Another association between the properdin system (BF) and insulin‐dependent diabetes in south India

Family histories of 135 Asian Indian and 146 European NIDD patients attending clinics in Ealing and Hammersmith Hospitals were obtained, using a detailed questionnaire. Forty‐five per‐cent of Asian and 36% of European patients had a first‐degree relative with diabetes. Twenty‐eight per‐cent of Asians and 20% of Europeans had one diabetic parent. In 10% of Asians and 1% of Europeans, both parents were diabetic (p<0.01). Autosomal‐dominant inheritance was seen in 14% of Asians and 4% of Europeans (p<0.01). The higher frequency of diabetes in parents, and the higher frequency of dominantly‐inherited diabetes among Asians compared to European NIDD patients, suggest that genetic mechanisms operating in NIDD are different in different ethnic groups.

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Family histories in Asian and European non‐insulin‐dependent diabetic patients

Mohan

Sharp

Aber

et al. 1986

Pract Diab Int

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High prevalence of Type 2 (non-insulin-dependent) diabetes among the offspring of conjugal Type 2 diabetic parents in India

et al. 1985

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Summary. The prevalence of Type 2 (non-insulin-dependent) diabetes among offspring of conjugal Type 2 diabetic parents in India was determined by performing oral glucose tolerance tests. Diabetes was present in 50% of offspring, and 12% had impaired glucose tolerance according to the National Diabetes Data Group criteria. Thus, 62% of all offspring had abnormal glucose tolerance tests. This is the highest prevalence rate for diabetes among offspring of conjugal diabetic parents and might represent an ethnic variation of the genetic factors operating in Indian patients with Type 2 (non-insulin-dependent) diabetes.

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Genetic polymorphism of properdin factor B (BF) in Chinese patients with two types of diabetes mellitus

Luo

et al. 1986

Jap J Human Genet

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SummaryThe distribution of phenotypes for properdin factor B (BF) has been investigated in 50 IDDM patients and 52 NIDDM patients living in Guangzhou, southern China, using high voltage agarose gel electrophoresis followed by immunofixation. A significant decrease in the frequency of BF F positive patients (p<0.01) and an increase in the gene frequency of BF*S (p<0.005) were found in IDDM as compared to 259 normal controls. The relative risk for the BF F positive patients in IDDM was 0.15. On the other hand, no significant association was observed between BF types and NIDDM.

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Another association between the properdin system (BF) and insulin‐dependent diabetes in south India

Cited by 6 publications

References 2 publications

Family histories in Asian and European non‐insulin‐dependent diabetic patients

Family histories in Asian and European non‐insulin‐dependent diabetic patients

High prevalence of Type 2 (non-insulin-dependent) diabetes among the offspring of conjugal Type 2 diabetic parents in India

Genetic polymorphism of properdin factor B (BF) in Chinese patients with two types of diabetes mellitus

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