Antagonism of quinpirole by (+)-AJ 76: possible involvement of D3 receptors

The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produced variable results on rate of cocaine intake on an FR1 schedule, indicating that rate may on occasion be insensitive to changes in cocaine reinforcement. In animals previously trained to self-administer cocaine, (-)-DS 121 failed to maintain responding when substituted for cocaine. This profile suggests that (-)-DS 121 is a promising new candidate for the treatment of cocaine abuse.

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Effect of (−)-DS 121 and (+)-UH 232 on cocaine self-administration in rats

Smith

Piercey

Roberts

1995

Psychopharmacology

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Mesencephalic microinjections of neurotensin-(1–13) and its C-terminal fragment, neurotensin-(8–13), potentiate brain stimulation reward

Rompré¹,

Gratton²

1993

Brain Research

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The putative dopamine D3 agonist, 7-OH-DPAT, reduces dopamine release in the nucleus accumbens and electrical self-stimulation to the ventral tegmentum

1995

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Antagonism of quinpirole by (+)-AJ 76: possible involvement of D3 receptors

Cited by 7 publications

References 5 publications

Effect of (−)-DS 121 and (+)-UH 232 on cocaine self-administration in rats

Effect of (−)-DS 121 and (+)-UH 232 on cocaine self-administration in rats

Mesencephalic microinjections of neurotensin-(1–13) and its C-terminal fragment, neurotensin-(8–13), potentiate brain stimulation reward

The putative dopamine D3 agonist, 7-OH-DPAT, reduces dopamine release in the nucleus accumbens and electrical self-stimulation to the ventral tegmentum

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