2008
DOI: 10.1007/s11010-008-9884-4
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Angiotensin metabolites can stimulate receptors of the Mas-related genes family

Abstract: The Mas protooncogene encodes a G protein-coupled receptor, we identified, also by using the specific angiotensin-(1-7) antagonist A-779, to be associated with intracellular signaling of the angiotensin (Ang) II metabolite Ang-(1-7). Recently, Mas-related genes (Mrg) have been identified coding for the Mrg-receptor family. All family members share high sequence homology to Mas. Most of them are orphan receptors. To proof whether structure similarities of the Mrg receptors with Mas turn them into potential rece… Show more

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Cited by 76 publications
(69 citation statements)
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“…11 A detailed description of techniques, where there is no reference by our group, is provided in full detail including cAMP measurement, quantification of protein kinase A (PKA) activity and cAMP response element-binding (CREB) phosphorylation, and measurement of acute hemodynamic effects.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…11 A detailed description of techniques, where there is no reference by our group, is provided in full detail including cAMP measurement, quantification of protein kinase A (PKA) activity and cAMP response element-binding (CREB) phosphorylation, and measurement of acute hemodynamic effects.…”
Section: Methodsmentioning
confidence: 99%
“…About 24 hours later, cells were transiently transfected with 100 ng eukaryotic expression vectors of AT1 11 , AT2 or Mrg together with 25 ng pNFAT-TA-Luc-, (BD Biosciences, Heidelberg, Germany) or pELK-Luc Reporter Vector (Signosis, Santa Clara, CA) luciferase reporter plasmids and 25 ng pRL-TK (Promega GmbH, Mannheim, Germany) using the protocol described above. Next day, the medium was replaced by serum-free medium 1 hour before stimulation.…”
Section: Dual-luciferase Reporter Assaymentioning
confidence: 99%
“…However, basal expression and activity of MAS and AT 1 R were detected in nontransfected or vector-control transfected COS7 cells (16,40,51). Therefore, in the present study, we tested the hypothesis that COS7 cells express a previously unrecognized, functional RAS.…”
Section: Discussionmentioning
confidence: 86%
“…Previous studies have suggested that COS7 cells lack endogenous AT 1 R, AT 2 R, and Mas receptors (3,4,16,23,28,30,40,51). However, basal expression and activity of MAS and AT 1 R were detected in nontransfected or vector-control transfected COS7 cells (16,40,51).…”
Section: Discussionmentioning
confidence: 92%
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