Annonaceous acetogenins: The unrevealed area for cytotoxic and pesticidal activities

Gupta, Abhishek; Pandey, Sonia; Dr, Shah; Js, Yadav; Nr, Seth

doi:10.4103/0975-8453.86299

Cited by 38 publications

(27 citation statements)

References 32 publications

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“…Son exclusivas de la familia Annonáceas, y se encuentran particularmente en especies de los géneros Annona, Asimina, Uvaria, Rollinia y Goniothalamus, entre otros. Estos compuestos se conocen por ser potentes inhibidores de la cadena respiratoria mitocondrial (CRM), concretamente de la NADH-ubiquinona óxidoreductasa (complejo I) (TORMO et al, 2003a;BERMEJO et al, 2005;DUVAL et al, 2006a;DUVAL et al, 2006b;GUPTA et al, 2011). De hecho, las ACG de Annonáceas han mostrado mayor potencia que los inhibidores clásicos de la CRM, tales como rotenona y piericidin A (DEGLI ESPOSTI et al, 1994) …”

Section: Resultados Y Discusión Acetogeninasunclassified

Nuevos fármacos inspirados en Annonáceas

et al. 2014

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RESUMEN -Los metabolitos secundarios activos (MSA) juegan un papel importante en el descubrimiento de nuevos medicamentos. Moléculas naturales con esqueletos complejos, tales como las estatinas aisladas de Aspergillus terreus, o las acetogeninas específicas de la familia Annonaceae, no hubieran podido ser inventadas en ningún laboratorio. Los MSA aislados en Annonaceae, especialmente las acetogeninas y los alcaloides isoquinoleínicos, pueden ser considerados como fuente constante de inspiración para químicos, farmacólogos y para todos los investigadores interesados en el descubrimiento de una nueva familia de medicamentos. Terminos para indexacion: Annonaceae, acetogeninas, antitumorales, insecticidas, alcaloides isoquinoleínicos, dopaminérgicos, antimicrobianos. NEW MEDICINES INSPIRATED IN ANNONACEASABSTRACT -Active secondary metabolites (ASM) play a highly significant role in the drug discovery. Natural complex chemical skeleton such as statins isolated from Aspergillus terreus, or acetogenins specific from Annonaceae family, are not able to be invented in any laboratory. The ASM isolated from Annonaces, especially acetogenins and isoquinoline alkaloids should be considered as a source of continuous inspiration for the chemists, the pharmacologists and all researchers that are interested in discovering a new drug family. Los metabolitos secundarios (MS) han sido la principal fuente de diversidad química que ha dirigido el descubrimiento y desarrollo de nuevos agentes terapéuticos en el siglo pasado. Muchos productos de origen natural o análogos estructurales preparados por síntesis, han sido desarrollados con éxito para combatir enfermedades humanas en prácticamente todas las áreas terapéuticas. La época posterior al descubrimiento de la penicilina, durante la segunda guerra mundial, fue la más floreciente en cuanto a los esfuerzos dedicados por las empresas farmacéuticas al descubrimiento de nuevos metabolitos secundarios activos (MSA), moléculas de origen natural con interés terapéutico, centradas principalmente en la búsqueda de antibióticos (Figura 1).Pero estos esfuerzos no se dirigieron únicamente al desarrollo de compuestos antibacterianos o antifúngicos sino que también se amplió el objetivo a otras enfermedades no infecciosas. Así en los años 70, como ejemplo, se desarrollaron la mevastatina, aislada en cultivos de Penicillium citrinum y la lovastatina aislada a partir de un extracto del hongo Aspergillus terreus, como inhibidores de la biosíntesis de colesterol en el hígado, que son la base principal del tratamiento actual de las nuevas estatinas de síntesis (BAKER et al., 2007).Sin embargo, a pesar de estos éxitos indudables la gran industria farmacéutica disminuyó el interés por la investigación en productos naturales a lo largo de los años 90 y principios de la década del 2000, para focalizar la búsqueda de nuevos compuestos activos mediante el rastreo automatizado a gran escala (high throughpout screening, HTS) aplicados a librerías de compuestos generados por la química combinatoria (NEWMAN e C...

