Anmerkungen zur Pathogenese des Morbus Behçet

Abstract

The etiology and pathogenesis of Behçet's syndrome remains unclear. It has been postulated that an infectious agent may induce an immune-mediated, generalized vasculitis in genetically predisposed individuals (HLA-B51 +). There is accumulating evidence that an abnormality of the innate and adaptive immune response, e.g. directed against heat shock proteins plays an important role in Behçet's syndrome. This article is intended to evaluate the more recent knowledge on this disorder and evaluate new therapeutic options.

High prevalence of Helicobacter pylori infection in Behcet’s disease

“…The possible mechanism of action of bacterial infections including H. pylori in the pathogensis of BD may involve molecular homology of bacterial antigens and human heat shock protein (HSP) which is now proposed as the possible antigen in BD [3,4]. This antigen is expressed outside of cellular membrane in response to shock and other stresses and physiologic stimuli.…”

“…It has clear differences with many other rheumatologic disorders which have autoimmune basis in their pathogenesis and the role of environmental factors were considered prominent in this disease [2-4]. …”