Animal models of radiation retinopathy – From teletherapy to brachytherapy

Ramos, Michael; Echegaray, Jose J.; Kuhn-Asif, Sonia; Wilkinson, Allan; Yuan, Alex; Singh, Arun D.; Browne, Andrew

doi:10.1016/j.exer.2019.01.019

Cited by 15 publications

(11 citation statements)

References 93 publications

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“…RR animal model studies performed using capuchin monkey eyes irradiated with an external beam, and the first change detected around 10 months post-irradiation was the focal loss of endothelial cells and pericytes, yielding acellular capillaries ( Irvine and Wood 1987 ; Ramos et al, 2019 ). Later, Hiroshiba et al demonstrated that irradiation reduced the leukocyte velocity in capillaries and gradually increased leukocyte entrapment in the retinal microcirculation ( Hiroshiba et al, 1999 ).…”

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy has been used to treat malignancies involving the globe, orbit, head, and neck, and radiotherapy usually causes several secondary complications, including radiation keratopathy, radiation iris neovascularization, neovascular glaucoma, radiation cataracts, radiation optic neuropathy, and radiation retinopathy (RR) ( Reichstein 2015 ; Rose et al, 2018 ; Ramos et al, 2019 ). Among them, RR is characterized by progressive ischemic and proliferative changes that are similar to the development of diabetic retinopathy and can lead to irreversible loss of visual function ( Rose et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Human Umbilical Cord Blood-Derived CD133+CD34+ Cells Protect Retinal Endothelial Cells and Ganglion Cells in X-Irradiated Rats through Angioprotective and Neurotrophic Factors

Chen

Sun

et al. 2022

Front. Cell Dev. Biol.

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Radiation retinopathy (RR) is a common complication following radiation therapy of globe, head, and neck malignancies, and is characterized by microangiopathy, neuroretinopathy, and the irreversible loss of visual function. To date, there is no effective treatment for RR. Stem cells have been clinically used to treat retinal degeneration. CD133+CD34+ cells from human umbilical cord blood (hUCB-CD133+CD34+ cells), a subpopulation of hematopoietic stem cells, were applied to determine their protective efficacy on irradiated rat retinas. After X-ray irradiation on the retinas, rats were intravitreally injected with hUCB-CD133+CD34+ cells. Transplantation of hUCB-CD133+CD34+ cells prevented retinal dysfunction 2 weeks post-operation and lasted at least 8 weeks. CD133+CD34+ cells were distributed along the retinal vessel and migrated to the ganglion cell layer. Moreover, grafted CD133+CD34+ cells reduced the apoptosis of endothelial and ganglion cells in irradiated rats and increased the number of survived CD31+ retinal endothelial cells and Brn3a+ ganglion cells at 2 and 4 weeks, respectively, post-operation. Co-culturing of CD133+CD34+ cells or supernatants with irradiated human retinal microvascular endothelial cells (hRECs) in vitro, confirmed that CD133+CD34+ cells ameliorated hREC apoptosis caused by irradiation. Mechanistically, we found that angioprotective mediators and neurotrophic factors were secreted by CD133+CD34+ cells, which might attenuate irradiation-induced injury of retinal endothelial cells and ganglion cells. hUCB-CD133+CD34+ cell transplantation, as a novel treatment, protects retinal endothelial and ganglion cells of X-irradiated rat retinas, possibly through angioprotective and neurotrophic factors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human Umbilical Cord Blood-Derived CD133+CD34+ Cells Protect Retinal Endothelial Cells and Ganglion Cells in X-Irradiated Rats through Angioprotective and Neurotrophic Factors

Chen

Sun

et al. 2022

Front. Cell Dev. Biol.

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“…[ 9 ] Combinations of both systemic and external beam radiotherapies for CM previously showed lower regrowth rates, [ 10 , 11 ] but therapies targeting driver mutations spare patients from ophthalmic adverse reactions to therapy, including radiation keratopathy, iris neovascularization and glaucoma, accelerated cataract formation, and optic neuropathy. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Treatment of Choroidal Metastasis from Epidermal Growth Factor Mutant Non-Small Cell Lung Cancer with First-line Osimertinib Therapy

Mehta

Israelsen

et al. 2022

JOVR

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Purpose: To illustrate the regression of a metastatic lesion through ophthalmic imaging and correlating findings with standard chest imaging and treatment with osimertinib, an oral chemotherapy agent specific to Epidermal Growth Factor Receptor + Non-small Cell Lung Cancer (EGFR+ NSCLC). Case Report: A 63-year-old Asian male presented to ophthalmology with a complaint of left blurry vision. Initial ophthalmic exam revealed a choroidal lesion and imaging results highlighted a spiculated lung mass with brain and bony metastases. Osimertinib was chosen for its specificity and ability to cross the blood–brain barrier. Follow-up ophthalmic and radiographic imaging were repeated over the course of treatment. Conclusion: After the initiation of osimertinib, ophthalmic and computed tomography imaging highlighted the regression of the ocular metastatic disease and primary malignancy, respectively. Osimertinib is an effective first-line treatment of EGFR+ NSCLC and corresponding metastatic sites. Additionally, ophthalmic imaging can be used to monitor general response to chemotherapy agents when ocular metastasis is identified.

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“…Radyasyon etkisinin şiddetini belirleyen faktörler; radyoaktif kaynağın cinsi (kobalt, iyot, palladyum, ruthenyum,..), açığa çıkan ışınımın cinsi (X Ray, gamma, beta, proton, elektron,..), total ışınım miktarı (doz), ışınımın etki alanı (ışına maruz kalan alan), uygulama sıklığı (tek sefer, çoğul tedavi), ışına maruz kalınan süredir. [4][5][6][7][8][9] Gama ve X ışınları dokularda iyonizasyona neden olur. Görülebilir ışık ve ultraviolet ışınları canlı hücrelerin floresan bir molekülle aydınlatıldığında oksijen radikalleri oluşumu ile dış kan retina bariyerini bozarak fotoreseptörlerde ve retina pigment epitelinde fotokimyasal retinotoksisiteye neden olur.…”

Section: Introductionunclassified

Electromagnetic, Ultrasonic, Photic and Electrical Posterior Segment Ocular Traumas

2022

Güncel Retina (Current Retina)

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Electromagnetic, ultrasonic, photonic, and electrical external factors can damage the sensitive posterior segment structures of the eye. After trauma, patients can apply to eye clinics with vision loss. Electromagnetic, ultrasonic, photic, and electrical traumas can damage the retina through mechanical, thermal, and chemical effects. The most important complaints of patients who are referred to the eye clinics are decreased visual acuity and visual field loss. Trauma history should be carefully questioned in patients presenting with these complaints. When patients have a history of electromagnetic, ultrasonic, photic, and electrical trauma, it is important to perform detailed retinal and posterior segment examination and evaluation.

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Animal models of radiation retinopathy – From teletherapy to brachytherapy

Cited by 15 publications

References 93 publications

Human Umbilical Cord Blood-Derived CD133+CD34+ Cells Protect Retinal Endothelial Cells and Ganglion Cells in X-Irradiated Rats through Angioprotective and Neurotrophic Factors

Human Umbilical Cord Blood-Derived CD133+CD34+ Cells Protect Retinal Endothelial Cells and Ganglion Cells in X-Irradiated Rats through Angioprotective and Neurotrophic Factors

Treatment of Choroidal Metastasis from Epidermal Growth Factor Mutant Non-Small Cell Lung Cancer with First-line Osimertinib Therapy

Electromagnetic, Ultrasonic, Photic and Electrical Posterior Segment Ocular Traumas

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