Anionic magnetite nanoparticle conjugated with pyrrolidinyl peptide nucleic acid for DNA base discrimination

Multiresponsive Poly(N-Acryloyl glycine)-Based Nanocomposite and Its Drug Release Characteristics

“…Formation of nanocomposite containing multiparticles of MNP embedded in polymer matrix was another promising approach to enhance magnetic sensitivity while maintaining its good dispersibility in the media. When individual unique properties of both MNP and polymer matrix were combined, multifunctional nanocomposite serving as a platform for further conjugation with desirable bioentities can be obtained [16,17]. Thus, this hybrid nanocomposite has been particularly used in the biological field such as drug delivery system [18,19], controlled release [16,20,21], and magnetic separation [11][12][13].…”

“…Thus, this hybrid nanocomposite has been particularly used in the biological field such as drug delivery system [18,19], controlled release [16,20,21], and magnetic separation [11][12][13]. Previous works have reported the synthesis of MNP-polymer nanocomposite having both good magnetic separation ability and good water dispersibility for drug controlled release [4,16] and for conjugation with bioentities [17,22].…”

Superparamagnetic iron oxide nanoparticles functionalized by peptide nucleic acids

“…Very few studies appeared in the literature on the binding of PNA to magnetic iron oxide nanoparticles. 8,9 In the most recent report 9 the covalent binding was obtained by a multistep procedure, involving functionalization of the surface of naked magnetite nanoparticles with 3-aminopropyltriethoxysilane, followed by reaction with acryloyl chloride, to give acrylamide-graed SPION, radical polymerization and further covalent functionalization of the polymer coating with streptavidin. Pyrrolidinyl PNA previously functionalized with biotin was nally conjugated to the nanoparticles, via specic biotin-streptavidin interaction.…”

Amino-containing polymer-coated magnetite nanoparticles as nano-adsorbents for bisphenol A: Synthesis, kinetic and thermodynamic study

“…Recently, magnetic nanoparticles, especially magnetite nanoparticles (MNPs), have gained great amount of attention for potential uses in many applications, such as enzyme and protein immobilization [20], ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) purification [21,22], and metal pre-concentration [23] and separation [24]. The suitability of MNPs for these task is attributed to their large surface area-to-volume ratio [25], good magnetic responsiveness [26], and ease in surface modification [27][28][29]. However, MNPs without surface stabilization tend to agglomerate when dispersed in liquid media due to inter-particle attractive forces, e.g., dipole-dipole interaction and magnetic force.…”