Understanding correlation effects in topological phases and their transitions is a cutting-edge area of research in recent condensed matter physics. We study topological quantum phase transitions (TQPTs) between double-Weyl semimetals (DWSMs) and insulators, and argue that a novel class of quantum criticality appears at the TQPT characterized by emergent anisotropic non-Fermi liquid behaviors, in which the interplay between the Coulomb interaction and electronic critical modes induces not only anisotropic renormalization of the Coulomb interaction but also strongly correlated electronic excitation in three spatial dimensions. Using the standard renormalization group methods, large N f theory and the = 4 − d method with fermion flavor number N f and spatial dimension d, we obtain the anomalous dimensions of electrons (η f = 0.366/N f ) in large N f theory and the associated anisotropic scaling relations of various physical observables. Our results may be observed in candidate materials for DWSMs such as HgCr2Se4 or SrSi2 when the system undergoes a TQPT.Introduction. -Quantum criticality and topology play key roles in modern condensed matter physics [1][2][3][4][5], and the two concepts become naturally important near TQPTs. Recently, there has been a surge of interest in TQPTs [6][7][8][9][10][11]. The simplest class is described by the weakly interacting Dirac fermions, and it is well understood that the sign of the Dirac mass terms determines adjacent topological phases [12][13][14]. Since quasiparticles are well defined, non-interacting tight-binding models are sufficient to describe TQPTs in this class.Beyond the simplest class, however, our understanding of TQPTs is far from complete. The long-range Coulomb interaction may drastically change the properties of non-interacting fermions near TQPTs, and the non-interacting tight-binding models cannot describe some classes of TQPTs. The interplay between critical electronic modes and the Coulomb interaction becomes significant, and quantum critical non-Fermi-liquid states may appear with emergent particle-hole and rotational symmetries [15][16][17][18][19]. Moreover, the interplay may also give rise to weakly coupled but infinitely anisotropic excitations in a class of TQPTs [20][21][22][23][24]. Thus, it is vital to deepen our understanding of TQPTs beyond the simplest class.In this work, we uncover a novel class of TQPTs which shows emergent anisotropic non-Fermi-liquid behaviors in three spatial dimensions (3d) associated with topological nature of electronic wave functions. Our target system is the DWSM adjacent to insulator phases under the long-range Coulomb interaction. The presence of either the fourfold (C 4 ) or sixfold (C 6 ) rotational symmetry allows a direct phase transition between DWSMs and insulators whose bare Hamiltonian has a quadratic band * These authors contributed equally to this work. † egmoon@kaist.ac.kr ‡ hmin@snu.ac.kr touching spectrum. Without the symmetries, double-Weyl nodes may split into two Weyl nodes. The longrange Coulomb inte...