An intelligent evaluation method of power information intrusion tolerance based on machine learning is proposed to solve the problems of selection of evaluation indexes, poor evaluation accuracy and efficiency in the evaluation method of power information intrusion tolerance. An intelligent evaluation system of power information intrusion tolerance is established, and an intelligent evaluation model is established by using random forest algorithm. The random forest algorithm determines the evaluation weight according to the quantitative value of the index, sets the value of the intrusion risk function, and obtains the intelligent evaluation results of intrusion tolerance. The method studied is applied to the comparative evaluation experiment of the survivability situation of the power information physical system. The evaluation mean square deviation of the intelligent evaluation method based on machine learning is less than 0.1, the average time is 140.72ms, and the evaluation efficiency is increased by 42.51%. At 1000min, the reliability value is still 0.46, which has practical significance.