Animal-free strategies in food safety &amp; nutrition: What are we waiting for? Part I: Food safety

Boer, Alie de; Krul, Lisette; Fehr, Markus; Geurts, Lucie; Kramer, Nynke I.; Urbieta, Maria Tabernero; Harst, Johanneke van der; Water, Bob van de; Venema, Koen; Schütte, Katrin; Hepburn, Paul

doi:10.1016/j.tifs.2020.10.034

Cited by 21 publications

(10 citation statements)

References 63 publications

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“…7. Regarding risk assessment (Renwick et al, 2003;Goga and Clementi, 2010;van der Fels-Klerx et al, 2010;Worm et al, 2010;Magnuson et al, 2013;Barlow et al, 2015;Steffensen et al, 2018;Verhoeckx et al, 2020), some authors studied this theme by linking it to different profiles as follows: food safety management (Taylor, 2002;de Boer and Bast, 2018;de Boer et al, 2020;Tomasevic et al, 2020), risk management (Van Kleef et al, 2007Knudsen et al, 2008;Walls et al, 2011), food management (Walls et al, 2011, and safety evaluation in accordance with regulatory requirements (Constable et al, 2007;Magnuson et al, 2013).…”

Section: Vosviewer Discussionmentioning

confidence: 99%

Driving Management of Novel Foods: A Network Analysis Approach

Zarbà

Chinnici

Hamam

et al. 2022

Front. Sustain. Food Syst.

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The food industry has confronted, in recent years, numerous issues including meeting a food demand for individual well-being in a sufficient and healthy manner, also due to the effects of the world population growth. In this scenario, alternative food sources may be a key element both for their contribution to food needs and for the promotion of sustainable and innovative production patterns. These food sources, new compared to traditional food styles, have been regulated by specific European Union regulations under the definition of novel foods. Their importance in the world has raised different topics of scientific research. The present paper aimed to seize the direction of scientific studies in the world focused on the thematic area of novel foods, from a management point of view. This study analyzed 209 papers and carried out a descriptive analysis and a network analysis of the thematic areas under examination also with the help of the software VOSviewer. The results highlighted the importance of scientific research in the world also for the contributions on the exploration of existing markets as well as for the innovative solutions it provides, which aim to expand market possibilities. Finally, the existence of several elements and factors, which may discourage the propensity to consume and therefore the development of the novel foods market, seemed to emerge, and for this reason, many surveys focused on finding solutions to overcome these potential obstacles.

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Section: Vosviewer Discussionmentioning

confidence: 99%

Driving Management of Novel Foods: A Network Analysis Approach

Zarbà

Chinnici

Hamam

et al. 2022

Front. Sustain. Food Syst.

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“…The general food law (GFL), the European framework regulation on foods, has the purpose to assure the maximum protection level of human health and consumer interest while certifying the correct functioning of the internal European market for both food and feed. Furthermore, the GFL is also the founding regulation for EFSA to provide scientific advice and technical support for all European legislation and policies regarding the food and feed safety matters [ 45 ].…”

Section: Food Waste Bioactive Compounds Regulatory and Legislative Issuesmentioning

confidence: 99%

“…However, they can still reject the proposal if does not comply with the EU legislation conditions [ 51 ]. The European regulatory framework considers that functional foods must match the general food laws [ 45 ].…”

Section: Food Waste Bioactive Compounds Regulatory and Legislative Issuesmentioning

confidence: 99%

Natural Bioactive Compounds from Food Waste: Toxicity and Safety Concerns

Vilas-Boas

Pintado

Oliveira

2021

Foods

106

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Although synthetic bioactive compounds are approved in many countries for food applications, they are becoming less and less welcome by consumers. Therefore, there has been an increasing interest in replacing these synthetic compounds by natural bioactive compounds. These natural compounds can be used as food additives to maintain the food quality, food safety and appeal, and as food supplements or nutraceuticals to correct nutritional deficiencies, maintain a suitable intake of nutrients, or to support physiological functions, respectively. Recent studies reveal that numerous food wastes, particularly fruit and vegetables byproducts, are a good source of bioactive compounds that can be extracted and reintroduced into the food chain as natural food additives or in food matrices for obtaining nutraceuticals and functional foods. This review addresses general questions concerning the use of fruit and vegetables byproducts as new sources of natural bioactive compounds that are being addressed to foods as natural additives and supplements. Those bioactive compounds must follow the legal requirements and evaluations to assess the risks for human health and their toxicity must be considered before being launched into the market. To overcome the potential health risk while increasing the biological activity, stability and biodistribution of the supplements’ technological alternatives have been studied such as encapsulation of bioactive compounds into micro or nanoparticles or nanoemulsions. This will allow enhancing the stability and release along the gastrointestinal tract in a controlled manner into the specific tissues. This review summarizes the valorization path that a bioactive compound recovered from an agro-food waste can face from the moment their potentialities are exhibited until it reaches the final consumer and the safety and toxicity challenges, they may overcome.

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“…In vivo liver- and gastrointestinal tract-specific MN protocols have been evaluated and validated in rodents (Uno et al 2015 ; Kirkland et al 2019 ); tissues/animals are exposed repeatedly over a 2/4-week period to ensure that sufficient cell proliferation has occurred (Hamada et al 2015 ; Martus et al 2015 ). However, the use of animal studies is also facing higher scrutiny nowadays with many companies and regulators moving away from in vivo testing requirements when valid non-animal alternatives exist (Boer et al 2020 ; Hardy et al 2018 ; Xavier et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances

et al. 2022

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The micronucleus (MN) assay is widely used as part of a battery of tests applied to evaluate the genotoxic potential of chemicals, including new food additives and novel food ingredients. Micronucleus assays typically utilise homogenous in vitro cell lines which poorly recapitulate the physiology, biochemistry and genomic events in the gut, the site of first contact for ingested materials. Here we have adapted and validated the MN endpoint assay protocol for use with complex 3D reconstructed intestinal microtissues; we have named this new protocol the reconstructed intestine micronucleus cytome (RICyt) assay. Our data suggest the commercial 3D microtissues replicate the physiological, biochemical and genomic responses of native human small intestine to exogenous compounds. Tissues were shown to maintain log-phase proliferation throughout the period of exposure and expressed low background MN. Analysis using the RICyt assay protocol revealed the presence of diverse cell types and nuclear anomalies (cytome) in addition to MN, indicating evidence for comprehensive DNA damage and mode(s) of cell death reported by the assay. The assay correctly identified and discriminated direct-acting clastogen, aneugen and clastogen requiring exogenous metabolic activation, and a non-genotoxic chemical. We are confident that the genotoxic response in the 3D microtissues more closely resembles the native tissues due to the inherent tissue architecture, surface area, barrier effects and tissue matrix interactions. This proof-of-concept study highlights the RICyt MN cytome assay in 3D reconstructed intestinal microtissues is a promising tool for applications in predictive toxicology.

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Animal-free strategies in food safety & nutrition: What are we waiting for? Part I: Food safety

Cited by 21 publications

References 63 publications

Driving Management of Novel Foods: A Network Analysis Approach

Driving Management of Novel Foods: A Network Analysis Approach

Natural Bioactive Compounds from Food Waste: Toxicity and Safety Concerns

Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances

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