Annonaceous acetogenins: An updated review

Fang, Xiaowen; Rieser, Matthew J.; Gu, Zhe‐Ming; Zhao, Geng‐Xian; McLaughlin, Jerry L.

doi:10.1002/pca.2800040108

Cited by 228 publications

(205 citation statements)

References 61 publications

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“…squamosa (96h LC 50 -36.19mg/l and 34.30mg/l) was more toxic than the other combination. It has been reported that the toxicity of anno-naceous acetogenins found cytotoxic and antitumor activity (Fang et al, 1993). It behaves as bioenhancer and enhances the antimicrobial effect of antibiotics many fold (Khanuja et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Binary Combination of Different Breeds of Freeze-Dried Cow Urine (FCU) with Some Plant Molluscicides against Lymnaea acuminata: Vector of Fasciolosis

Kumar¹,

Singh²,

Singh³

2012

ALS

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Molluscicidal activity of binary combination of different breeds of freeze-dried cow urine (FCU) such asSahiwal, Geer and Tharparkar with plant molluscicides viz Annona squamosa seed powder, Azadirachta indica oil, Ferula asafoetida root latex and Camellia sinensis against harmful snail Lymnaea acuminata have been studied. It was observed that the toxicity of binary combination (1:1) of plant molluscicides and different breeds of freeze-dried cow urine (FCU) kept for 15 days in sunlight (8h/day) and laboratory condition were toxic against L. acuminata. Among all combinations, the toxicity of Sahiwal freeze-dried cow urine + A. squamosa (24h LC 50 -97.27mg/l and 96h LC 50 -36.19mg/l) kept for 15 days in sunlight (8h/day) was higher than the Geer and Tharparkar freeze-dried cow urine. Toxicity of laboratory condition of Sahiwal freeze-dried cow urine + A. squamosa (24h LC 50 -81.40mg/l and 96h LC 50 -34.30mg/l) was more toxic than other binary combination of cow breeds and plants molluscicides. The different breeds of cow urine under the 15 days sunlight (8h/day) and laboratory conditions freeze-dried with different plant molluscicides are potent molluscicides.

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Section: Discussionmentioning

confidence: 99%

Binary Combination of Different Breeds of Freeze-Dried Cow Urine (FCU) with Some Plant Molluscicides against Lymnaea acuminata: Vector of Fasciolosis

Kumar¹,

Singh²,

Singh³

2012

ALS

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“…Les acCtogCnines de sept espkces, A. bullata, A. cherimolia, A. densicoma, A. montana, A. muricata, A. reticulata et A. squamosa (2) ont fait pour le moment l'objet d7Ctudes approfondies. Annona senegalensis n'a jusqu'h prCsent fait l'objet d'aucune recherche dans ce domaine.…”

Section: Introductionunclassified

Senegalene, une nouvelle acétogénine oléfinique mono-tétrahydrofuranique des graines d'Annona senegalensis

Şahpaz¹,

Laurens²,

Hocquemiller³

et al. 1994

Can. J. Chem.

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Using activity-directed fractionation, the chromatography of the bioactive methanol extract of Annona senegalensis seeds led to isolation of a new mono-tetrahydrofuranic γ-lactone acetogenin characterized by the presence of a double bond on the alkyl chain, senegalene 1. Its structure was elucidated on the basis of spectroscopic (2D-NMR and MS) and chemical methods. Four known acetogenins have been also isolated: molvizarin 2, asimicin 3, rolliniastatin-2 4, and squamocin 5. Comparative structure–activity relationships were studied using senegalene 1 and its derivatives in KB and VERO cell lines in in vitro tests.

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“…Annonaceous acetogenins, a relatively new [1][2][3][4][5] class of natural products isolated from the Annonaceae family, have attracted considerable attention in recent years. The unusually broad spectrum of bioactivity, especially the extraordinarily high cytotoxicity to a variety of tumor cell lines, shown by numerous members of this class of compounds have encouraged many synthetic endeavors.…”

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confidence: 99%