Antagonism of Bradykinin Bronchoconstriction by Anti-Inflammatory Drugs

Piper, Priscilla J.; Vane, John R.

doi:10.1007/978-3-642-66891-3_6

Cited by 3 publications

(1 citation statement)

References 72 publications

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“…In addition to the inhibition of the cyclooxygenase system, aspirin and aspirin-like drugs will inhibit a variety of other enzymes (Smith & Dawkins, 1971; Paulus & Whitehouse, 1973;Piper & Vane, 1979;Vargaftig, 1978;Morley, 1978). However, the evidence indicates that many of the effects of this class of drugs on platelet function can be explained by their ability to block prostaglandin synthesis and thus block the second phase of platelet aggregation observed in the in vitro system (Smith & Willis, 1971).…”

Section: Introductionmentioning

confidence: 99%

Potential therapeutic applications of aspirin and other cyclo‐oxygenase inhibitors.

Ae¹,

Rosenberg²

1980

Brit J Clinical Pharma

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1 The ubiquitous actions of the cyclo‐oxygenase inhibitors are described. 2 These include the inhibitory effect on prostaglandin synthesis and the direct effect of aspirin on lymphocytes and their ability to produce lymphokines. 3 Aspirin reduces some types of platelet aggregation possibly involving inhibition of the precursors of thromboxane A2 and prostacyclin. 4 The therapeutic implications in relation to transient ischaemic attacks, coronary artery disease and reno‐allograft rejection are discussed. 5 The beneficial and adverse effects on the gastro‐intestinal tract are described. 6 The effects of aspirin‐like drugs on the genito‐urinary tract are described with particular reference to their adverse effects on labour and their therapeutic effect on dysmenorrhoea.

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