Angle-Closure Glaucoma as a Presumed Presenting Sign in Patients with Syphilis

Matsuo, Toshihiko; Taira, Yuki; Nagayama, Mikio; Baba, Tetsuya

doi:10.1016/s0021-5155(99)00196-3

Cited by 8 publications

(2 citation statements)

References 5 publications

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“…96 Evidence for its direct involvement in PAS formation, however, has yet to be revealed. Yet the development of PAS is highly associated with surgical procedures involving the anterior chamber, [97][98][99] trauma, 100 and inflammatory conditions, 101,102 circumstances in which TGF-␤ is likely to be activated. Thus, overexpression of TGF-␤, as we have shown in this study, may be directly involved in PAS formation.…”

Section: Peripheral Anterior Synechiaementioning

confidence: 99%

Ocular Gene Transfer of Active TGF-β Induces Changes in Anterior Segment Morphology and Elevated IOP in Rats

Robertson¹,

Golesic²,

Gauldie

et al. 2010

Invest. Ophthalmol. Vis. Sci.

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Purpose. Transforming growth factor beta (TGF-beta) is known to play a crucial role in wound healing and fibrotic tissue remodeling. A large body of evidence suggests a role for this cytokine in the pathogenesis of glaucoma; however, the mechanisms by which it affects anterior segment morphology are not well understood. Therefore, the purpose of this study was to examine the effects of TGF-beta overexpression on anterior segment morphology and subsequent effects on intraocular pressure. Methods. Adenoviral gene transfer was used to deliver active TGF-beta1 to the rat eye. Measurements of intraocular pressure were taken with a tonometer on days 0, 14, 21, and 29. Histologic analysis was undertaken to examine anterior segment morphology, and markers of matrix deposition and fibrosis were used. Results. Gene transfer of TGF-beta in the anterior segment resulted in the formation of peripheral anterior synechiae (PAS), which consisted of a fibroproliferative region of corneal endothelial cells, matrix accumulation, and decrease in trabecular meshwork expression of alpha-smooth muscle actin. These features were accompanied by ocular hypertension. Conclusions. Gene transfer of TGF-beta into the anterior segment induces aberrant PAS associated with the transition of corneal endothelial cells and subsequent matrix deposition. These features are highly reminiscent of human iridocorneal endothelial (ICE) syndrome. Gene transfer of TGF-beta can, therefore, be used to induce anatomic changes in the anterior segment in a rodent model that result in ocular hypertension.

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Section: Peripheral Anterior Synechiaementioning

confidence: 99%

Ocular Gene Transfer of Active TGF-β Induces Changes in Anterior Segment Morphology and Elevated IOP in Rats

Robertson¹,

Golesic²,

Gauldie

et al. 2010

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Matsuo and colleagues [28] resurrected observations made in the 1960s and 1970s that syphilitic interstitial keratitis can present as angle closure glaucoma. They described two patients, with apparently inactive syphilis and extensive peripheral anterior synechiae with angle closure glaucoma, and they hypothesize that the synechiae formed during the prior inflammatory episodes.…”

Section: Syphilitic Ocular Manifestationsmentioning

confidence: 99%