Angiotensin-induced dringking: Sexual differences

Vijande, M.; Costales, M.; Schiaffini, O; Marín, B

doi:10.1016/0091-3057(78)90278-2

Cited by 20 publications

(13 citation statements)

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“…Estrogen produces a rapid and persistent in crease in plasma renin substrate [39], However, plasma AT and plasma renin activity were the same following es trogen treatment of OVX rats [40], In rats, AT-induced drinking varies with the estrous cycle and with estrogen treatment and female rats drink more in response to AT than do male rats [41][42][43], However, in vivo experiments do not distinguish between direct actions of estrogen on the pituitary and indirect mechanisms involving, for example, the peripheral renin-angiotensin system or hy pothalamic hormone release. Moreover, the effect of estrogen on AT receptor expression is tissue-dependent.…”

Section: Discussionmentioning

confidence: 99%

Estrogens Regulate Angiotensin-Converting Enzyme and Angiotensin Receptors in Female Rat Anterior Pituitary

et al. 1992

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We studied the effects of the estrous cycle, ovariectomy and estrogen replacement on angiotensin-converting enzyme (ACE) (kininase II, EC 3.4.15.1) and angiotensin II (AT) receptors in the pituitary gland of the female rat. Quantitative autoradiography, with the use of consecutive pituitary sections, allowed for simultaneous determination of changes in binding and in the potential AT synthetic ability of individual pituitaries, and for a correlation between these two phenomena. In the anterior pituitary, ACE activity and binding of the ACE inhibitor [¹²⁵I]-351A were not changed during the estrous cycle. Ovariectomy produced a significant increase in ACE activity and binding, and both of these parameters returned to normal after estrogen replacement. There were no changes in ACE activity or binding in the posterior pituitary during the estrous cycle or after ovariectomy or hormone replacement. AT receptors were characterized as of the AT₁ type, since they were displaced by the selective AT₁ antagonist DuP 753 and not by the AT₂ competitor PD 123177. There were marked changes in the concentration of AT₁ receptors during the estrous cycle, with highest numbers in metestrus, lower in estrus and diestrus, and lowest during proestrus. Estrogen replacement in ovariectomized rats decreased AT₁ receptor number in the anterior pituitary. Our results indicate a dual effect of estrogen on anterior pituitary AT, physiologically on AT receptor expression and pharmacologically on ACE activity.

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Section: Discussionmentioning

confidence: 99%

Estrogens Regulate Angiotensin-Converting Enzyme and Angiotensin Receptors in Female Rat Anterior Pituitary

et al. 1992

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“…The expression of such a sex difference was probably the consequence of a significant decrease in fluid intake shown by male mice entering the Middle adolescence phase (for literature and discussion on the differential effects of sex hormones on drinking behavior, see Fernandez-Trisac et al 1998;Vijande et al 1978). As for body growth rate, Early adolescent mice were associated with elevated levels of daily body-weight gain, which eventually decreased later on (by pnd 30 for females and by pnd 32 for males), as a possible consequence of the onset of puberty.…”

Section: Fluid Intake and Body Growth Ratementioning

confidence: 99%

Peculiar Vulnerability to Nicotine Oral Self-administration in Mice during Early Adolescence

