Aniline tetramer embedded polyurethane/siloxane membranes and their corresponding nanosilver composites as intelligent wound dressing materials

Abstract

The preparation of functional intelligent wound dressing membranes with features including: excellent dimensional stability in both dry and hydrated states, preserving a moist environment over the wounded area by self-adjustment of their permeability in response to wound moisture level, a broad spectrum of antimicrobial activity towards different microorganisms, promising antioxidant (radical scavenging) efficiency and significant activity for stimulation of fibroblast cells growth and proliferation is reported in this work. For the preparation of dressing membranes, NCO-terminated polyurethane prepolymers and a CHO-terminated aniline tetramer are functionalized with silane groups. Polyurethane/siloxane networks are prepared through a sol-gel reaction of these components at different weight ratios. The corresponding nanosilver composites are simply prepared by a redox reaction through impregnating the membranes with a silver salt solution. Based on various in vitro tests, it is revealed that some of the prepared membranes have the basic characteristics of ideal dressings, while they can actively alleviate the healing of tissue in the wounded area. View Article Onlinea According to analysis of variances P-values of <0.05 were considered signicant. The difference between quantities with similar superscripts is not signicant (p $ 0.05) for data of each column.This journal is

Thermoresponsive antimicrobial wound dressings via simultaneous thiol-ene polymerization and in situ generation of silver nanoparticles

“…Despite a partial decrease in measured gel contents for these samples, the network formation was conducted well in this case. 40 Consumption of free radicals generated in this system by silver ion was responsible for this happening. However, high functional group conversion and appropriate gel content of final networks was indebted to high efficacy of thiol-ene reaction.…”

“…Silver atoms content and their distribution map were measured by 40 EDX analysis using a scanning electron microscope (SEM, Tescan, Vega II, Czech) equipped with an energy dispersive Xray analyzer system ( …”

“…Therefore, using wound dressings is mandatory for the promotion of rapid wound healing with the best functional and cosmetic results. 3 For this purpose, 40 wound dressings should have proper cytocompatibility, appropriate flexibility, gas permeability, durability, and more importantly the ability to manage exudates to prevent scab and scar formation on wounded area. Meanwhile, non-adherence to wound bed and prevention from bacterial/fungal infection of 45 damaged tissues are two key features of versatile modern wound dressings.…”

“…16,17 Therefore, AgNPs based disinfectant was used in this study. Unfortunately, adding preformed AgNPs to dressing membranes is not an easy task and many problems regarding improper loading and dispersion of such nanoparticles may be 40 faced. Finding an easy procedure to overcome this problem was another concern of the present study.…”

Electroactive polyurea/CNT composite-based electrode for detection of vitamin C

“…The multicolor of electroactive polymers could be controlled by changing pH values or the applied potential. Furthermore, a series of electroactive block copolymers with bioactive properties have also been synthesized [16,17]. The conductivity of electroactive polymer could stimulate cell growth, especially in neural or cardiovascular cells, which are sen-sitive to electrical signals.…”