Animal Models of Zika Virus Infection, Pathogenesis, and Immunity

Morrison, Thomas E.; Diamond, Michael S.

doi:10.1128/jvi.00009-17

Cited by 241 publications

(254 citation statements)

References 114 publications

(166 reference statements)

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“…ZIKV-associated neuronal dysfunction may develop postnatally, and there remains a lack of understanding of the long-term cognitive and physical disabilities associated with cZVS (41). Many models of ZIKV infection have been established but none have or can systematically examine the consequences of viral infection across pre-and postnatal brain development (16,30,42).…”

Section: Discussionmentioning

confidence: 99%

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Replication of early and recent Zika virus isolates throughout mouse brain development

Rosenfeld

Doobin

Warren

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Fetal infection with Zika virus (ZIKV) can lead to congenital Zika virus syndrome (cZVS), which includes cortical malformations and microcephaly. The aspects of cortical development that are affected during virus infection are unknown. Using organotypic brain slice cultures generated from embryonic mice of various ages, sites of ZIKV replication including the neocortical proliferative zone and radial columns, as well as the developing midbrain, were identified. The infected radial units are surrounded by uninfected cells undergoing apoptosis, suggesting that programmed cell death may limit viral dissemination in the brain and may constrain virus-associated injury. Therefore, a critical aspect of ZIKV-induced neuropathology may be defined by death of uninfected cells. All ZIKV isolates assayed replicated efficiently in early and midgestation cultures, and two isolates examined replicated in late-gestation tissue. Alteration of neocortical cytoarchitecture, such as disruption of the highly elongated basal processes of the radial glial progenitor cells and impairment of postmitotic neuronal migration, were also observed. These data suggest that all lineages of ZIKV tested are neurotropic, and that ZIKV infection interferes with multiple aspects of neurodevelopment that contribute to the complexity of cZVS.

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Section: Discussionmentioning

confidence: 99%

“…Several animal models of ZIKV infection, including mice and nonhuman primates, have recently been established (16). These models illustrate many features of ZIKV-induced pathology, including viremia and neuronal tissue tropism.…”

mentioning

confidence: 99%

Replication of early and recent Zika virus isolates throughout mouse brain development

Rosenfeld

Doobin

Warren

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…In preclinical work aimed at developing such therapies, researchers have developed several mouse models of ZIKV infection, many of which require overcoming the natural murine immune resistance to ZIKV [4]. In the model our research team has used pregnant mice lacking an interferon receptor subcutaneously injected with ZIKV.…”

Section: Animal Models Of Zikv Infection In Pregnancymentioning

confidence: 99%

To Zika and Destroy: An Antimalarial Drug Protects Fetuses from Zika Infection

2018

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“…Number of animal models have been established to study the efficacy of novel therapeutics as well as mechanisms behind pathogenesis, dissemination, host immune responses to ZIKV in developing fetuses, pregnant mothers, and adults [62] . ZIKV strain (MR 766, Uganda 1947) has been passaged serially in brains of mice for 64 more than 100 times [63] .…”

Section: Animal Modelsmentioning

confidence: 99%

Advances in research on Zika virus

Ali

Wahid

Rafique

et al. 2017

Asian Pacific Journal of Tropical Medicine

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Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV started with a first outbreak in the Pacific area in 2007, a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands. Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine. Several vaccine platforms such as DNA vaccine, recombinant subunit vaccine, ZIKV purified inactivated vaccine, and chimeric vaccines have shown potent efficacy in vitro and in vivo trials. Moreover, number of drugs such as Sofosbuvir, BCX4450, NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity. Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women. In this review, we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines, molecular evolution, epidemiology emergence, neurological complications and other teratogenic outcomes as well as pathogenesis.

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Animal Models of Zika Virus Infection, Pathogenesis, and Immunity

Cited by 241 publications

References 114 publications

Replication of early and recent Zika virus isolates throughout mouse brain development

Replication of early and recent Zika virus isolates throughout mouse brain development

To Zika and Destroy: An Antimalarial Drug Protects Fetuses from Zika Infection

Advances in research on Zika virus

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