Ankle Fractures

Gibly, Romie F.; Farber, Daniel A.; Schenker, Mara L.

doi:10.1007/978-3-319-72228-3_15

Cited by 2 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the adipose tissue is a common site for biomaterial supported delivery of endocrine cells (i.e. islets), [1][2][3][4][5] the field has yet to investigate biomaterial strategies to modulate this tissue's inherent endocrine function. Indeed, the adipose tissue regulates metabolism, immunity, reproduction, and many other processes required for homeostasis through the factors it secretes.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Delivery from Porous Poly(lactide-co-glycolide) Scaffolds Promotes an Anti-Inflammatory Environment within Visceral Adipose Tissue

Murphy

Hendley

Isely

et al. 2018

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

As biomaterial therapies emerge to address adipose tissue dysfunction that underlies metabolic disease, the immune response to these systems must be established. As a potential therapy, we are investigating resveratrol delivery from porous poly(lactide-co-glycolide) scaffolds designed to integrate with adipose tissue. Resveratrol was selected for its ability to protect mice and primates from high fat diet and broad anti-inflammatory properties. Herein, we report fabrication of scaffolds with high resveratrol loading that are stable and active for up to one year. In vitro release profiles indicate that drug release is biphasic with a burst release over 3 days followed by a plateau. Surprisingly, we find that PLG scaffold implanted into adipose tissue of mice promotes an anti-inflammatory environment characterized by high arginase-1 and low TNF-α and IL-6 compared to naïve unmanipulated fat. Resveratrol delivery from the scaffold augments this antiinflammatory environment by decreasing monocyte and lymphocyte numbers at the implant site and increasing expression of IL-10 and IL-13, cytokines that promote healthy adipose tissue. In terms of therapeutic applications, implant of scaffolds designed to release resveratrol into the visceral fat decreases MCP-1 expression in mice fed a high fat diet, a molecule that drives both local and systemic inflammation during obesity. Taken together, resveratrol delivery to adipose tissue using poly(lactide-co-glycolide) scaffolds is a promising therapeutic strategy for the treatment of adipose tissue inflammation that drives metabolic disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Resveratrol Delivery from Porous Poly(lactide-co-glycolide) Scaffolds Promotes an Anti-Inflammatory Environment within Visceral Adipose Tissue

Murphy

Hendley

Isely

et al. 2018

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…This was achieved by increasing the islet seeding density. The group also found that transplanting the constructs into the porcine omentum improved engraftment compared with gastric submucosa 205 . These investigators have since explored the use of microporous scaffolds to promote engraftment of pancreatic progenitors derived from stem cells.…”

Section: The Pancreasmentioning

confidence: 98%

Solid Organ Bioprinting: Strategies to Achieve Organ Function

2020

View full text Add to dashboard Cite

The field of tissue engineering has advanced over the last decade, but the largest impact on human health should be achieved with the transition of engineered solid organs to the clinic. The number of patients suffering from solid organ disease continues to increase, with over 100,000 patients on the US national waitlist and approximately 730,000 deaths in the United States resulting from end-stage organ disease annually. While flat, tubular, and hollow non-tubular engineered organs have already been implanted in patients, in vitro formation of a fully functional solid organ at a translatable scale has not yet been achieved. Thus, one major goal is to bioengineer complex, solid organs for transplantation, composed of patient-specific cells. Among the myriad of approaches attempted to engineer solid organs, 3D bioprinting offers unmatched potential. This review highlights the structural complexity which must be engineered at nano-, micro-, and mesostructural scales to enable organ function. We showcase key advances in bioprinting solid organs with complex vascular networks and functioning microstructures, advances in biomaterials science that have enabled this progress, the regulatory hurdles the field has yet to overcome, and cutting edge technologies that bring us closer to the promise of engineered solid organs.

show abstract

Ankle Fractures

Cited by 2 publications

References 58 publications

Resveratrol Delivery from Porous Poly(lactide-co-glycolide) Scaffolds Promotes an Anti-Inflammatory Environment within Visceral Adipose Tissue

Resveratrol Delivery from Porous Poly(lactide-co-glycolide) Scaffolds Promotes an Anti-Inflammatory Environment within Visceral Adipose Tissue

Solid Organ Bioprinting: Strategies to Achieve Organ Function

Contact Info

Product

Resources

About