Anorexie mentale de l’adolescent : conséquences sur la minéralisation osseuse

Nicaise, D.; Beaumesnil, M.; Chaillou, E.; Wagner, Adriana; Avarello, Guillaume; Audran, Maurice; Giniès, J.-L.

doi:10.1016/j.arcped.2011.10.022

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…In fact, malnutrition during the pubertal growth spurt leads to stunted growth, which may not be caught up afterwards [5]. The major consequence is bone demineralization, which has multifactorial pathophysiologic causes (malnutrition, excessive exercise, hypo-estrogenism, hypogonadism with primary and secondary amenorrhoea) [6,7]. Most of the time, anorexia occurs during adolescence around the menarche, between age 11 to 14 years for most girls.…”

Section: Introductionmentioning

confidence: 99%

Earlier diagnosis in anorexia nervosa: better watch growth charts!

et al. 2020

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Background: A better understanding of the healthcare pathway of children and adolescents with anorexia nervosa (AN) may contribute to earlier detection and better disease management. Here we measured and compared the symptomatic time to diagnosis (TTD) (time between the first symptoms, as reported by parents, and the diagnosis) and the auxological TTD (time between the deviation in the weight growth curve and the diagnosis). Methods: We performed a monocentric retrospective study including all patients age 9 years to 16 years who were hospitalized in Nantes University Hospital for AN between 2013 and 2016. We analysed the two TTDs by medical record review and growth curve investigation. TTDs were described by medians and Kaplan-Meier curves. Two profiles of patients were compared according to the kinetics of growth deviation and the occurrence of symptoms. Results: Among the 137 patients included, the median symptomatic and auxological TTDs was 7.0 months (IQR: 4.0-12.0) and 7.2 months (IQR: 2.0-18.0). TTDs were significantly different but clinically similar. For 48% of the patients, a deviation in the growth curve could have been noted at a median of 9.7 months (IQR: 3.0-18.0) before the first symptoms were reported by parents. Those patients showed significantly slower weight loss than did patients with first symptoms reported before growth deviation (weight loss rate 0.41% vs 1.90% per month, p < 0.0001). Conclusions: Careful study of growth curves remains an essential step in detecting eating disorders, possibly allowing for earlier detection of the disease in nearly half of these patients.

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Section: Introductionmentioning

confidence: 99%

Earlier diagnosis in anorexia nervosa: better watch growth charts!

et al. 2020

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“…On average, participants were older and more severe compared with previous studies on this subject. 8,[24][25][26] The prevalence of low BMD at lumbar spine was 51% with an average Z-score of −2.2 SD. Pre-existing research reports lower prevalence rates, ranging from 21% to 40% depending on population age and diagnostic criteria (T-scores vs Z-scores).…”

Section: Discussionmentioning

confidence: 99%

Bone mineral density at extremely low weight in patients with anorexia nervosa

Bemer

Lodovico

Haykanush

et al. 2021

Clinical Endocrinology

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Anorexia nervosa (AN) is a severe eating disorder characterized by an emotional and cognitive inability to maintain a normal weight.Quantitative and qualitative restriction of nutritional intakes, purging behaviours, physical hyperactivity and laxative abuse are the main strategies to control weight and shape. These behaviours are maintained by a persisting distortion of body image, generating a vicious circle of weight loss. 1 Prevalence varies between 0.9% and 4% among women and is 10 to 13 times lower among men. [2][3][4] Weight control strategies progressively lead to malnutrition, which in turn can generate acute and chronic somatic complications, functional damage and decreased quality of life. 5 Bone mineral density (BMD) loss is a potentially irreversible consequence of AN,6,7 favoured by the combined effect on malnutrition, vitamin D deficiency, hypoestrogenism, elevated serum cortisol and low body mass index (BMI). 7,8 Epidemiological studies indicate that 45 to 95% of patients with AN suffer from osteopenia and up to 40% suffer from osteoporosis. 9-11 Bone fragility exposes these patients to a sevenfold increased risk of fractures, compared to healthy individuals of

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