We have compared the magnetoresistance of organic spin-valve (SV) structures with regioregular and regiorandom poly (3-hexylthiophene) (RR-P3HT and RRa-P3HT), hole transporting polymers, as the spacer layers sandwiched between two ferromagnetic electrodes. A SV structure of Fe 50 Co 50 /RRa-P3HT/Ni 81 Fe 19 was the test structure used. At room temperature, we observed the co-occurrence of two magnetoresistance effects, the spin magnetoresistance and magnetoresistance in the electrodes.Index Terms-Magnetoresistance, spin valves and spintronics.