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Section: Resultados Y Discusión Acetogeninasunclassified

Nuevos fármacos inspirados en Annonáceas

et al. 2014

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“…9 The primary site of action of the acetogenins is complex I of the electron transport chain in mitochondria. 10 Study in mice showed that annonacin inhibited the normal growth of lung tumors during two-weeks period. 11 Phytochemical assessment of A. muricata leaves showed the presence of alkaloids, tannins, flavonoids, saponins, anthraquinones and cardiac glycosides, ellagic acid, polyphenolic compounds, triterpenoids, β-sistosterol.…”

Section: Medical Journal Of Indonesiamentioning

confidence: 99%

“…[10][11] Data from previous study on colon cancer cell lines suggested that there were pathways for 5-FU resistance including altered regulation of nucleotide metabolism, amino acid metabolism, cytoskeleton organization, transport, and oxygen metabolism. 20 The cytotoxicity of acetogenins has been shown to be stronger in tumorous than in normal cells.…”

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“…The primary site of action of the acetogenins is complex I of the electron transport chain in mitochondria. 10 Acetogenins have also been shown being the potent inhibitors of NADH oxidase in plasma membranes of cancerous liver cells. Specifically, the bis-THF acetogenin bullatacin was shown to be a strong inhibitor of this enzyme in liver cancer cell; however, bullatacin showed no inhibition of the NADH oxidase against "normalized" liver cells.…”

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Antiproliferative activity and caspase enhancement properties of <em>Annona muricata</em> leaves extract against colorectal cancer cells

et al. 2016

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“…It has been shown that plant metabolites can have repellent effects, contact toxicity, inhibit enzymatic processes, and change reproductive variables, which kill or reduce the reproductive performance of mites (LÜMMEN, 1998;LABORDA et al, 2013;. Numerous plant families are known to produce metabolites that are toxic to these phytophagous mites, among which, the Annonaceae family deserves special attention, because there have been many intensive studies that have evaluated this family's use as a pesticide producers (MCLAUGHLIN, 2008;GUPTA et al, 2011;MADHUMITHA et al, 2012). This study aimed to evaluate the bioactivity of dichloromethane soluble fractions from methanol extracts of plants from the Annonaceae family, originating from the Alto do Rio Grande region in Minas Gerais, Brazil, against a Cuban population of T. tumidus.…”

Section: Introductionmentioning

confidence: 99%

Acaricidal activity of Annonaceae fractions against Tetranychus tumidus and Tetranychus urticae (Acari: Tetranychidae) and the metabolite profile of Duguetia lanceolata (Annonaceae) using GC-MS

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et al. 2015

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Species of the Tetranychus genus feed on plant tissues, which reduces the rate of photosynthesis and can lead to the death of plant tissues. As a result, considerable production losses are caused by these arthropods. Thus, in order to aid in the development of new products for the control of Tetranychus tumidus Banks and Tetranychus urticae Koch (Acari: Tetranychidae), the initial objective of this study was to select Annonaceae derived fractions that were soluble in dichloromethane and have acaricidal activity. Then, an exploratory analysis of the metabolite profile of the most successful fraction was performed by gas chromatography-mass spectrometry (GC-MS). Among the dichloromethane soluble fractions derived from Annona cacans Warm., Annona coriacea Mart., Annona neolaurifolia H. Rainer, Annona sylvatica A.St.-Hil., Duguetia lanceolata A.St.-Hil., Guatteria australis A.St.-Hil., Xylopia brasiliensis Spreng., Xylopia emarginata Mart. and Xylopia sericea A.St.-Hil., only the fraction from D. lanceolata stem bark reduced the survival of T. tumidus females. However, ovicidal activity was not detected when D. lanceolata stem bark was evaluated against T. tumidus eggs. Further, we studied the effect of dichloromethane soluble fractions from D. lanceolata leaves, berry fruits and stem bark on T. urticae, and the stem bark was found to be the most active fraction against T. urticae. The metabolite profile analysis of D. lanceolata stem bark by GC-MS, suggested that the main constituents were 2,4,5-trimethoxystyrene and trans-asarone. Key words: Botanic acaricide, secondary metabolites, 1,2,4-trimethoxy-5-vinylbenzene, 1,2,4-trimethoxy-5-[(1E)-1-propen-1-yl]benzene ResumoAs espécies do gênero Tetranychus alimentam-se de tecidos vegetais acarretando redução na capacidade fotossintética da planta, que pode resultar em morte dos tecidos vegetais, como consequência são

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Annonaceous acetogenins: The unrevealed area for cytotoxic and pesticidal activities

Cited by 38 publications

References 32 publications

Nuevos fármacos inspirados en Annonáceas

Nuevos fármacos inspirados en Annonáceas

Antiproliferative activity and caspase enhancement properties of <em>Annona muricata</em> leaves extract against colorectal cancer cells

Acaricidal activity of Annonaceae fractions against Tetranychus tumidus and Tetranychus urticae (Acari: Tetranychidae) and the metabolite profile of Duguetia lanceolata (Annonaceae) using GC-MS

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