Adriani

Macrı̀

Pacifici

et al. 2002

Neuropsychopharmacology

196

142

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(10 mg/l). After a 6-day period, a fading study was carried out, in which nicotine concentration was reduced to 7 mg/l (days 7-9) and 5 mg/l (days 10-12), to assess whether animals would compensate by increasing their intake from the nicotine solution. In Experiment 2, psychopharmacological effects on locomotion induced by the nicotine solution (0, 10, 30 mg/l) Recent research has emphasized that adolescence is associated with patterns of temporary deviance (Arnett 1992) and the use of various kinds of psychoactive agents (Mathias 1996). Drug abuse in adolescents ranging from 11-12 to 17-18 years of age is likely to start with tobacco smoking, which can be followed by marijuana and/or 1991;Breslau et al. 1993;Nides et al. 1995;Kandel and Chen 2000). Despite the social and scientific importance of deepening our knowledge of this issue (see e.g. Colby et al. 2000), there have been very few investigations on the psychobiological factors contributing to the specific adolescence-related willingness to experience various psychoactive drugs (for a review, see Laviola et al. 1999;Spear 2000). For the purpose of laboratory studies, a suitable animal model of human adolescence is available in rodents. Namely, periadolescence is classically defined as the ontogenetic period that encompasses the week preceding the onset of puberty and the first few days thereafter (Spear and Brake 1983). Periadolescent rodents differ markedly from adults in their spontaneous behavioral repertoire (Cirulli et al. 1996;Terranova et al. 1993;Meaney and Stewart 1981;Panksepp 1981). In fact, elevated levels of novelty seeking and a reduced behavioral and hormonal response to stress (Adriani et al. 1998;Adriani and Laviola 2000) are exhibited by animals around this age. A characteristic hyporesponsivity to the effects of an acute administration of psychostimulants (Spear and Brake 1983;Laviola et al. 1995;Bolanos et al. 1998;Adriani and Laviola 2000), a peculiar pattern of behavioral sensitization following repeated drug exposure (Laviola et al. 1995(Laviola et al. , 2001Adriani et al. 1998), as well as a weak drug-induced place conditioning profile (Adriani et al. 1998;Bolanos et al. 1996Bolanos et al. , 1998 but see Campbell and Spear 2000), are also reported. Based on these findings, an increased vulnerability to the addictive properties of abused drugs has been suggested to be typical of adolescence in both humans and animals models (see Laviola et al. 1999).In the present study, we were interested in nicotine, which beside being the main psychoactive compound implied in tobacco smoking, also shares most of the characteristics of other addictive drugs (Corrigall et al. 1992(Corrigall et al. ,1994Pontieri et al. 1996;Merlo-Pich et al. 1997;Stolerman 1999). Nicotine's effects in mice have been shown to be highly dependent on the genetic background (see Marks et al. 1989;Robinson et al. 1996). However, the interaction between the pharmacological effects and the incentive properties of nicotine during the adolescent period has been largel...

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“…We limited our testing to male rats and female rats in estrus to focus on a time in the cycle during which estrogens influence intake (Danielsen and Buggy, 1980). Furthermore, earlier studies found that female rats, either in estrus or diestrus, drank more than did male rats, obviating the need to include both estrus and diestrus females the present study design (Vijande et al, 1978). Because AngII stimulates saline intake in addition to water intake (Daniels and Fluharty, 2009), we performed additional experiments using two-bottle tests to measure the dose-response relationship between AngII and intake when both water and saline were available.…”

Section: Introductionmentioning

confidence: 97%

“…Fluid intake stimulated by AngII is also affected by sex, however, there are conflicting reports in the literature about the direction of this sex difference and many unanswered questions remain. For example, when hormones are experimentally manipulated, estradiol-primed OVX females were found to drink less than males (Jonklaas and Buggy, 1984), but earlier studies reported that cycling females, in all stages of the estrous cycle, drank more than males (Kaufman, 1980; Vijande et al, 1978). Finally, others have reported no sex difference in fluid intake after AngII treatment (Sun et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the drinking response to angiotensin II (AngII): Effect of body weight

Santollo

Torregrossa

Daniels

2017

Hormones and Behavior

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Sex differences in fluid intake stimulated by angiotensin II (AngII) have been reported, but the direction of the differences is inconsistent. To resolve these discrepancies, we measured water intake by male and female rats given AngII. Males drank more than females, but when intake was normalized to body weight, the sex difference was reversed. Weight-matched males and females, however, had no difference in intake. Using a linear mixed model analysis, we found that intake was influenced by weight, sex, and AngII dose. We used linear regression to disentangle these effects further. Comparison of regression coefficients revealed sex and weight differences at high doses of AngII. Specifically, after 100ng AngII, weight was a predictor of intake in males, but not in females. Next, we tested for differences in AngII-induced intake in male and females allowed to drink both water and saline. Again, males drank more water than females, but females showed a stronger preference for saline. Drinking microstructure analysis suggested that these differences were mediated by postingestive signals and more bottle switches by the females. Finally, we probed for differences in the expression of components of the renin-angiotensin system in the brains of males and females and found sex differences in several genes in discrete brain regions. These results provide new information to help understand key sex differences in ingestive behaviors, and highlight the need for additional research to understand baseline sex differences, particularly in light of the new NIH initiative to balance sex in biomedical research.

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Angiotensin-induced dringking: Sexual differences

Cited by 20 publications

References 10 publications

Estrogens Regulate Angiotensin-Converting Enzyme and Angiotensin Receptors in Female Rat Anterior Pituitary

Estrogens Regulate Angiotensin-Converting Enzyme and Angiotensin Receptors in Female Rat Anterior Pituitary

Peculiar Vulnerability to Nicotine Oral Self-administration in Mice during Early Adolescence

Sex differences in the drinking response to angiotensin II (AngII): Effect of body weight

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