Annexin A2 in renal cell carcinoma: Expression, function, and prognostic significance

Yang, Shun Fa; Hsu, Han Lin; Chao, Tai-Kuang; Hsiao, Chia Jung; Lin, Yung Feng; Cheng, Chao

doi:10.1016/j.urolonc.2014.08.015

Cited by 37 publications

(34 citation statements)

References 33 publications

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“…Although molecular mechanisms underlying Anxa1‐dependent malignancy of RCC have been unknown, Anxa2 reportedly regulates RCC cell motility . Anxa2 and Anxa1 have approximately >50% homology in their amino acid sequences, and both have Ca 2+ ‐dependent actin filament‐binding activity within cholesterol‐rich membrane domains .…”

Section: Discussionmentioning

confidence: 99%

“…Although molecular mechanisms underlying Anxa1-dependent malignancy of RCC have been unknown, Anxa2 reportedly regulates RCC cell motility. 19 Anxa2 and Anxa1 have approximately >50% homology in their amino acid sequences, and both have Ca 2+ -dependent actin filament-binding activity within cholesterol-rich membrane domains. 20 Anxa2 regulates the organization of membrane-associated actin by promoting association of lipid microdomains or in conjunction with other actin-binding proteins, such as a-actin, ezrin and actin.…”

Section: Discussionmentioning

confidence: 99%

“…The present study was approved by the ethics committees of Asama General Hospital (no. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] and Shinshu University School of Medicine (no. 3627), and was undertaken in accordance with the Declaration of Helsinki.…”

Section: Introductionmentioning

confidence: 99%

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Annexin A1 expression is correlated with malignant potential of renal cell carcinoma

Yamanoi

Fujii

et al. 2018

Int J of Urology

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Objectives To evaluate the expression of annexin A1 protein in patients with renal cell carcinoma. Methods Annexin A1 expression was examined in renal cell carcinoma specimens from 27 patients, and their disease‐free survival was analyzed using the log–rank test. Annexin A1 knockdown in the human renal cell carcinoma cell line Caki‐1 was carried out, and its proliferation, invasion, motility and adhesion were compared with those of control cells. Results In 13 out of 27 patients, annexin A1 was highly expressed in the membrane of renal cell carcinoma tumor cells, whereas in the rest of the patients, annexin A1 expression was weak or negligible in the membrane of those cells. Patients with high annexin A1 expression had significantly poorer disease‐free survival than those with weak or negligible annexin A1 expression (P = 0.031). In the renal cell carcinoma cell line, annexin A1 knockdown cells showed significantly decreased proliferation, invasion, motility and adhesion relative to control cells, and expressed lower relative levels of membrane‐type 1 matrix metalloproteinase and hypoxia‐inducible factor 1‐alpha transcripts, showing a potential pathway regulated by annexin A1. Conclusion Annexin A1 is associated with renal cell carcinoma malignant potential and could serve as a marker of poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Annexin A1 expression is correlated with malignant potential of renal cell carcinoma

Yamanoi

Fujii

et al. 2018

Int J of Urology

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“…This occurs by the induction of cell cycle arrest at the G2 phase in non-small cell lung cancer cells and esophageal squamous cell carcinoma, which occur in a p53-dependent or -independent manner (27,28). Furthermore, it has been demonstrated that decreased Annexin A2 expression alters cell polarity, disrupts the formation of actin filaments and reduces C-X-C chemokine receptor type 4 expression via the Rho/Rock pathway in renal cell carcinoma (29). However, further studies are required to determine the mechanism by which Annexin A2 promotes the development of laryngeal cancer.…”

Section: Discussionmentioning

confidence: 99%

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Luo

Xie

et al. 2017

Exp Ther Med

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Abstract. Due to the lack of a definite diagnosis, a frequent recurrence rate and resistance to chemotherapy or radiotherapy, the clinical outcome for patients with advanced laryngeal cancer has not improved over the last decade. Annexin A2 is associated with the invasion and metastasis of cancer cells. In the present study, it was demonstrated using differential proteomics analysis that Annexin A2 is highly expressed in laryngeal carcinoma tissues and this was confirmed using immunohistochemistry, which demonstrated that the expression of Annexin A2 in laryngeal carcinoma tissues was significantly higher than in healthy adjacent tissue. In addition, its potential predictive value in the prognosis of patients with laryngeal carcinoma was evaluated. The results demonstrated that Annexin A2 expression was significantly associated with tumor size, lymph node metastasis, distant metastasis and clinical stage. In addition, higher Annexin A2 expression was associated with a poor prognosis of patients with laryngeal cancer. Thus, the results of the present study indicate that Annexin A2 expression is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer.

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“…Annexin A2 tetramers. (AIIt) can be used as co-receptor of t-PA and PLG, to regulate the produce of Plasmi and promote the tumor invasion and was correlated with clinical outcomes (Yang et al, 2014). Annexin A2 is reported to be overexpressed in a variety of cancers including lung cancer, colon cancer, gastric cancer, hepatocellular carcinoma and malignant glioma (Zheng and Jaffee, 2012).…”

Section: Discussionmentioning

confidence: 99%

Annexin A2 and CD105 Expression in Pancreatic Ductal Adenocarcinoma is Associated with Tumor Recurrence and Prognosis

Huang

Hong²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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To investigate the value of expression of annexin A2, microvessel density (MVD) and CD105 in pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent normal tissues, immunohistochemical staining was used. The positive expression rate of Annexin A2 and the MVD in pancreatic ductal adenocarcinoma tissues was higher than that in in adjacent normal tissues (p<0.005). Expression of Annexin A2 and MVD correlated with histological grade (p<0.05). MVD of cancers in TNM stage Ⅱb was higher than that in TNM stageⅠ~Ⅱa (p<0.026). Cancerous tissues with Annexin A2 staining grade 3+ had lower MVD than the tissues with the other Annexin A2 staining grade (p<0.05). Patients with high MVD had worse prognosis. However , our study did not confirm Annexin A2 was an independent risk factor for patients with PDAC. We confirmed MVD labeled by CD105 was an independent risk factor for patients with PDAC and had moderate predictive value of prognosis.

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Annexin A2 in renal cell carcinoma: Expression, function, and prognostic significance

Cited by 37 publications

References 33 publications

Annexin A1 expression is correlated with malignant potential of renal cell carcinoma

Annexin A1 expression is correlated with malignant potential of renal cell carcinoma

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Annexin A2 and CD105 Expression in Pancreatic Ductal Adenocarcinoma is Associated with Tumor Recurrence and Prognosis

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