2019
DOI: 10.1021/acs.analchem.9b04537
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Anodic Electrochemiluminescence of Carbon Dots Promoted by Nitrogen Doping and Application to Rapid Cancer Cell Detection

Abstract: In this work, a kind of novel nitrogen doped hydrazide conjugated carbon dots (NHCDs) with strong anodic electrochemiluminescence (ECL) at a low excitation potential were synthesized via a one-step solvothermal approach and applied to construct biosensor for rapid cancer cell detection. The nitrogen doping induced a shift of the highest occupied molecular orbital (HOMO) to the upper energy level thus lowered the anodic ECL excitation potential of carbon dots. Especially, comparing to nondoped hydrazide conjuga… Show more

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Cited by 102 publications
(55 citation statements)
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“…An attractive light emitting material for use in LECs is carbon quantum dots (CQDs) due to efficient visible light emissions with tunable band gaps (Yuan et al, 2018 ; Qin et al, 2019 ; Chen et al, 2020a ). First discovered in 2004 (Xu et al, 2004 ), CQDs are small sp 2 and sp 3 containing carbon particles that have been defined as having sizes below 20 nm, low toxicity, strong chemical stability and a resistance to photobleaching (Gan et al, 2016 ; Hu et al, 2019 ; Chen et al, 2020b ).…”
Section: Introductionmentioning
confidence: 99%
“…An attractive light emitting material for use in LECs is carbon quantum dots (CQDs) due to efficient visible light emissions with tunable band gaps (Yuan et al, 2018 ; Qin et al, 2019 ; Chen et al, 2020a ). First discovered in 2004 (Xu et al, 2004 ), CQDs are small sp 2 and sp 3 containing carbon particles that have been defined as having sizes below 20 nm, low toxicity, strong chemical stability and a resistance to photobleaching (Gan et al, 2016 ; Hu et al, 2019 ; Chen et al, 2020b ).…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4][5] Due to their tunable photoluminescence, high stability, and low toxicity,G QDs have numerous applications in aw ide variety of research areas ranging from bioimaging, sensors, energy storage, photovoltaics, to catalysis. [2,[6][7][8][9][10][11][12] GQDs have av ery high surface area to volume ratio, which allows their surfaces to be readily functionalized with variouso rganic or biological species, further increasing their versatility. [13] Heteroatom doping involves the addition of one or more novel elements into the GQD lattice, permitting the tuning of many physical and structural properties.…”
Section: Introductionmentioning
confidence: 99%
“…Graphene quantum dots (GQDs) are a class of zero‐dimensional carbon‐based nanomaterials, characterized by a lateral size of typically 10 nm or less, with a well‐defined crystal lattice [1–5] . Due to their tunable photoluminescence, high stability, and low toxicity, GQDs have numerous applications in a wide variety of research areas ranging from bioimaging, sensors, energy storage, photovoltaics, to catalysis [2, 6–12] . GQDs have a very high surface area to volume ratio, which allows their surfaces to be readily functionalized with various organic or biological species, further increasing their versatility [13] .…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the greater amounts of H 2 O 2 secreted by tumour cells can be used in active metabolism to induce stronger ECL emission from NHCDs combined with Au NPs, which provides another method of cancer monitoring. 143 Nevertheless, without electrode plates, DNA or RNAs as aptamers that can identify HER2 on the surface of MCF-7 cells are applied to amplify the ECL signal through CQDs or synergistic metal-organic frameworks. 144 In addition to FRET and ECL, CQDs can also be utilized to monitor the tumour environment by structural modification, spatial conformation or properties.…”
Section: Applications Of Cqds In Antitumour Diagnosismentioning
confidence: 99%