Influence of bronchial C fibre receptors on respiration in cats: possible role in humans

Anand, Ashima

doi:10.1016/s0034-5687(00)00137-7

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…2). 18,19 We cannot determine from the present data if apnea expression during NREM sleep may have been a specific effect of C-fiber activation on respiratory pattern generation per se, or if it may have resulted indirectly from an overall reduction in respiratory drive. 2).…”

Section: Discussionmentioning

confidence: 79%

C-Fiber Activation Exacerbates Sleep-Disordered Breathing in Rats

et al. 2004

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We reported previously that activation of vagal feedback by protoveratrines or serotonin exacerbates sleep apnea in rats, but each of these agents activates multiple afferent fiber types. To elucidate the specific impact of C-fiber activity on sleep apnea, the present study utilized capsaicin (CAP), which stimulates C-fibers via the CAP receptor. Nine adult Sprague-Dawley rats were instrumented for chronic polysomnography and recorded for 6 hours on four occasions. Prior to each recording, the animals received an intraperitoneal injection of either saline (control), or CAP 0.1, 1.0, or 10.0 mg/kg. Respiration was monitored by single-chamber plethysmography and apneas were scored as breaths longer than 2.5 seconds not preceded by a sigh. CAP increased apneas during non-rapid eye movement (NREM) sleep (p < 0.05 vs control) and reduced respiratory minute ventilation by about 15% in all behavioral states (waking, NREM, and REM sleep). We conclude that selective pharmacological activation of C-fibers produces a diathesis of sleep-disordered breathing specific to NREM sleep in rats.

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Section: Discussionmentioning

confidence: 79%

C-Fiber Activation Exacerbates Sleep-Disordered Breathing in Rats

et al. 2004

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“…Of note, a greater diastolic impairment was found to be predictive of daytime CA in our study at least in HFrEF patients. Increased ventricular stiffening and impaired relaxation, together with increased LV and LA pressure, might in fact be responsible of chemoreflex activation via pulmonary J-receptor or C-fibers stimulation (31–33), thus promoting ventilatory instability, as already demonstrated in a canine model of LA pressure augmentation via balloon inflation (34).…”

Section: Discussionmentioning

confidence: 96%

Central and Obstructive Apneas in Heart Failure With Reduced, Mid-Range and Preserved Ejection Fraction

Borrelli

Gentile

Sciarrone

et al. 2019

Front. Cardiovasc. Med.

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Background: Although central apneas (CA) and obstructive apneas (OA) are highly prevalent in heart failure (HF), a comparison of apnea prevalence, predictors and clinical correlates in the whole HF spectrum, including HF with reduced ejection fraction (HFrEF), mid-range EF (HFmrEF) and preserved EF (HFpEF) has never been carried out so far.Materials and methods: 700 HF patients were prospectively enrolled and then divided according to left ventricular EF (408 HFrEF, 117 HFmrEF, 175 HFpEF). All patients underwent a thorough evaluation including: 2D echocardiography; 24-h Holter-ECG monitoring; cardiopulmonary exercise testing; neuro-hormonal assessment and 24-h cardiorespiratory monitoring.Results: In the whole population, prevalence of normal breathing (NB), CA and OA at daytime was 40, 51, and 9%, respectively, while at nighttime 15, 55, and 30%, respectively. When stratified according to left ventricular EF, CA prevalence decreased (daytime: 57 vs. 43 vs. 42%, p = 0.001; nighttime: 66 vs. 48 vs. 34%, p < 0.0001) from HFrEF to HFmrEF and HFpEF, while OA prevalence increased (daytime: 5 vs. 8 vs. 18%, p < 0.0001; nighttime 20 vs. 29 vs. 53%, p < 0.0001).In HFrEF, male gender and body mass index (BMI) were independent predictors of both CA and OA at nighttime, while age, New York Heart Association functional class and diastolic dysfunction of daytime CA. In HFmrEF and HFpEF male gender and systolic pulmonary artery pressure were independent predictors of CA at daytime, while hypertension predicted nighttime OA in HFpEF patients; no predictor of nighttime CA was identified. When compared to patients with NB, those with CA had higher neuro-hormonal activation in all HF subgroups. Moreover, in the HFrEF subgroup, patients with CA were older, more comorbid and with greater hemodynamic impairment while, in the HFmrEF and HFpEF subgroups, they had higher left atrial volumes and more severe diastolic dysfunction, respectively. When compared to patients with NB, those with OA were older and more comorbid independently from background EF.Conclusions: Across the whole spectrum of HF, CA prevalence increases and OA decreases as left ventricular systolic dysfunction progresses. Different predictors and specific clinical characteristics might help to identify patients at risk of developing CA or OA in different HF phenotypes.

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“…1992). In a study elsewhere, capsaicin produced apnoea followed by rapid shallow breathing and hypotension in anaesthetized cats similar to PBG (Anand 2000). Thus the hypotensive and bradycardiac responses are consistently seen with PBG (at all concentrations) or capsaicin.…”

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confidence: 92%