This article provides an overview, primarily from an experimental perspective, of recent progress and future prospects in using helium to realize a range of quantum materials of generic interest, by "top-down" and "bottom-up" nanotechnology. We can grow model systems to realise new quantum states of matter, and explore key issues in condensed matter physics. In the language of cold atomic gases, two dimensional and confined 3 He and 4 He provide "quantum simulators", with the potential to uncover new emergent quantum states. These include: strictly 2D Fermi system with Mott-Hubbard transition; interacting coupled 2D fermion-boson system; heavy fermion quantum criticality; ideal 2D frustrated ferromagnetism; 2D quantum spin liquid; intertwined superfluid and density wave order with emergent large symmetry; topological mesoscopic superfluidity (new materials and emergent excitations).