellular location. Besides lipogenesis and protein metabolism, we demonstrated that the liver of laying hens overexpresses several clock genes (which supports the circadian control of liver metabolic functions) and was likely to be involved in a liver/brain/liver circuit (neurotransmitter transport), in thyroid and steroid hormones metabolisms. Many genes were associated with anatomical structure development, organ homeostasis but also regulation of blood pressure. As expected, several secreted proteins are incorporated in yolky follicles but we also evidenced that some proteins are likely participating in fertilization (ZP1, MFGE8, LINC00954, OVOCH1) and in thyroid hormone maturation (CPQ). We also proposed that secreted proteins (PHOSPHO1, FGF23, BMP7 but also vitamin-binding proteins) may contribute to the development of peripheral organs including the formation of medullar bones to provide labile calcium for eggshell formation. Thirteen genes are uniquely found in chicken/bird but not in human species, which strengthens that some of these genes may be specifically related to avian reproduction.ConclusionsThis study gives additional hypotheses on some molecular actors and mechanisms that are involved in basic physiological function of the liver at sexual maturity of hen. It also revealed some additional functions that accompany reproductive capacities of laying hens, and that are usually underestimated when using classical gene ontology approaches.

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Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue

Cited by 20 publications

References 49 publications

Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice

Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice

Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases

Integrative analysis of transcriptomic data related to the liver of laying hens: from physiological basics to newly identified functions

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