Annular elastolytic giant cell granuloma in an infant: Improvement after treatment with oral tranilast and topical pimecrolimus

Elastolytic Actinic Giant Cell Granuloma

“…42,43 This condition affects both sexes equally, 2 although a preponderance of female patients has been also reported in other series. 11,13 Besides the clinical variants than have been reported, O'Brien 17 also described 4 pathologic variants of AG.…”

“…Topical, 18,69 intralesional, 29,70 and systemic 21,44 corticosteroids have been used with some benefit. Topical pimecrolimus 43 and tacrolimus 33 have been reported as an effective therapy. Phototherapy, including narrow band UVB, 71 Psoralen-UVA (PUVA), 72 and Retinoids-Psoralen-UVA (Re-PUVA), can be also an effective treatment.…”

Effective treatment with hydroxychloroquine in a case of annular elastolytic giant cell granuloma

“…[8] Treatments achieving successful results include intralesional or systemic corticosteroids, excision of a solitary lesion, retinoid-PUVA, cyclosporine, topical tacrolimus, tranilast with topical pimecrolimus or topical steroids, dapsone, fumaric acid esters, narrowband UVB, and quinacrine. [2,3,[9][10][11][12][13][14] In contrast, topical corticosteroids, PUVA, cauterization, cryotherapy, methotrexate, and isotretinoin were found to be unsuccessful. [2,15] In addition to that, clofazimine has been reported as both effective [16] and ineffective [2] in two separate cases.…”

Tranilast: A review of its therapeutic applications

“…A case of AEGCG (an 8-month-old infant) was successfully treated with combination therapy of oral tranilast and topical pimecrolimus [200] Lichenoid cutaneous sarcoidosis A 76-year-old Japanese man was successfully treated with tranilast [201] Lacrimal gland chronic GVHD (cGVHD)…”