Animal models of vertical bone augmentation (Review)

Zhang, Zepeng; Gan, Yaxin; Guo, Yimin; Lu, Xuesong; Li, Xianqi

doi:10.3892/etm.2021.10351

Cited by 7 publications

(9 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Grafting material Composite grafts ABBM + AB. 72,[78][79][80][81][82][83][84][85] AB harvested from intra-oral sources 78,[81][82][83][84][85] or from extra-oral sources (iliac crest) 79,80 Pure grafts:…”

Section: D-printed Titanium Mesh Personalized Devicesmentioning

confidence: 99%

“…Type-1 & -3 non-cross-linked collagen 79,82,83,87,88 & type-1 cross-linked collagen 85 Cross linked type-1 collagen improved bone regeneration 85 Regenerative outcomes Linear vertical gain (2.5-6.5mm) and horizontal gain (2.57-6.35mm) 72,79,83 Regenerated fraction 88% for smaller 81 and larger defects 78 Common complications Wound dehiscence 7.7%-66.6% [77][78][79][80][81][82][83]85 Dehiscence consequences:…”

Section: Membranesmentioning

confidence: 99%

“…• Mostly conservative management and no change to timing of scaffold removal 80,83,85 • Some resulted in scaffold infection, premature removal 78,83 , and reduction in regenerative fraction 78,83,85 Other complications Altered sensation-1/10 patients 81 Abbreviations: AB; autogenous bone; ABBM, anorganic bovine bone mineral; PRF, platelet-rich fibrin.…”

Section: Membranesmentioning

confidence: 99%

“…72,[79][80][81][82][83][84][85] Histomorphometry Lamellar bone 35.8%, woven bone 16.4%, osteoid 10.8%, residual graft particles 14%, and soft tissue 22.7%84 Biologicals PRF (membrane + liquid)79,81,82,87,88 PRF membrane significantly reduced wound dehiscence82 …”

mentioning

confidence: 99%

See 3 more Smart Citations

3D printing for bone regeneration: challenges and opportunities for achieving predictability

Ivanovski,

Breik,

Carluccio

et al. 2023

Periodontology 2000

View full text Add to dashboard Cite

Abstract3D printing offers attractive opportunities for large‐volume bone regeneration in the oro‐dental and craniofacial regions. This is enabled by the development of CAD‐CAM technologies that support the design and manufacturing of anatomically accurate meshes and scaffolds. This review describes the main 3D‐printing technologies utilized for the fabrication of these patient‐matched devices, and reports on their pre‐clinical and clinical performance including the occurrence of complications for vertical bone augmentation and craniofacial applications. Furthermore, the regulatory pathway for approval of these devices is discussed, highlighting the main hurdles and obstacles. Finally, the review elaborates on a variety of strategies for increasing bone regeneration capacity and explores the future of 4D bioprinting and biodegradable metal 3D printing.

show abstract

Section: D-printed Titanium Mesh Personalized Devicesmentioning

confidence: 99%

Section: Membranesmentioning

confidence: 99%

Section: Membranesmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

3D printing for bone regeneration: challenges and opportunities for achieving predictability

Ivanovski,

Breik,

Carluccio

et al. 2023

Periodontology 2000

View full text Add to dashboard Cite

show abstract

“…However, a major challenge to successful implant therapy is overcoming unfavorable host conditions including insufficient width and height of innate bone to receive an implant [32][33][34][35][36][37][38][39][40]. To achieve this, the execution and outcome of vertical bone augmentation require significant improvement [32,[41][42][43][44][45][46][47][48][49][50][51].…”

Section: Of 18mentioning

confidence: 99%

Ultraviolet Light Treatment of Titanium Microfiber Scaffolds Enhances Osteoblast Recruitment and Osteoconductivity in a Vertical Bone Augmentation Model: 3D UV Photofunctionalization

Kitajima

Hirota

Komatsu

et al. 2022

Cells

View full text Add to dashboard Cite

Vertical bone augmentation to create host bone prior to implant placement is one of the most challenging regenerative procedures. The objective of this study is to evaluate the capacity of a UV-photofunctionalized titanium microfiber scaffold to recruit osteoblasts, generate intra-scaffold bone, and integrate with host bone in a vertical augmentation model with unidirectional, limited blood supply. Scaffolds were fabricated by molding and sintering grade 1 commercially pure titanium microfibers (20 μm diameter) and treated with UVC light (200–280 nm wavelength) emitted from a low-pressure mercury lamp for 20 min immediately before experiments. The scaffolds had an even and dense fiber network with 87% porosity and 20–50 mm inter-fiber distance. Surface carbon reduced from 30% on untreated scaffold to 10% after UV treatment, which corresponded to hydro-repellent to superhydrophilic conversion. Vertical infiltration testing revealed that UV-treated scaffolds absorbed 4-, 14-, and 15-times more blood, water, and glycerol than untreated scaffolds, respectively. In vitro, four-times more osteoblasts attached to UV-treated scaffolds than untreated scaffolds three hours after seeding. On day 2, there were 70% more osteoblasts on UV-treated scaffolds. Fluorescent microscopy visualized confluent osteoblasts on UV-treated microfibers two days after seeding but sparse and separated cells on untreated microfibers. Alkaline phosphatase activity and osteocalcin gene expression were significantly greater in osteoblasts grown on UV-treated microfiber scaffolds. In an in vivo model of vertical augmentation on rat femoral cortical bone, the interfacial strength between innate cortical bone and UV-treated microfiber scaffold after two weeks of healing was double that observed between bone and untreated scaffold. Morphological and chemical analysis confirmed seamless integration of the innate cortical and regenerated bone within microfiber networks for UV-treated scaffolds. These results indicate synergy between titanium microfiber scaffolds and UV photofunctionalization to provide a novel and effective strategy for vertical bone augmentation.

show abstract

Dextrin hydrogel loaded with a macroporous Bonelike® scaffold and dental pulp stem cells for critical-sized defect repair

Machado

Pereira

et al. 2023

Materialia

View full text Add to dashboard Cite

Animal models of vertical bone augmentation (Review)

Cited by 7 publications

References 98 publications

3D printing for bone regeneration: challenges and opportunities for achieving predictability

3D printing for bone regeneration: challenges and opportunities for achieving predictability

Ultraviolet Light Treatment of Titanium Microfiber Scaffolds Enhances Osteoblast Recruitment and Osteoconductivity in a Vertical Bone Augmentation Model: 3D UV Photofunctionalization

Dextrin hydrogel loaded with a macroporous Bonelike® scaffold and dental pulp stem cells for critical-sized defect repair

Contact Info

Product

Resources

About