Anodic Voltammetric determination of gemifloxacin using screen-printed carbon electrode

Radi, Abd-Elgawad; Khafagy, A. H.; El-Shobaky, A.R.; El-mezayen, Hatem A.

doi:10.1016/j.jpha.2012.10.005

Cited by 23 publications

(16 citation statements)

References 23 publications

(21 reference statements)

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“…As suggested by Geremedhin et al [42] and Radi et al [43], this phenomenon may be due to the limited adsorption of RB5 dye at the mercury electrode, which resulted from the saturation of the electrode surface. As shown in Figure 8, the first linear region demonstrated its linearity from 2.…”

Section: The Effect Of Pulse Amplitudementioning

confidence: 88%

Voltammetric Determination of Reactive Black 5 (Rb5) in Waste Water Samples From the Batik Industry

Yaacob¹

2016

MJAS

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A cyclic voltammetry (CV) and differential pulse cathodic stripping voltammetry (DPCSV) studies of RB5 in Britton-Robinson buffer (BRB) at a hanging mercury dropping electrode (HMDE) are described. CV was carried out by cathodic and anodic potential scan over the range of +200 mV to -800 mV with no accumulation time and three well-defined pH-dependent cathodic peaks were observed. The effects of different scan rates, pH of BRB, repetitive cycle and increasing concentrations on the peak height and peak potential of the analyte were studied. The results showed that RB5 dye was adsorbed and irreversibly reduced at the mercury electrode, mainly under diffusion controlled in the optimum pH 4.0 of BRB. By using DPCSV, pH of BRB and various instrumental parameters such as scan rate, accumulation time, accumulation potential and pulse amplitude that may affect the peak height of RB5 were investigated and optimized for RB5 determination. Under the optimized parameters, the peak height was found to be linear with RB5 concentration in the range from 2.5 x 10 -7 mol L -1 to 2.0 x 10 -6 mol L -1 . A detection limit (3SD/m) of 1.3 x 10 -8 mol L -1 was achieved. The precision of the developed method in terms of RSD was 0.55% for intra-day measurement and 0.55%, 0.24% and 0.40%, for inter-day measurements, respectively. The developed method was successfully applied in the determination of RB5 in batik wastewaters with the mean recovery of 83.97 ± 4.78% to 97.93 ± 5.45% (0.5 x 10 -6 mol L -1 ), 95.91 ± 2.68% to 103.49 ± 1.32% (1.0 x 10 -6 mol L -1 ) and 99.17 ± 0.75% to 105.12 ± 0.28% (2.0 x 10 -6 mol L -1 ). The developed method is considered sensitive, precise, accurate, rugged, robust, fast and low cost for routine analysis of RB5 dye in batik wastewaters over the UV-VIS spectrometry method.Keywords: Reactive Black 5, differential pulse cathodic stripping, Britton-Robinson buffer, hanging mercury dropping electrode, batik wastewater samples Abstrak Kajian voltammetri berkitar (CV) dan voltammetri perlucutan denyut kebezaan (DPCSV) terhadap pewarna RB5 dalam larutan penimbal Britton-Robinson (BRB) menggunakan elektrod jatuhan raksa tergantung (HMDE) dihuraikan. CV dijalankan dengan mengimbas potential kathodik dan anodik dari +200 mV ke -800 mV tanpa masa pengumpulan dan tiga puncak diperhatikan selepas imbasan. Kesan perbezaan kadar imbasan, pH BRB, imbasan berkitar yang berulang dan peningkatan kepekatan RB5 ke atas ketinggian dan nilai keupayaan puncak dikaji. RB5 yang dijerap dan diturunkan secara tidak berbalik pada permukaan elektrod merkuri adalah dibawah kawalan difusi pada pH BRB yang optimum iaitu 4.0. Dengan menggunakan DPCSV, pH BRB dan parameter-parameter peralatan yang memberi kesan kepada ketinggian puncak seperti kadar imbasan, masa pengumpulan, keupayaan pengumpulan dan amplitud denyut telah dioptimumkan untuk analisis RB5. Ketinggian puncak berkadar terus dengan kepekatan RB5 dalam julat dari 2.5 x 10 -7 mol L -1 hingga 2.0 x 10 -6 mol L -1 . Had pengesanan adalah 1.3 x 10 -8 mol L -1 . Ketepatan (RSD...

