Antiproliferative activity and caspase enhancement properties of &lt;em&gt;Annona muricata&lt;/em&gt; leaves extract against colorectal cancer cells

Indrawati, Lili; Ascobat, Purwanty Astuti; Bela, Budiman; Abdullah, Murdani; Surono, Ingrid S.; Pramono, Suwijiyo

doi:10.13181/mji.v25i3.1449

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…Meanwhile, caspase-8 activity in CRC cells after treatment with serum from patients receiving placebo group showed no changes pre and post treatment (0.19, 95% CI 0.16-0.23 VS 0.19, 95% CI 0.16-0.23, p = 0.433). In summary, this study exhibited that ESFAM induced cytotoxic activities in CRC cells through significant elevation of caspase-9 activity (Indrawati et al, 2016).…”

Section: A Muricata Leaf Extract In Treatments For Crc Patientsmentioning

confidence: 56%

The Effects of Simvastatin and Soursop (Annona muricata) Leaf Extract on Colorectal Cancer

Amadea

Atrasina

2021

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Colorectal cancer (CRC) is a heterogeneous disease of the colon and rectum. In Indonesia, CRC has the fourth highest cancer incidence, with about 30,000 new cases and causing around 16,000 deaths per year. Numerous studies have shown the benefits of using simvastatin and Annona muricata (A. muricata) leaf extract to promote cytotoxic effects in CRC cells. This systematic review aimed to evaluate the effects and the possible molecular mechanisms of actions used by simvastatin and A. muricata leaf extract to exert anti-cancer effects in CRC cells. We synthesized published studies on the effect of simvastatin and A. muricata leaf extract in in vitro and in vivo CRC studies, and highlighted the potential application of simvastatin and A. muricata leaf extract in combination with other anti-cancer treatments. This systematic review was written in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Simvastatin and A. muricata leaf extract were shown to suppress CRC cell growth and proliferation and generate a synergistic effect when combined with other anti-cancer treatments. Several possible mechanisms of actions of simvastatin include bone morphogenetic protein (BMP) pathway and mevalonate pathway activation, ERKs inactivation, and regulation of the yes-associated protein 1 (YAP1), while for A. muricata leaf extract, possible mechanisms of actions include intrinsic apoptosis pathway activation, cytochrome c-mediated apoptosis, mitochondria-mediated apoptosis, and programmed cell death initiation. Further experimental evidence is needed to determine the specific mechanisms on how simvastatin and A. muricata leaf extract induce anti-cancer effects against CRC cells.

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Section: A Muricata Leaf Extract In Treatments For Crc Patientsmentioning

confidence: 56%

The Effects of Simvastatin and Soursop (Annona muricata) Leaf Extract on Colorectal Cancer

Amadea

Atrasina

2021

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“…The inhibitory activity of the ligands reticuline and coclaurine with these anti-cancer receptors are thought to be potential therapeutic targets was investigated before using multi-receptor docking and for In-silico studies [65]. The optimum docked pose of structure was chosen based on the lowest binding energy interacting residues, and hydrogen bond number [66]. Among the alkaloids, reticuline had the best docked postures and the highest interactive energy [67].…”

Section: Discussionmentioning

confidence: 99%

In Silico Molecular Docking Analysis of the Potential role of Reticuline and Coclaurine as Anti-colorectal Cancer Alkaloids

Al-Zahrani¹,

Alghamdi²

2022

JPRI

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Background: Colorectal cancer (CRC) is a serious global epidemic, being the third most prevalent cancer worldwide, finding novel treatment alternatives for CRC is thus of the greatest importance. The atomic level interaction between a tiny molecule and a protein can be represented using molecular docking. Molecular docking is critical for visualizing ligand-protein interactions at the atomic level highlighting our knowledge of ligands behavior, which aids in the development of structure-based drugs. Methods: We used molecular docking to investigate the anticancer activity for two main ligands (reticuline and coclaurine) and four potential anticancer receptors (TNIK, VEGFR, EGFR and AKT2). Protein Data Bank provided the 3D structures of the receptor proteins, iGEMDOCK and AutoDock vina program were used for molecular docking. Results: Reticuline had the best docked postures and the highest interactive energy with CRC receptors: TNIK, VEGFR, EGFR and AKT2 with the following binding energy; -96.7, -117.8, -120.2, and -108.3 kcal/mol accordingly. Conclusion: According to this study, the investigated ligands were successfully docked onto reticuline and coclaurine ligands for drug interaction studies, the calculated binding energy demonstrate their importance as an anti-carcinogenic target. The current findings lay the groundwork for further research into reticuline and coclaurine as a potential CRC therapeutic option.

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“…In vitro studies and cytotoxicity test in animal, also clinical trial have been conducted using the extract of these leaves. [9][10] This study aims to analyse the potential of Annona muricata leaves extract to be an anti-colon cancer by investigating the extract capability in reducing serum level of ICAM-1 and VCAM-1.…”

Section: Introductionmentioning

confidence: 99%

The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model

Indrawati

Kusmardi

Wiyanto

2023

InaJGHE

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Background: Annona muricata leaves are used as traditional tea drink that is currently being studied on the developing effort of treating some types of cancers because they are known as anti-cancer. Motivated by that usage, this study aims to analyse the potential of A. muricata leaves extract to be an anti-colon cancer by investigating the extract capability in reducing blood intercellular cell-adhesion molecule-1 (ICAM-1) and vascular cell-adhesion molecule-1 (VCAM-1).Method: The research was conducted in Faculty of Medicine Universitas Indonesia with an experimental design. A. muricata leaves extract was tested in vivo. In vivo test was conducted to Swiss Webster mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). Statistical analysis used was SPSS.Results: EIFAM reduce the serum level of ICAM-1 and VCAM-1. EIFAM significantly reduce serum level of VCAM compare to ESFAM.Conclusion: Ethanol insoluble fraction of Annona muricata leaves water extract of is potential to be an anti-colon cancer proven by the extract capability to reduce ICAM-1 and VCAM-1.

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Antiproliferative activity and caspase enhancement properties of <em>Annona muricata</em> leaves extract against colorectal cancer cells

Cited by 6 publications

References 15 publications

The Effects of Simvastatin and Soursop (Annona muricata) Leaf Extract on Colorectal Cancer

The Effects of Simvastatin and Soursop (Annona muricata) Leaf Extract on Colorectal Cancer

In Silico Molecular Docking Analysis of the Potential role of Reticuline and Coclaurine as Anti-colorectal Cancer Alkaloids

The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model

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