2019
DOI: 10.1007/s11010-019-03508-9
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ANKRD49 inhibits etoposide-induced intrinsic apoptosis of GC-1 cells by modulating NF-κB signaling

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Cited by 6 publications
(7 citation statements)
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“…Notably, the NF‐κB signaling pathway was enriched (Figure 6B), and the DEGs were involved in cell adhesion, cell death, extracellular matrix organization and EMT, as indicated by GO analysis (Figure 6C). It has been reported that ankyrin repeat proteins can regulate the NF‐κB pathway, 21 and that the ANKRD protein family can regulate NF‐κB signaling pathway, 15,22,23 and also that the NF‐κB signaling pathway is involved in regulating EVT functions 24 . Therefore, we further explored the effects of ANKRD37 on NF‐κB signaling using Western blotting to detect the IκBα and p65 phosphorylation levels.…”
Section: Resultsmentioning
confidence: 99%
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“…Notably, the NF‐κB signaling pathway was enriched (Figure 6B), and the DEGs were involved in cell adhesion, cell death, extracellular matrix organization and EMT, as indicated by GO analysis (Figure 6C). It has been reported that ankyrin repeat proteins can regulate the NF‐κB pathway, 21 and that the ANKRD protein family can regulate NF‐κB signaling pathway, 15,22,23 and also that the NF‐κB signaling pathway is involved in regulating EVT functions 24 . Therefore, we further explored the effects of ANKRD37 on NF‐κB signaling using Western blotting to detect the IκBα and p65 phosphorylation levels.…”
Section: Resultsmentioning
confidence: 99%
“…For example, ANKRD26 can regulate kisspeptin‐GPR54 signaling to mediate neuronal movement by inhibiting cell migration 14 . ANKRD49 can inhibit the apoptosis of GC‐1 spermatogonia through the nuclear factor‐kappa B (NF‐κB) signaling pathway and participates in spermatogenesis 15 . ANKRD37 is a member of the ANKRD protein family that is degraded through the ubiquitin system mediated by Fem1b 16 , and is involved in regulating cell growth and HIF‐1a‐induced autophagy in colon cancer 17 .…”
Section: Introductionmentioning
confidence: 99%
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“…Next, the cells were digested by 0.25% trypsin and centrifuged at 2,000 rpm for 5 minutes. The acquired cells were stained with annexin V-fluorescein isothiocyanate (FITC) to quantify the percentage of cells undergoing apoptosis, whereas the necrotic cells were counterstained with propidium iodide (PI) as previously described [ 19 ]. Apoptosis was analyzed using flow cytometry (BD Biosciences, Franklin Lakes, NJ, USA).…”
Section: Methodsmentioning
confidence: 99%
“…ANKRD49 (ankyrin repeat domain 49) contains four ankyrin motifs. ANKRD49 is highly expressed in the testes and is involved in spermatogenesis(Wang et al, 2015; Zhou et al, 2019). ANKRD49 also participates in the progression of malignant gliomas and gastric cancer in humans(Hao et al, 2017; Liu et al, 2018).…”
Section: Introductionmentioning
confidence: 99%