Antagonistic effects of 24R,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 on L-type Ca2+ channels and Na+/Ca2+ exchange in enterocytes from Atlantic cod (Gadus morhua)

Abstract

There is mounting evidence that vitamin D and its metabolites play important roles in regulating plasma calcium concentrations in teleost fish as in other vertebrates. The aims of the present study were to elucidate the possible cellular target mechanisms for the rapid actions of 24R,25(OH) 2

Functional characterisation and genomic analysis of an epithelial calcium channel (ECaC) from pufferfish, Fugu rubripes

“…It was therefore somewhat surprising to find that the Fugu gut contained a relatively low level of FrECaC transcript. The weak expression of FrECaC in the intestine found in the present study is, however, in accordance with previous pharmacological evidence that an L-type calcium channel mediates patent brush border membrane calcium uptake in enterocytes of Atlantic cod (Larsson et al, 1998(Larsson et al, , 2002. Physiological data on zinc uptake also suggest that ECaC may be more important as an uptake system in the gill than in the intestine.…”

Effects of dietary vitamin D3 administration on innate immune parameters of seabream (Sparus aurata L.)

“…Since fish stand between the invertebrates and vertebrates in evolution they serve as a unique model for the study of the evolutionary and physiological significance of vD 3 . In spite of this, knowledge on the role of vD 3 in fish is poor because comparative physiological studies on marine teleosts are few [11], and the role of vD 3 in Ca regulation in teleosts remains equivocal [27][28][29].…”

Molecular characterization of an epithelial Ca2+ channel-like gene from crayfishProcambarus clarkii

“…Expression of the ECaC transcript in pufferfish intestine was low, confirming that, as in crayfish, the intestine of teleost fish is less important than the gill in Ca 2+ absorption . As in invertebrates, pharmacological evidence has suggested that other types of Ca 2+ channel may mediate brush-border membrane Ca 2+ uptake in fish enterocytes (Larsson et al, 2002).…”