Ankle Brachial Index as a Marker of Atherosclerosis in Chinese Patients with High Cardiovascular Risk

Hasimu, Buaijiaer; Li, Jue; Nakayama, Tomohiro; Yu, Jinming; Yang, Jae Wook; Li, Xiankai; Hu, Dayi

doi:10.1291/hypres.29.23

Cited by 45 publications

(33 citation statements)

References 30 publications

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“…A prevalence of 26% of PAD in high-risk patients was reported at baseline in our previous research. 10 Compared with those with ABI of 1.00-1.4, those with ABI p0.4 coexist significantly with a variety of CVD risk factors, such as a higher prevalence of hypertension, diabetes and stroke. There was an increasing tendency in the prevalence of hypertension, diabetes, and coronary artery disease with ABI decreasing at baseline ( Table 1).…”

Section: Discussionmentioning

confidence: 98%

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Relationship of ankle–brachial index with all-cause mortality and cardiovascular mortality after a 3-year follow-up: the China ankle–brachial index cohort study

Luo²,

et al. 2009

J Hum Hypertens

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This study aimed to investigate the relationship of anklebrachial index (ABI) with all-cause mortality and cardiovascular (CV) mortality in Chinese inpatients after 3 years of follow-up. All the participants were inpatients at high risk of atherosclerosis and enrolled from July to November 2004. A total of 3210 patients were followed up until an end point was reached or until February 2008. The mean follow-up time was 37.65±1.54 months. Patients with ABI p0.4 were significantly older than other ABI categories (Po0.001) at baseline. The all-cause and CV disease (CVD) mortality were highest (37.7 and 27.5%, respectively) after a 3-year follow-up in patients with ABI p0.4. There was a significant increasing tendency in mortality with decreasing ABI levels (Po0.001). The Kaplan-Meier curves of survival showed a decreasing survival rate with the ABI decreasing, not only for all-cause mortality but also for CVD mortality (Po0.001). Adjusted for other risk factors, patients with ABI p0.4 were 3.105 times (95% CI 1.936-4.979) as likely to die as those with ABI in the range of 1.00-1.4; patients with ABI p0.4 were about five times (95% CI 2.740-8.388) as likely to die of CVD as those with ABI in the range of 1.00-1.4. Even patients with ABI in the range of 0.41-0.90 were more than 1.5 times as likely to die (relative risk ¼ 1.534, 95% CI 1.199-1.962), or die of CVD (relative risk ¼ 2.031, 95% CI 1.479-2.789) as those with ABI in the range of 1.00-1.4. Low ABI is related to a higher all-cause and CV mortality compared with normal ABI. ABI as a marker of atherosclerosis should be routinely evaluated to assess the risk of CV mortality in Chinese patients.

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Section: Discussionmentioning

confidence: 98%

“…10,11 An ABI 41.4 could be related to poor arterial compressibility resulting from stiffness and calcification, and we exclude those with ABI 41.4. An ABI p0.9 in either leg was considered as evidence of PAD.…”

Section: Abi Measurement and Classificationmentioning

confidence: 99%

Relationship of ankle–brachial index with all-cause mortality and cardiovascular mortality after a 3-year follow-up: the China ankle–brachial index cohort study

Luo²,

et al. 2009

J Hum Hypertens

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“…In the present study, we also found that in patients with the ABI≤ 0.90, the percentage of patients with diabetes and hypertension (high SBP) were higher than in the group with an ABI of 0.91-1.40. This result indicated that the contribution of the clustered components of MetS appeared to be additive, with the subjects having more CVD risk factors showing a substantially lower ABI than those with fewer risk factors in both sexes (22,23).…”

Section: Discussionmentioning

confidence: 95%

The Association between Ankle-Brachial Index and Cardiovascular or All-Cause Mortality in Metabolic Syndrome of Elderly Chinese

Luo

et al. 2007

Hypertens Res

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The ankle-brachial index (ABI) is a non-invasive, reliable measurement of lower-extremity ischemia. A low ABI is associated with increased risk of coronary heart disease, stroke and death. However, the relationship between ABI and all-cause mortality or cardiovascular disease (CVD) mortality in patients with metabolic syndrome (MetS) has not been well studied. Accordingly, we here investigated the association between ABI

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“…Previous studies have shown that 10-66% of patients with PAD also suffer from coronary artery disease [16][17][18] and 5-41% or more have cerebrovascular disease. [19][20][21] The Gruppo di Studio dell'Ischemia Cronica Critica degli Arti Inferiori (I.C.A.I. group) 9 demonstrated a 29.1% cardiovascular event rate (including 18.8% MIs and 10.3% strokes in the 2 years follow-up) of patients with CLI.…”

Section: Cardiovascular Eventsmentioning

confidence: 99%

Long-term safety of intramuscular gene transfer of non-viral FGF1 for peripheral artery disease

Niebuhr¹,

Henry

Goldman

et al. 2011

Gene Ther

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Ankle Brachial Index as a Marker of Atherosclerosis in Chinese Patients with High Cardiovascular Risk

Abstract: To obtain reliable data on the epidemiology, co-morbidities and risk factor profile of peripheral arterial disease (PAD), we evaluated the clinical significance of the ankle brachial index (ABI) as an indicator of PAD

Cited by 45 publications

References 30 publications

Relationship of ankle–brachial index with all-cause mortality and cardiovascular mortality after a 3-year follow-up: the China ankle–brachial index cohort study

Relationship of ankle–brachial index with all-cause mortality and cardiovascular mortality after a 3-year follow-up: the China ankle–brachial index cohort study

The Association between Ankle-Brachial Index and Cardiovascular or All-Cause Mortality in Metabolic Syndrome of Elderly Chinese

Long-term safety of intramuscular gene transfer of non-viral FGF1 for peripheral artery disease

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