Animals in Ophthalmic Research: Concepts and Methodologies

Peiffer, Robert L.; Armstrong, Joseph R.; Johnson, Philip T.

doi:10.1016/b978-0-12-278006-6.50008-2

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1983

2005

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References 332 publications

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“…Inflammation in the area of the vitreous body is unlikely to produce corneal lesions, however, and posterior uveitis in MRL/l mice was not considered to be associated with band keratopathy. Nevertheless, our observation of choroid inflammation in the MRL/l substrain was important because this abnormality does not occur spontaneously in other animal models (19). In humans, idiopathic posterior uveitis may lead to disability and loss of vision (20).…”

Section: Discussionmentioning

confidence: 99%

Band Keratopathy in MRL/1 and MRL/n Mice

Hoffman

Yang

Waggie

et al. 1983

Arthritis & Rheumatism

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To define ocular abnormalities in mice with autoimmune disease, we performed biomicroscopic examinations and examined ocular tissue in MRL/1, MRL/n, NZB, NZB/NZW, and Palmerston North mice. Results were compared with MRL/Mp‐Ipr/lpr, C57BL/6J‐lpr/lpr, and normal control strains. Eighty‐seven percent of MRL/1 and MRL/n mice had typical band keratopathy; this was confirmed by histologic examination. Posterior uveitis was found in 35% of adult MRL/l mice. MRL substrains are potentially important models of ocular disease.

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Section: Discussionmentioning

confidence: 99%