2017
DOI: 10.1111/aej.12221
|View full text |Cite
|
Sign up to set email alerts
|

Animal models used in furcation perforation studies: A systematic review and comprehensive synthesis of model characteristics

Abstract: In order to systematise furcation perforation (FP) experimental animal models described in the literature and to determine whether there is evidence that a model is superior to others, MEDLINE/PubMed, SciELO and Cochrane Library were searched to find studies which used animal models of FP. Data were gathered concerning model characteristics, chosen groups, sample numbers, type of outcomes, journal and main area studied. Twenty-five articles were included in this systematic review, four conducted in rodent mode… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
14
0
1

Year Published

2019
2019
2024
2024

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(15 citation statements)
references
References 31 publications
0
14
0
1
Order By: Relevance
“…Several promising materials have emerged for the repair of furcation perforations (Cardoso et al ). The ideal material should provide an adequate seal, be biocompatible, not be affected by blood contamination, be radiopaque, induce mineralization and be easily handled and inserted (Aggarwal et al ).…”
Section: Introductionmentioning
confidence: 99%
“…Several promising materials have emerged for the repair of furcation perforations (Cardoso et al ). The ideal material should provide an adequate seal, be biocompatible, not be affected by blood contamination, be radiopaque, induce mineralization and be easily handled and inserted (Aggarwal et al ).…”
Section: Introductionmentioning
confidence: 99%
“…The material used in direct contact with living tissue should meet certain standards of tissue compatibility, in addition to any therapeutic or mechanical benefit that it may provide. Therefore, this study was conducted to investigate the tissue response to different repairing materials and techniques used in repairing furcation perforations and dogs appear to possess the most suitable model characteristic to furcation perforation studies ( 17 ).…”
Section: Discussionmentioning
confidence: 99%
“…A furcal perforation is defined as a pathologic or mechanical communication between the root canal system and the external tooth surface in the interradicular region of multirooted teeth (American Association of Endodontists, 2020; Cardoso et al, 2018a). Accidental perforations have been reported to account for up to 29% of all iatrogenic errors during root canal treatment (Vehkalahti & Swanljung, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…Although randomized clinical trials are the reference standard for the comparison of materials and methods, few observational studies (de Chevigny et al, 2008; Farzaneh et al, 2004; Gorni et al, 2016; Gorni & Gagliani, 2004; Mente et al, 2010; Ng et al, 2011) and no randomized clinical trials have investigated root canal perforations, because of ethical issues and difficulties in standardizing procedural accidents. Therefore, experimental in vivo models, which may simulate the periradicular tissues and clinical conditions, are widely used to evaluate the biocompatibility and bioactivity of repair materials (Cardoso et al, 2018a). These studies use standardized methods (Hooijmans & Ritskes‐Hoitinga, 2013), which favours comparison between materials and reduces the risk of bias (RoB).…”
Section: Introductionmentioning
confidence: 99%