Antagonic-stress superiority versus meclofenoxate in gerontopsychiatry (alzheimer type dementia)

Popa, Rodica; Schneider, F; Mihalas, George I.; Stefaniga, P.; I, Mihalaş; Mâties, Rosana; Mateescu, Rodica

doi:10.1016/s0167-4943(05)80065-2

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…In August rats, activity of the stress-limiting system that decreases the stress response and attenuates stress-induced changes is higher than in Wistar rats [7,4]. Since emotional stress plays an important role in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) [12,13,14], we hypothesized that genetically determined increase in organism's resistance to stress can counteract the development of this disorder. Published data show that the incidence of acute myocardial infarction in August rats is lower than in Wistar rats [2].…”

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confidence: 99%

Resistance to Neurodegenerative Brain Damage in August and Wistar Rats

et al. 2005

Bull Exp Biol Med

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In Wistar and August rats characterized by different resistance to acute emotional stress we compared the resistance to neurodegenerative brain damage (model of Alzheimers disease) produced by administration of a neurotoxic peptide fragment (25-35) beta-amyloid into the brain. August rats were more resistant to acute stress and development of neurodegenerative disorders compared to Wistar rats. This conclusion was derived from studying animal behavior in conditioned passive avoidance task and open-field test that characterize cognitive function of the brain. Administration of beta-amyloid modulated the behavior of Wistar rats, which reflected the impairment of memory and orientation and exploratory activity in these animals. These disturbances in Wistar rats were accompanied by activation of lipid peroxidation in the hippocampus.

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Resistance to Neurodegenerative Brain Damage in August and Wistar Rats

et al. 2005

Bull Exp Biol Med

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“…The etiopathogenic and synergistic (vs. monotherapy) interventions on Antagonic‐Stress® in (brain) aging processes were demonstrated in (1) preclinical patterns, multiple corrections of hypoanabolism, hypercatabolism, oxidative stress, accompanied with lipofuscinolysis and brain aging pigment diminution; and also in (2) clinical psychogeriatrics, nootropic (anti‐impairment), psychotonic (antifatigue, energoactive), antidepressant, psychostabilizer, anxiolytic, adaptative (antistress) actions. 1‐4 The biological (orthomolecular) nature of its substances, synergism of multiple composition and actions, etiopathogenic, and polyinterventions in the aging process explain the multiple and positive results of Antagonic‐Stress® in brain senescence, and also the efficacy and superiority of this multivalent drug versus monotherapy for the aging phenomena.…”

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confidence: 99%

Synergistic Multitherapy as a Rational Strategy in Aging: Multifactorial Process

Riga

1998

Annals of the New York Academy of Sciences

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“…Seventeen randomised control studies (RCT) were identified 11–27 . Although all are identified as originating from Romania, 11 are multi‐centre and describe how the trial was undertaken in several sites one of which was within Romania.…”

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confidence: 99%