Anomaly of cervical vertebrae found on orthodontic examination: 8-year-old boy with cleft lip and palate diagnosed with Klippel-Feil syndrome

Yoshihara, Toshihiro; Suzuki, Jun-Ichi; Yawaka, Yasutaka

doi:10.2319/110409-620.1

Cited by 5 publications

(9 citation statements)

References 9 publications

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“…Klippel-Feil anomaly occurs in 1/40,000-42,000 live births ( Yoshihara, Suzuki, & Yawaka, 2010 ). The condition was initially described by Maurice Klippel and Andre Feil in 1912 and characterized by congenital fusion of at least two of seven cervical vertebrae, with limitations to the movement of the head or neck, a short neck, and a low posterior hairline ( Yoshihara et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

“…Helmi and Pruzansky (1980) cite up to 17% of these cases to be associated with cleft palate. Yoshihara et al (2010) compared cleft lip/cleft palate (CL/CP) and control patients with patients with vertebral fusion. Yoshihara et al (2010) compared cleft lip/cleft palate (CL/CP) and control patients with patients with vertebral fusion.…”

Section: Discussionmentioning

confidence: 99%

“…The authors suggest that close attention from the craniofacial providers, including the geneticist, is crucial to these conditions being diagnosed ( Yoshihara et al, 2010 ). This study proposed that larger sample sized studies were needed to more clearly study the severity of CL/CP as it relates to vertebral anomalies.…”

Section: Pediatric Departmentmentioning

confidence: 99%

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An Uncommon Case

Langevin

Mabry

Castiglione

2014

Plastic Surgical Nursing

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refl ux (home on ranitidine), periodic oxygen desaturations attributed to choanal stenosis (diagnosed on CT scan and MR image) discharged on nasal steroid and oxygen saturation monitor, cleft palate, and feeding concerns had improved (discharged with a Haberman bottle and instructions), elevated cystic fi brosis screen (IRT 188 with planned sweat test). Months and 7 MonthsSee Figures 4a and 4b and 5a and 5b . Normal examination with the exception of a soft palate cleft, left torticollis, and right-sided occipital plagiocephaly. The left side of the face was noted to be slightly smaller than the right. Sweat test was reported as negative. Year 1Months(Failed 3 palate repair attempts due to respiratory insuffi ciency, history of otitis media, and pneumonia.) The examination noted the soft cleft palate, left torticollis, and defi cient left jaw and head tilt and was otherwise normal. FIGURE 2 CT cervical spine without contrast. FIGURE 3 MRI of the cervical, thoracic and lumbosacral spine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An Uncommon Case

Langevin

Mabry

Castiglione

2014

Plastic Surgical Nursing

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“…[26] One of those syndromes is Klippel-Feil syndrome. [27] It is characterized by congenital fusion of at least two of seven cervical vertebrae in the cervical spine, with limitations to movement of the head or neck, a short neck, and a low posterior hairline in patients with CL and palate.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Association of Cleft Lip and Cleft Palate With Cervical Vertebral Anomalies: A Lateral Cephalograph Study

Jha

Kumar

et al. 2019

IJMBS

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The precise origin of cervical vertebral anomalies is still unstated, but it has been suggested that the association between abnormal development of cervical vertebrae and the maxilla and the mandible might be caused by a developmental fault of the mesenchyme as these structures might be dependent on the similar para-axial mesoderm. Hence it is appropriate to focus on this area of research and to consider the craniofacial morphology as an important diagnostic tool in Orthodontic treatment planning. The present study was planned to evaluate the association of Cleft lip and Cleft palate with cervical vertebral anomalies. The present study was planned in Department of Pediatric and Preventive Dentistry, Buddha Institute of Dental Sciences & Hospital, Patna, Bihar, India. Thirty cases of Cleft Lip and Cleft Palate (CLCP) patients were enrolled in the present study. The age of the patients ranged from 5 years to 15 years. The cleft sample were subdivided into patients with CP only, and unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP). Radiographs were examined on a film viewer by a single examiner. The profile of first four cervical vertebrae and Atlanto Occipital Articulation were structurally traced on an acetate paper with 3H lead pencil under optimum illumination and Cervical Vertebral Anomalies (CVA) were registered and categorized into Posterior Arch Deficiencies - PAD (dehiscence and spina bifid) and fusion. The present study concludes the association between cleft lip and palate and Cervical Vertebral Anomalies indicating that CVA may be implicated as the etiology of cleft lip and palate. The present study showed a specific relation between the Cleft Palate and cervical anomalies and the vertebral anomalies following a specific pattern in different types of cleft was found to be PAD which occurred more frequently in UCLP and CP only and fusion occurring significantly more often in BCLP. Keywords: Cleft Lip and Cleft Palate; Cervical Vertebral Anomalies; Dehiscence; Fusion; Lateral Cephalograph

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“…Cervical vertebral anomalies can present with myelopathy, cause limitation in neck movement, muscular atrophy, and regional sensory loss. 2 Early diagnosis of cervical vertebrae anomalies (CVA) is critical in determining the risk of associated diseases at the time of presentation in young patients and the occurrence of secondary neurological symptoms later in life.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of cervical vertebrae anomalies in patients with cleft lip and palate

Kharbanda

Qureshi

Kandasamy

2019

Australasian Orthodontic Journal

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To investigate the prevalence of cervical vertebral anomalies (CVA) in a group of patients presenting with cleft lip and palate (CLP) and to compare with a non-cleft population. Material and methods: The sample comprised of 150 lateral cephalograms of non-syndromic patients with CLP and 150 noncleft age-matched controls. The age range of both groups covered 6 to 20 years. An expert radiologist blinded to the cleft status evaluated the cephalograms for CVA and categorised them into normal, fusion, dehiscence and multiple cervical anomalies. The cleft group was subdivided according to the types of cleft (UCLP/ BCLP/ CPO) and gender (male/female). The CVA prevalence was compared between the cleft and non-cleft patients. Results: The prevalence of CVA was 37.7% and 20.7% in cleft and non-cleft patients, respectively. The difference was statistically significant with a p-value <0.01. Of the types of clefts, a left UCLP had the highest prevalence of CVA (47.2%), with fusion (35.8%) most commonly seen. On comparing CLP with CPO, no significant variation was observed between the types of anomalies. Conclusions: A high prevalence of CVA was observed in cleft patients compared with non-cleft subjects. The prevalence of CVA was similar between males and females. The practitioner should carefully evaluate the lateral cephalogram of CLP patients for CVA, which otherwise may remain undetected and lead to neurological symptoms later in life.

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Anomaly of cervical vertebrae found on orthodontic examination: 8-year-old boy with cleft lip and palate diagnosed with Klippel-Feil syndrome

Cited by 5 publications

References 9 publications

An Uncommon Case

An Uncommon Case

Evaluation of Association of Cleft Lip and Cleft Palate With Cervical Vertebral Anomalies: A Lateral Cephalograph Study

Prevalence of cervical vertebrae anomalies in patients with cleft lip and palate

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