Annulate Lamellae in Erythroblasts in the Mice Splenic Colonies

Miura, Akira B.; Yoshida, Kenichi; Yamaguchi, Akihiko; Fukuda, Mitsuyuki

doi:10.1620/tjem.124.387

Cited by 4 publications

(1 citation statement)

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“…Annulate lamellae observed in the TAP administered mice in this study are a rare occurrence in the erythroblasts, and a detailed report of these findings had been made elsewhere (Miura et al 1978a). …”

Section: Discussionsupporting

confidence: 67%

The Effect of Chloramphenicol and Thiamphenicol on the Ultrastructure of the Erythroblasts in Mouse Splenic Colonies

Miura

Yoshida

Yamaguchi

et al. 1980

Tohoku J. Exp. Med.

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The Effect of Chloramphenicol and Thiamphenicol on the Ultrastructure of the Erythroblasts in Mouse Splenic Colonies. Tohoku J. exp. Med., 1980, 130 (4), 335-340 -Lethally irradiated mice were injected with 1 x 105 normal bone marrow cells taken from mice of the same strain. They were divided into two groups: One was given chloramphenicol (CAP) or thiamphenicol (TAP) in an early stage after marrow transfusion and the other in a later stage. In both groups, more prominently in the former group, some ultrastructural changes were recognized in mitochondria of the early erythroblasts. Mitochondria increased in number and became swollen with electron lucent matrix and paucity of cristae. Condensed mitochondria described in earlier reports were never observed. Intermediate or late erythroblasts seen only in the latter group did not show such alterations. Mitochondrial changes in the early erythroblasts were considered to reflect the dose-related toxic effects of CAP and TAP, and it is assumed that these drugs affect the development of erythroblasts in a very early stage. chloramphenicol; thiamphenicol; ultrastructure of erythroblasts; mouse splenic colony Chloramphenicol (CAP) is known to cause two types of bone marrow injury by its toxic action. The pathogenesis of the more serious type of injury, bone marrow aplasia, is not well investigated because animal experiments on it are not yet successful. The other effect of this drug is a depressive action on mitochondria) protein synthesis, and thiamphenicol (TAP) is believed to have the same action.There have been several reports on the mitocbondrial changes of hemopoietic cells in human bone marrow, but a few descriptions are available as for those in experimental animals under various conditions. The purpose of this paper is to investigate the effect of CAP and TAP on the ultrastructure of the erythroblasts in mouse splenic colonies. MATERIALS AND METHODSC57BL mice, 8 to 12-week-old, were used in the present experiments.Lethally irradiated mice were injected with 1 x 105 normal bone marrow cells taken from mice of the same strain according to the original method by Till and McCulloch (1961).

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Section: Discussionsupporting

confidence: 67%