Anisotropic magnetized tubular microrobots for bioinspired adaptive locomotion

Yan, Guanghui; Xu, Borui; Shi, Xiaojie; Zong, Yang; Wu, Yin; Liu, Jinrun; Ouyang, Yi; Chen, Guoxiang; Cui, Jizhai; Mei, Yongfeng

doi:10.1016/j.apmt.2022.101457

Cited by 11 publications

(8 citation statements)

References 48 publications

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“…(Surface‐assisted) Adapted with permission from ref. [55] Copyright 2022, Elsevier Ltd. (B‐b) Adapted with permission from ref. [60] Copyright 2023, The Author(s), under exclusive license to Springer Nature Limited.…”

Section: Nano/micromotorsmentioning

confidence: 99%

Nano/Micromotor‐Driven SERS for Highly Sensitive and Spatially Controlled Sensing

Becerril‐Castro,

Salgueiriño,

Correa‐Duarte

et al. 2023

Adv Funct Materials

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Nano/micromotors (NMs) are tiny structures capable of converting various forms of energy into mechanical motion at the micro and nanoscale. These motors operate in environments characterized by low inertia and low Reynolds numbers. The potential applications of NMs are vast, particularly in the fields of biomedicine and environmental science. One of the most intriguing developments in this field is the integration of NMs with surface‐enhanced Raman scattering (SERS) spectroscopy. SERS is a powerful analytical technique that enhances the Raman intensity of molecules, allowing for highly sensitive detection and analysis of trace amounts of substances. This integration offers highly precise and localized ultrasensing capabilities. The combination of NMs with SERS can also facilitate real‐time imaging inside living organisms. This has immense potential in chemical and cell biology and medical diagnostics and prognosis. Herein this review describes the types of NMs and their fabrication, the incorporation of plasmonic nanostructures, capable of creating strong electromagnetic fields when illuminated by light, which in turn enhances the Raman signals significantly, their applications, and their future prospects in areas such as precision medicine, environmental monitoring, and possibly even in new realms like microscale robotics and targeted therapeutics.

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Section: Nano/micromotorsmentioning

confidence: 99%

Nano/Micromotor‐Driven SERS for Highly Sensitive and Spatially Controlled Sensing

Becerril‐Castro,

Salgueiriño,

Correa‐Duarte

et al. 2023

Adv Funct Materials

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“…In recent years, the innovations in magnetic robots have mainly focused on materials, fabrication techniques, structure designs, and locomotion mechanisms. A variety of magnetic robots have been prepared by various methods including electrodeposition, , 3D printing, , chemical synthesis, and the biotemplate method. − Magnetic microrobots with spherical, helical, and tubular shapes have been designed for microsurgery and drug delivery. However, the small dimensions of single micro-/nanorobots also led to the disadvantages of limited capacity for drug loading and locomotion.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Magnetic Hydrogel Robot with Multimodal Locomotion for Targeted Cargo Delivery

Chen

Tian

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Recent strides in the development of untethered miniature robots have shown the advantages of diverse actuation methods, flexible maneuverability, and precise locomotion control, which has made miniature robots attractive for biomedical applications such as drug delivery, minimally invasive surgery, and disease diagnosis. However, biocompatibility and environmental adaptability are among the challenges for further in vivo applications of miniature robots due to the sophisticated physiological environment. Herein, we propose a biodegradable magnetic hydrogel robot (BMHR) that possesses precise locomotion with four stable motion modes, namely tumbling mode, precession mode, spinning-XY mode, and spinning-Z mode. Using a homemade vision-guided magnetic driving system, the BMHR can achieve flexible conversion between the different motion modes to cope with changes in complex environments, and its superior ability to cross obstacles is demonstrated. In addition, the transformation mechanism between different motion modes is analyzed and simulated. Benefiting from the diverse motion modes, the proposed BMHR has promising applications in drug delivery, showing remarkable effectiveness in targeted cargo delivery. The BMHR’s biocompatible property, multimodal locomotion, and functionality with drug-loaded particles can provide a new perspective to combine miniature robots with biomedical applications.

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“…Accordingly, such machines were not able to support the real-time regulation of magnetization or morphology locally in the small lumens of the human body. Drawing inspiration from the soft movements of natural organisms, − magnetization reprogrammability during navigation is of utmost importance for soft robots to reconfigure the morphologies and execute adaptive multimodal locomotion for continuously performing biomedical missions in real lumen scenarios.…”

mentioning

confidence: 99%

Soft Millirobot Capable of Switching Motion Modes on the Fly for Targeted Drug Delivery in the Oviduct

Liu,

Huang,

Liu

et al. 2024

ACS Nano

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Small-scale magnetic robots with fixed magnetizations have limited locomotion modes, restricting their applications in complex environments in vivo.Here we present a morphology-reconfigurable millirobot that can switch the locomotion modes locally by reprogramming its magnetizations during navigation, in response to distinct magnetic field patterns. By continuously switching its locomotion modes between the high-velocity rigid motion and high-adaptability soft actuation, the millirobot efficiently navigates in small lumens with intricate internal structures and complex surface topographies. As demonstrations, the millirobot performs multimodal locomotion including woodlouse-like rolling and flipping, sperm-like rotating, and snake-like gliding to negotiate different terrains, including the unrestricted channel and high platform, narrow channel, and solid−liquid interface, respectively. Finally, we demonstrate the drug delivery capability of the millirobot through the oviduct-mimicking phantom and ex vivo oviduct. The magnetization reprogramming strategy during navigation represents a promising approach for developing self-adaptive robots for performing complex tasks in vivo.

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Anisotropic magnetized tubular microrobots for bioinspired adaptive locomotion

Cited by 11 publications

References 48 publications

Nano/Micromotor‐Driven SERS for Highly Sensitive and Spatially Controlled Sensing

Nano/Micromotor‐Driven SERS for Highly Sensitive and Spatially Controlled Sensing

Biodegradable Magnetic Hydrogel Robot with Multimodal Locomotion for Targeted Cargo Delivery

Soft Millirobot Capable of Switching Motion Modes on the Fly for Targeted Drug Delivery in the Oviduct

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