Anisotropic magnetic hydrogels: design, structure and mechanical properties

Gila-Vilchez, Cristina; Mañas‐Torres, Mari C.; Contreras‐Montoya, Rafael; Alaminos, Miguel; Durán, J.D.G.; Cienfuegos, Luı́s Álvarez de; López–López, Modesto T.

doi:10.1098/rsta.2018.0217

Cited by 29 publications

(29 citation statements)

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“…Alternatively, the use of a thick shell coating the nanoparticles was confirmed to hamper the gelation process, with the additional cost of requiring a larger concentration of hydrogelator to compensate for the bulkier nanocomposite [ 10 ]. On the other hand, forcing the supramolecular design strategies to conjugate the nanoparticles with the hydrogelator molecules has also been considered [ 25 , 26 , 27 ]. In general, these existing strategies for supramolecular magnetogels either imply complex fabrication steps and/or fail on the homogeneous incorporation of high concentrations of magnetic material and target drugs, which strongly limit their usability in theranostics.…”

Section: Introductionmentioning

confidence: 99%

Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release

et al. 2020

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Currently, the nanoparticle functionalization effect on supramolecular peptide-based hydrogels remains undescribed, but is expected to affect the hydrogels’ self-assembly and final magnetic gel properties. Herein, two different functionalized nanoparticles: citrate-stabilized (14.4 ± 2.6 nm) and lipid-coated (8.9 ± 2.1 nm) magnetic nanoparticles, were used for the formation of dehydropeptide-based supramolecular magnetogels consisting of the ultra-short hydrogelator Cbz-L-Met-Z-ΔPhe-OH, with an assessment of their effect over gel properties. The lipid-coated nanoparticles were distributed along the hydrogel fibers, while citrate-stabilized nanoparticles were aggregated upon gelation, which resulted into a heating efficiency improvement and decrease, respectively. Further, the lipid-coated nanoparticles did not affect drug encapsulation and displayed improved drug release reproducibility compared to citrate-stabilized nanoparticles, despite the latter attaining a stronger AMF-trigger. This report points out that adsorption of nanoparticles to hydrogel fibers, which display domains that improve or do not affect drug encapsulation, can be explored as a means to optimize the development of supramolecular magnetogels to advance theranostic applications.

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Section: Introductionmentioning

confidence: 99%

Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release

et al. 2020

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“…The same group have also generated anisotropic magnetic hydrogels based on fibrin and alginate, with elastic moduli more than an order of magnitude greater than those of non-magnetic hydrogels. 77,78 Results have shown that the presence of functionalized MNP does not compromise the ex vivo and in vivo biocompatibility. 10,14,19 However, given the technical difficulty in obtaining these types of materials, especially through procedures that provide biocompatibility and scalability, the number of studies to date is very limited.…”

Section: Anisotropic Hydrogelsmentioning

confidence: 99%

Biomedical applications of magnetic hydrogels

Mañas‐Torres

Gila-Vilchez

Durán

et al. 2021

Magnetic Nanoparticle-Based Hybrid Materials

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Hydrogels are used in biomedical applications thanks to their high-water content, porosity, and their ability to easily modify their properties (mechanical, chemical, microstructure, etc.). Hydrogels are the materials that most resemble the extracellular matrix of mammals. In recent years, magnetic hydrogels have become especially important. These are the result of combining magnetic nanoparticles with different hydrogel matrices. Among its properties, they have the ability to be remotely controlled modifying their physical properties, such as stability, stiffness and temperature (magnetic hyperthermia). Such unique characteristics make magnetic hydrogels very promising in biomedical applications such as, tissue engineering, drug delivery, biosensors, and cancer therapy. At this respect, this chapter focuses on the main biomedical applications of magnetic hydrogels and the most important discoveries on the subject.

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“…Magnetic scaffolds are indeed reported to induce tissue damages repair through diverse approaches depending on the kind of tissue to be repaired. For instance, it is possible to design anisotropic magnetic scaffold able to mimic the specific tissue microenvironment for the repair of soft tissue containing hierarchically organized structures [ 126 ]. Most soft biological tissues consist of an extracellular matrix that can be considered a fibrous polymer network containing highly organized nanocomposite structures.…”

Section: Magnetic Scaffolds For Soft Tissue Regeneration Applicatimentioning

confidence: 99%

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

et al. 2020

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The burst of research papers focused on the tissue engineering and regeneration recorded in the last years is justified by the increased skills in the synthesis of nanostructures able to confer peculiar biological and mechanical features to the matrix where they are dispersed. Inorganic, organic and hybrid nanostructures are proposed in the literature depending on the characteristic that has to be tuned and on the effect that has to be induced. In the field of the inorganic nanoparticles used for decorating the bio-scaffolds, the most recent contributions about the paramagnetic and superparamagnetic nanoparticles use was evaluated in the present contribution. The intrinsic properties of the paramagnetic nanoparticles, the possibility to be triggered by the simple application of an external magnetic field, their biocompatibility and the easiness of the synthetic procedures for obtaining them proposed these nanostructures as ideal candidates for positively enhancing the tissue regeneration. Herein, we divided the discussion into two macro-topics: the use of magnetic nanoparticles in scaffolds used for hard tissue engineering for soft tissue regeneration.

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Anisotropic magnetic hydrogels: design, structure and mechanical properties

Abstract: One contribution of 17 to a theme issue 'Heterogeneous materials: metastable and non-ergodic internal structures'.

Cited by 29 publications

References 50 publications

Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release

Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release

Biomedical applications of magnetic hydrogels

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

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