Antagonistic negative and positive neurons of the basolateral amygdala

Kim, Joshua; Pignatelli, Michele; Xu, Sangyu; Itohara, Shigeyoshi; Tonegawa, Susumu

doi:10.1038/nn.4414

Cited by 360 publications

(514 citation statements)

References 44 publications

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“…These results also demonstrate that the BLA consists of multiple zones, which receive unique inputs and make distinct outputs, akin to the different layers found in cerebral cortex. In the future, it will be interesting to examine how these zones map onto genetic cell types in the BLA (Kim et al, 2016; McCullough et al, 2016). It will also be important to compare inputs from more ventral, infralimbic (IL) PFC, which are known to have different functional roles in emotional behavior.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, due to the limited effects on AS neurons, the PFC may have more modest regulation of reward processing (Ambroggi et al, 2008; Beyeler et al, 2016; Namburi et al, 2015; Stuber et al, 2011). However, a genetically defined subgroup of AS neurons are involved in aversive behaviors (Kim et al, 2016), and further studies are needed to determine if the synaptic inputs or intrinsic properties of this subgroup differs from the majority of AS neurons. Moreover, both AS and AH neurons in lateral BLA do not receive PFC input, suggesting they participate in distinct circuits driven by alternative inputs.…”

Section: Discussionmentioning

confidence: 99%

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Prefrontal Cortex Drives Distinct Projection Neurons in the Basolateral Amygdala

2017

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SUMMARY The prefrontal cortex (PFC) regulates emotional behavior via top-down control of the basolateral amygdala (BLA). However, the influence of PFC inputs on the different projection pathways within the BLA remains largely unexplored. Here we combine whole-cell recordings and optogenetics to study these cell-type specific connections in the mouse BLA. We characterize PFC inputs onto three distinct populations of BLA neurons that project to either the PFC, ventral hippocampus or Nucleus Accumbens. We find that PFC-evoked synaptic responses are strongest at amygdala-cortical and amygdala-hippocampal neurons, and much weaker at amygdala-striatal neurons. We assess the mechanisms for this targeting, and conclude that it reflects fewer connections onto amygdala-striatal neurons. Given the similar intrinsic properties of these cells, this connectivity allows the PFC to preferentially activate amygdala-cortical and amygdala-hippocampal neurons. Together, our findings reveal how PFC inputs to the BLA selectively drive feed-back projections to the PFC and feed-forward projections to the hippocampus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prefrontal Cortex Drives Distinct Projection Neurons in the Basolateral Amygdala

2017

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“…The BLA contains two spatially segregated, genetically distinct populations of cortical-like excitatory pyramidal neurons—Protein phosphatase 1 regulatory subunit 1B + ( Ppp1r1b + also known as DARPP-32) parvocellular neurons and R-spondin 2 + ( Rspo2 + ) magnocellular neurons (Carlsen and Heimer, 1988; Hemmings et al, 1984; Kim et al, 2016; McDonald, 1984; Pitkanen et al, 1997; Swanson and Petrovich, 1998). BLA Ppp1r1b + neurons elicit appetitive behaviors, inhibit defensive behaviors, and send projections to the lateral (CeL) and medial (CeM) nucleus of the CeA.…”

Section: Introductionmentioning

confidence: 99%

“…BLA Ppp1r1b + neurons elicit appetitive behaviors, inhibit defensive behaviors, and send projections to the lateral (CeL) and medial (CeM) nucleus of the CeA. BLA Rspo2 + neurons elicit defensive behaviors, inhibit appetitive behaviors, and send projections to the capsular (CeC) nucleus of the CeA (Kim et al, 2016). The CeA consists of GABAergic striatal medium spiny-like neurons, and similar to the BLA, is critical for appetitive and defensive behaviors (Gallagher and Chiba, 1996; McDonald, 1991; Swanson and Petrovich, 1998).…”

Section: Introductionmentioning

confidence: 99%

Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors

Kim

Zhang

Muralidhar

et al. 2017

Neuron

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382

493

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Summary Basolateral amygdala (BLA) principle cells are capable of driving and antagonizing behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which also participates in negative and positive behaviors. However, the CeA has primarily been studied as the site for negative behaviors and the causal role for CeA circuits underlying appetitive behaviors is poorly understood. Here we identified several genetically distinct populations of CeA neurons that mediate appetitive behaviors and dissected the BLA to CeA circuit for appetitive behaviors. Protein phosphatase 1 regulatory subunit 1B+ BLA pyramidal neurons to dopamine receptor 1+ CeA neurons define a pathway for promoting appetitive behaviors, while R-spondin 2+ BLA pyramidal neurons to dopamine receptor 2+ CeA neurons define a pathway for suppressing appetitive behaviors. These data reveal genetically defined neural circuits in the amygdala that promote and suppress appetitive behaviors analogous to the direct and indirect pathway of the basal ganglia.

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“…One population of neurons receive input from the BLA Ppp1r1b+ neuronal cells, which can be characterized by their ability to induce reward-seeking behavior. Another population of neurons within the CeA receive input from the BLA Rspo2+ neurons, which was shown to inhibit appetitive responding (Kim et al 2016). Altogether, the two pathways are suggested to form a BLA-to-CeA circuit for the antagonistic control of reward-related behavior.…”

Section: Stimuli and Data Analysis Implicationsmentioning

confidence: 97%

Functional organization of the human amygdala in appetitive learning

Kolada¹,

Bielski²,

Falkiewicz³

et al. 2017

Acta Neurobiologiae Experimentalis

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The amygdala is a small subcortical structure located bilaterally in medial temporal lobes. It is a key region for emotional processes and some forms of associative learning. In particular, the role of the amygdala in processing of negative emotions and aversive learning has been shown in numerous studies. However, involvement of this structure in processing of positive affect and appetitive learning is not fully understood. Previous experiments in animals are not consistent. While some authors implicate only the centromedial part of the amygdala in appetitive learning, the others suggest contribution of both centromedial and basolateral subregions. Although from the evolutionary perspective appetitive learning is equally important as aversive learning, research on the role of the human amygdala and its subregions in appetitive learning is undertaken relatively rarely and the results are not conclusive. Therefore, the aim of this review is twofold: to summarize the current knowledge in this field and to indicate and discuss the factors, which might affect the observed level of the amygdala activity during appetitive learning in humans.

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Antagonistic negative and positive neurons of the basolateral amygdala

Cited by 360 publications

References 44 publications

Prefrontal Cortex Drives Distinct Projection Neurons in the Basolateral Amygdala

Prefrontal Cortex Drives Distinct Projection Neurons in the Basolateral Amygdala

Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors

Functional organization of the human amygdala in appetitive learning

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