Animal Models of Bone Diseases-A

Kan, Lixin

doi:10.1016/b978-0-12-415894-8.00016-6

Cited by 3 publications

(2 citation statements)

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“…Mice models are popular in studies of skeletal physiology due to their relatively low cost, high rates of reproduction, and ease of handling and care ( 5 ). They also provide the opportunity to collect phenotype data not available from humans, and to study the effect of single, specific interventions that are not possible in patients such as changes to diet, age, or genetics ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

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Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

et al. 2021

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A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

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Section: Introductionmentioning

confidence: 99%

“…A number of features of bone biology are shared between the mouse and human skeleton. Like humans, mice experience age-related bone loss ( 5 ). They also undergo similar patterns of bone turnover and bone healing to humans ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

et al. 2021

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Inducible Models of Bone Loss

Doucette

Rosen

2014

CP Mouse Biology

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Bone is an essential organ that not only confers structural stability to the organism, but also serves as a reservoir for hematopoietic elements and is thought to affect systemic homeostasis through the release of endocrine factors as well as calcium. The loss of bone mass due to an uncoupling of bone formation and bone resorption leads to increased fragility that can result in devastating fractures. Further understanding of the effects of environmental stimuli on the development of bone disease in humans is needed, and can be studied using animal models. In this chapter, we present established and novel methods for the induction of bone loss in mice, including manipulation of diet and environment, drug administration, irradiation, and hormone deficiency. All of these models are directly related to human cases, and can thus be used to investigate the causes of bone loss resulting from these interventions.

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Bone Physiology and Biology

Gasser

Kneissel

2017

Molecular and Integrative Toxicology

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Animal Models of Bone Diseases-A

Cited by 3 publications

References 278 publications

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Inducible Models of Bone Loss

Bone Physiology and Biology

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