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Section: The Effect Of Pulse Amplitudementioning

confidence: 88%

Voltammetric Determination of Reactive Black 5 (Rb5) in Waste Water Samples From the Batik Industry

Yaacob¹

2016

MJAS

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“…In the last years, electrochemical methods have drawn attention [28][29][30][31], due to their high sensitivity and accuracy, which make them convenient for the qualitative and quantitative analysis of organic compounds contained in pharmaceuticals [32][33][34][35][36]. They are characterized by simple measurements and short times of sample analysis in low cost apparatus, in comparison to chromatographic methods [37][38][39][40]. The most common electrochemical methods include differential pulse (DPV) and cyclic (CV) voltammetry [41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical and Spectrophotometric Determination of N-acetyl-p-aminophenol in Pharmaceuticals

Goclik¹,

Chrześcijańska²,

Kuśmierek³

et al. 2019

Port. Electrochim. Acta

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Electrochemical oxidation of N-acetyl-p-aminophenol (AAP) and selected pharmaceutical products containing AAP is described in this study. Investigations were carried out at Pt electrode, with the application of cyclic (CV) and differential pulse (DPV) voltammetry. AAP was irreversibly oxidized in, at least, one electrode step, with potentials lower than the potential at which oxygen evolution started. Electrochemical methods based on voltammetric techniques (DPV and CV) have been developed for AAP determination in commercial pharmaceutical drugs. AAP content in pharmaceuticals was determined on the base of dependences of current intensity (electroanalytical measurements) and absorbance (UV-VIS spectra). The obtained results using both methods were in good agreement. The validation of CV, DPV and spectrophotometric methods is also presented. Spectrophotometric and voltammetric responses linearly increased with increasing AAP concentrations, in the range from 0.2 to 5 mmol L-1 , with a correlation coefficient of 0.997 (UV-VIS), 0.999 (CV) and 0.998 (DPV). Both electrochemical methods are simple, reliable and sufficiently accurate and precise for AAP quantification in commercial drug samples (tablets). The analysis took only 5 minutes of manual operation, including Pt electrode pre-treatment.

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“…Screen-printed electrodes (SPEs), are low cost disposable sensors with a three-electrode configuration (Working, Reference and Counter electrodes), providing in this way a miniaturized electrochemical cell. In literature, their capability on investigating drug formulations with their corresponding metabolites is limited (Radi et al, 2013;Kauffmann et al, 2011). Thus, further studies with different types of phase I reactions and multiple pathways are required to prove the efficient use of SPE in metabolism.…”

Section: Introductionmentioning

confidence: 99%

Electrochemistry of Eugenol and its Metabolism on a Bare Screen-Printed Electrode

Vasiliadou¹

2018

AJS

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Eugenol is an essential oil widely used in pharmaceutical and food industry. However, the metabolism of eugenol leads to the formation of a highly reactive phenoxyl radical that can induce toxicity with macromolecules. Herein, a simple and a costeffective methodology was described for the mimicry of eugenol metabolism. Electrochemical measurements were recorded on bare screen-printed electrodes (SPEs) and the generated metabolites were collected and detected by electrospray ionization (ESI)/Mass spectrometry (MS). The reactive intermediate was successfully formed illustrating a cheaper alternative towards the mimicry of human metabolism.

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Anodic Voltammetric determination of gemifloxacin using screen-printed carbon electrode

Cited by 23 publications

References 23 publications

Voltammetric Determination of Reactive Black 5 (Rb5) in Waste Water Samples From the Batik Industry

Voltammetric Determination of Reactive Black 5 (Rb5) in Waste Water Samples From the Batik Industry

Electroanalytical and Spectrophotometric Determination of N-acetyl-p-aminophenol in Pharmaceuticals

Electrochemistry of Eugenol and its Metabolism on a Bare Screen-Printed Electrode

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