Angle Involvement and Glaucoma in Patients With Biopsy-Proven Iris Melanoma: A Response—Reply

Khan, Samira; Finger, Paul T.; Yu, Guo; Razzaq, Lubna; Jager, Martine J.; Keizer, R. J. W. De; Sandkull, Per; Seregard, Stefan; Gologorsky, Daniel; Schefler, Amy C; Murray, Timothy G.; Kivelä, Tero; Giuliari, Gian Paolo; McGowan, Hugh; Simpson, E. Rand; Corriveau, Christine; Coupland, Sarah E.; Damato, Bertil

doi:10.1001/archophthalmol.2012.1677

Cited by 2 publications

(3 citation statements)

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“…Tumor size and ciliary body involvement are 2 evidence-based characteristics suggesting that diffuse iris melanomas may be particularly lethal (1, 2, 14, 18, 19). Often presenting as unilateral glaucoma, these tumors have been diagnosed after enucleation or (more recently) treated with glaucoma stents or tubes (20).…”

Section: Discussionmentioning

confidence: 99%

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Microincision, Aspiration Cutter-Assisted Multifocal Iris Biopsy for Melanoma

Finger

Milman

2016

European Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

“…Biopsy-proven iris melanomas have been found to carry a 10.7% risk for metastasis (1–2–3). Thus a safe method of iris tumor biopsy is needed.…”

Section: Introductionmentioning

confidence: 99%

Microincision, Aspiration Cutter-Assisted Multifocal Iris Biopsy for Melanoma

Finger

Milman

2016

European Journal of Ophthalmology

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“…Biopsy-proven iris melanomas have a 10.7 % risk for metastasis [1][2][3]. Fortunately, suspected iris melanomas and other anterior segment tumors are accessible for biopsy through a relatively safe, clear corneal incisions, offering cytologic, histopathologic, molecular and genetic evaluation [4][5][6][7].…”

Section: клинические исследованияmentioning

confidence: 99%

27-gauge micro incision biopsy technique for tumors of the iris and ciliary body

Scripsema¹,

Finger²

2018

ROJ

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Purpose.To evaluate a 27-gauge aspiration-cutter technique for biopsy of anterior segment neoplasia. Methods. In this retrospective case review, all patients had clinically diagnosed iris or ciliary body tumors. Each underwent surgical iridectomy biopsy utilizing a modification of the Finger Iridectomy Technique (FIT). Specifically, a beveled clear corneal incision was created with a 27-G inked trocar. Sodium hyaluronate 1 % was infused to posteriorly displace the iris and stabilize the chamber. Then a 27-G aspiration-cutter probe was introduced into the anterior chamber, to a position over the tumor. With the aspiration portal abutting the lesion, surgical iridectomy biopsies were obtained using a cut rate of 300 cuts/min and aspiration of 600 mmHg. After each pass, the probe was removed, its tip placed in balanced salt solution and its contents aspirated into a 3-mL syringe. Each syringe was labeled by pass number and tumor location (by clock hour). After obtaining multiple biopsies, the sodium hyaluronate 1 % was removed and the integrity of the wound checked. Main Outcome Measures. Cytologic, tissue histopathology, and immunohistochemical analyses were performed for diagnostic purposes. Visual acuity, intraocular pressure control and procedure-related complications were secondary outcomes measures. Results. Diagnostic specimens were obtained in all 8 cases (100 %). Diagnoses included unifocal melanoma (62 %), diffuse multifocal melanoma (13 %), and melanocytoma (25 %). All 27-gauge corneal wounds were self-sealing. There was no secondary glaucoma, infection, cataract, or vision loss. Two patients had small transient hyphemas which resolved within 10 days. Conclusions. This study reveals that 27-gauge aspiration-cutter assisted surgical iridectomy biopsy was both minimally invasive and effective. It allowed for partial and full-thickness iris biopsy. Compared to larger-gauge aspiration cutter assisted biopsy techniques, this 27-G aspiration-cutter probe allowed for even smaller corneal incisions, rapid recovery and tissue for pathology evaluation.

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Angle Involvement and Glaucoma in Patients With Biopsy-Proven Iris Melanoma: A Response—Reply

Cited by 2 publications

References 5 publications

Microincision, Aspiration Cutter-Assisted Multifocal Iris Biopsy for Melanoma

Microincision, Aspiration Cutter-Assisted Multifocal Iris Biopsy for Melanoma

27-gauge micro incision biopsy technique for tumors of the iris and ciliary body

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