Another case of generalized bullous fixed drug eruption following an adenoviral vector‐based COVID‐19 vaccine (ChAdOx1 nCov‐19)

Generalized fixed drug eruption following Pfizer‐BioNtech COVID‐19 vaccination

“…Notably, polysorbate 80, the vaccine excipient, does not seem to be the culprit allergen. 4,7 FDE following COVID-19 vaccination appears to have a very low incidence rate, and its outcome is generally favorable. However, our case illustrates the potential for prolonged cosmetic sequelae following FDE secondary to the Pfizer-BioNTech COVID-19 vaccination.…”

“…Similarly, a reaction to ChAdOx1 nCoV‐19 virotopes in adenoviral vectored vaccines 4 has been proposed as a possible mechanism. Notably, polysorbate 80, the vaccine excipient, does not seem to be the culprit allergen 4,7 …”

“…To date, only five cases of FDE following COVID‐19 vaccination have been reported, 3 following mRNA and 2 after adenoviral vector‐based vaccines (Table 1). 4–8 Here, we report a patient with generalized non‐bullous FDE following vaccination with the mRNA‐based Pfizer‐BioNTech COVID‐19 vaccine.…”

Generalized Fixed Drug Eruption Following Pfizer-BioNtech COVID-19 Vaccination

“…To date, only five cases of FDE following COVID-19 vaccination have been reported, 3 following mRNA and 2 after adenoviral vector-based vaccines (Table 1 ) [4][5][6][7][8]. Here, we report a patient with generalized non-bullous fixed drug eruption following vaccination with the mRNA-based Pfizer-BioNTech COVID-19 vaccine.…”

“…Similarly, a reaction to ChAdOx1 nCoV-19 virotopes in adenoviral vectored vaccines [4] has been proposed as a possible mechanism. Notably, polysorbate 80, the vaccine excipient, does not seem to be the culprit allergen [4,7]. FDE following COVID 19 vaccination appears to have a very low incidence rate, and its outcome is generally favorable.…”