Anhedonia in depression: neurobiological and genetic aspects

Кибитов, А.О.; Мазо, Г. Э.

doi:10.17116/jnevro2021121031146

Cited by 5 publications

(2 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Takagaki et al [ 18 ] found a negative association between the behavioral activation system and depressive symptoms among 18-19 years old college students with depressive symptoms in a Japanese University. Absence of pleasure was a core symptom of depression[ 19 ] which was related to the dysfunction of the brain's DA reward system[ 20 ]. Deficits in the reward system served as a susceptibility factor and predictor of depression, with state independence and heritability[ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation and pathways of behavioral activation systems mediating physical activity level and depressive symptoms among college students

Zhu,

Li,

Wang

et al. 2023

World J Psychiatry

View full text Add to dashboard Cite

BACKGROUND Depression is a common mental disorder among college students. The main symptoms include being persistent low mood, sad emotional experiences, lack of pleasure, listlessness, and impaired cognitive function accompanied by tendencies of self-harm and suicide. AIM To clarify the pathways and effects of the behavioral activation system between physical activity and depressive symptoms in college students with depressive symptoms. METHODS This cross-sectional research screened 3047 college students. Of these, 472 had depressive symptoms, with a depression detection rate of 15.49%. Furthermore, 442 college students with depressive symptoms were analyzed. A one-way analysis of variance and Pearson’s correlation, linear regression, and structural equation modeling analyses were used to explore the correlations and pathways of the interactions between the variables. RESULTS Depressive symptoms were significantly negatively correlated with physical activity (r = -0.175, P < 0.001), the behavioral activation system (r = -0.197, P < 0.001), and drive (r = -0.113, P = 0.017). Furthermore, it was negatively correlated with fun-seeking (FS) (r = -0.055, P = 0.251); however, it was not significant. Physical activity was significantly positively correlated with reward responsiveness (RR) (r = 0.141, P = 0.003) and drive (r = 0.124, P = 0.009) and not significantly positively correlated with FS (r = 0.090, P = 0.058). The mediating effect of RR between physical activity and depressive symptoms was significant [B = -0.025, 95% confidence interval (95%CI): -0.051 to -0.008, P = 0.001]. The direct and total effects of physical activity on depressive symptoms and were significant (B = -0.150, 95%CI: -0.233 to -0.073, P < 0.001; B = -0.175, 95%CI: -0.260 to -0.099, P < 0.001), respectively. CONCLUSION As physical activity levels increased, depression scores among college students decreased. The mediating effect of RR between physical activity and depressive symptoms was significant. Therefore, colleges and universities should encourage college students with depression to increase their physical activity and improve their behavioral activation system. Particular attention should be paid to RR, which may reduce the prevalence of depressive symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation and pathways of behavioral activation systems mediating physical activity level and depressive symptoms among college students

Zhu,

Li,

Wang

et al. 2023

World J Psychiatry

View full text Add to dashboard Cite

show abstract

“…This phenomenon is considered to be a symptom of regulatory disruptions in the brain reward system [ 2 ]. Anhedonia has a transdiagnostic nature and is one of the key symptoms of major depression, bipolar disorder (BD), schizophrenia, and addictions affecting the effectiveness of therapy and the clinical course [ 3 , 4 ]. The role of anhedonia in the risk of suicidal behavior is highlighted, regardless of the severity of major depression [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders

Kasyanov,

Pinakhina,

Rakitko

et al. 2024

Consortium Psychiatricum

View full text Add to dashboard Cite

BACKGROUND: Anhedonia is characterized by a reduced ability to anticipate, experience, and/or learn about pleasure. This phenomenon has a transdiagnostic nature and is one of the key symptoms of mood disorders, schizophrenia, addictions, and somatic conditions. AIM: To evaluate the genetic architecture of anhedonia and its overlap with other mental disorders and somatic conditions. METHODS: We performed a genome-wide association study of anhedonia on a sample of 4,520 individuals from a Russian non-clinical population. Using the available summary statistics, we calculated polygenic risk scores (PRS) to investigate the genetic relationship between anhedonia and other psychiatric or somatic phenotypes. RESULTS: No variants with a genome-wide significant association were identified. PRS for major depression, bipolar disorder, and schizophrenia were significantly associated with anhedonia. Conversely, no significant associations were found between PRS for anxiety and anhedonia, which aligns well with existing clinical evidence. None of the PRS for somatic phenotypes attained a significance level after correction for multiple comparisons. A nominal significance for the anhedonia association was determined for omega-3 fatty acids, type 2 diabetes mellitus, and Crohn’s disease. CONCLUSION: Anhedonia has a complex polygenic architecture, and its presence in somatic diseases or normal conditions may be due to a genetic predisposition to mood disorders or schizophrenia.

show abstract

Anhedonia in mood disorders and somatic diseases: results of exploratory Mendelian randomization analysis

Kasyanov¹,

Pinakhina²,

Rakitko³

et al. 2023

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

Anhedonia in depression: neurobiological and genetic aspects

Cited by 5 publications

References 106 publications

Correlation and pathways of behavioral activation systems mediating physical activity level and depressive symptoms among college students

Correlation and pathways of behavioral activation systems mediating physical activity level and depressive symptoms among college students

Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders

Anhedonia in mood disorders and somatic diseases: results of exploratory Mendelian randomization analysis

Contact Info

Product

Resources

About