Wireless communications in aircraft cabin environments have drawn widespread attention with the increase of application requirements. To ensure reliable and stable in-cabin communications, the investigation of channel parameters such as path loss is necessary. In this paper, four machine learning methods, including back propagation neural network (BPNN), support vector regression (SVR), random forest, and AdaBoost, are used to build path loss prediction models for an MD-82 aircraft cabin. Firstly, machine-learning-based models are designed to predict the path loss values at different locations at a fixed frequency. It is shown that these models fit the measured data well, e.g., at 2.4 GHz central frequency the root mean square errors (RMSEs) of BPNN, SVR, random forest, and AdaBoost predictors are 1.90 dB, 2.20 dB, 1.76 dB, and 2.12 dB. Subsequent research is engaged to forecast path loss at a new frequency based on available information at known frequencies. Additionally, to solve the data limitation problem at the new frequency, we propose a path loss prediction scheme combining empirical models and machinelearning-based models. This scheme uses estimated values generated by the empirical model according to prior information to expand the training set. To verify the performance of this scheme, measured samples at 2.4 GHz and 3.52 GHz, as well as samples generated by the empirical model are employed as the training set for the path loss prediction at 5.8 GHz. The RMSEs of BPNN, SVR, random forest, and AdaBoost models are 2.49 dB, 2.78 dB, 2.54 dB, and 3.76 dB. In contrast, without samples generated by the empirical model, the RMSEs of those models are 3.84 dB, 4.94 dB, 6.57 dB, and 6.77 dB. Results show that the proposed data expansion scheme improves prediction performance when there are few measurement samples at the new frequency. INDEX TERMS Aircraft cabin, data expansion, machine learning, path loss prediction, propagation characteristics.